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Benign Kidney Neoplasm

MedGen UID:
96926
•Concept ID:
C0496892
•
Neoplastic Process
Synonyms: Benign Kidney Tumor; Benign neoplasm of kidney; Benign Neoplasm of Kidney; Benign Neoplasm of the Kidney; Benign Renal Neoplasm; Benign renal tumor; Benign Renal Tumor; Benign tumor of kidney; Benign Tumor of Kidney; Benign Tumor of the Kidney; Renal benign neoplasm; Renal Neoplasm, Benign; Renal Tumor, Benign
SNOMED CT: Benign tumor of kidney (92165001); Benign renal tumor (92165001); Renal benign neoplasm (92165001); Benign neoplasm of kidney (92165001)

Definition

A neoplasm that arises from the kidney and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Diagnosis and management of ureteral fibroepithelial polyps in children: a new treatment algorithm.
Li R, Lightfoot M, Alsyouf M, Nicolay L, Baldwin DD, Chamberlin DA
J Pediatr Urol 2015 Feb;11(1):22.e1-6. Epub 2014 Aug 28 doi: 10.1016/j.jpurol.2014.08.004. PMID: 25218353
Incidentalomas: initial management.
Hitzeman N, Cotton E
Am Fam Physician 2014 Dec 1;90(11):784-9. PMID: 25611713

Recent clinical studies

Etiology

Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.
Hes O, Trpkov K
Mod Pathol 2022 Sep;35(9):1140-1150. Epub 2022 Mar 10 doi: 10.1038/s41379-022-01057-z. PMID: 35273336
Bosniak Classification of Cystic Renal Masses, Version 2019: An Update Proposal and Needs Assessment.
Silverman SG, Pedrosa I, Ellis JH, Hindman NM, Schieda N, Smith AD, Remer EM, Shinagare AB, Curci NE, Raman SS, Wells SA, Kaffenberger SD, Wang ZJ, Chandarana H, Davenport MS
Radiology 2019 Aug;292(2):475-488. Epub 2019 Jun 18 doi: 10.1148/radiol.2019182646. PMID: 31210616Free PMC Article
Cystic renal masses.
Hindman NM
Abdom Radiol (NY) 2016 Jun;41(6):1020-34. doi: 10.1007/s00261-016-0761-4. PMID: 27154722
Update on the Diagnosis and Management of Renal Angiomyolipoma.
Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, Perry KT, Nadler RB
J Urol 2016 Apr;195(4 Pt 1):834-46. Epub 2015 Nov 21 doi: 10.1016/j.juro.2015.07.126. PMID: 26612197
Neonatal renal tumours.
Powis M
Early Hum Dev 2010 Oct;86(10):607-12. doi: 10.1016/j.earlhumdev.2010.08.018. PMID: 20888153

Diagnosis

Renal Mass Biopsy.
Quencer KB
Tech Vasc Interv Radiol 2021 Dec;24(4):100774. Epub 2021 Sep 27 doi: 10.1016/j.tvir.2021.100774. PMID: 34895706
WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies.
Warren AY, Harrison D
World J Urol 2018 Dec;36(12):1913-1926. Epub 2018 Aug 19 doi: 10.1007/s00345-018-2447-8. PMID: 30123932Free PMC Article
Imaging of Solid Renal Masses.
Kay FU, Pedrosa I
Urol Clin North Am 2018 Aug;45(3):311-330. Epub 2018 Jun 15 doi: 10.1016/j.ucl.2018.03.013. PMID: 30031457Free PMC Article
Renal leiomyoma.
Mashali N, Awad AT, Trevisan G, El-Bahrawy M
Pathologica 2011 Feb;103(1):22-4. PMID: 21837922
Pediatric renal tumors.
Shamberger RC
Semin Surg Oncol 1999 Mar;16(2):105-20. doi: 10.1002/(sici)1098-2388(199903)16:2<105::aid-ssu4>3.0.co;2-t. PMID: 9988867

Therapy

Role of α- and β-adrenergic signaling in phenotypic targeting: significance in benign and malignant urologic disease.
Archer M, Dogra N, Dovey Z, Ganta T, Jang HS, Khusid JA, Lantz A, Mihalopoulos M, Stockert JA, Zahalka A, Björnebo L, Gaglani S, Noh MR, Kaplan SA, Mehrazin R, Badani KK, Wiklund P, Tsao K, Lundon DJ, Mohamed N, Lucien F, Padanilam B, Gupta M, Tewari AK, Kyprianou N
Cell Commun Signal 2021 Jul 20;19(1):78. doi: 10.1186/s12964-021-00755-6. PMID: 34284799Free PMC Article
Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM
Proc Natl Acad Sci U S A 2021 Jun 15;118(24) doi: 10.1073/pnas.2103240118. PMID: 34099557Free PMC Article
Should Small Renal Masses Be Biopsied?
Leão RR, Ahmad AE, Richard PO
Curr Urol Rep 2017 Jan;18(1):7. doi: 10.1007/s11934-017-0653-3. PMID: 28188595
Active surveillance of small renal masses.
Smaldone MC, Corcoran AT, Uzzo RG
Nat Rev Urol 2013 May;10(5):266-74. Epub 2013 Apr 9 doi: 10.1038/nrurol.2013.62. PMID: 23567498
Tuberous sclerosis complex-associated angiomyolipomas: focus on mTOR inhibition.
Budde K, Gaedeke J
Am J Kidney Dis 2012 Feb;59(2):276-83. Epub 2011 Nov 29 doi: 10.1053/j.ajkd.2011.10.013. PMID: 22130643

Prognosis

Renal Neoplasms in Young Adults.
Gopee-Ramanan P, Chin SS, Lim C, Shanbhogue KP, Schieda N, Krishna S
Radiographics 2022 Mar-Apr;42(2):433-450. doi: 10.1148/rg.210138. PMID: 35230920
Multiparametric MR for Solid Renal Mass Characterization.
Heller MT, Furlan A, Kawashima A
Magn Reson Imaging Clin N Am 2020 Aug;28(3):457-469. Epub 2020 Jun 3 doi: 10.1016/j.mric.2020.03.008. PMID: 32624162
WHO/ISUP classification, grading and pathological staging of renal cell carcinoma: standards and controversies.
Warren AY, Harrison D
World J Urol 2018 Dec;36(12):1913-1926. Epub 2018 Aug 19 doi: 10.1007/s00345-018-2447-8. PMID: 30123932Free PMC Article
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Neonatal oncology.
Bertolone S
Pediatr Clin North Am 1977 Aug;24(3):585-98. doi: 10.1016/s0031-3955(16)33467-8. PMID: 197475

Clinical prediction guides

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.
Zhang Y, Narayanan SP, Mannan R, Raskind G, Wang X, Vats P, Su F, Hosseini N, Cao X, Kumar-Sinha C, Ellison SJ, Giordano TJ, Morgan TM, Pitchiaya S, Alva A, Mehra R, Cieslik M, Dhanasekaran SM, Chinnaiyan AM
Proc Natl Acad Sci U S A 2021 Jun 15;118(24) doi: 10.1073/pnas.2103240118. PMID: 34099557Free PMC Article
Radiomics to better characterize small renal masses.
Kuusk T, Neves JB, Tran M, Bex A
World J Urol 2021 Aug;39(8):2861-2868. Epub 2021 Jan 26 doi: 10.1007/s00345-021-03602-y. PMID: 33495866
Pathomics in urology.
Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725
Acrometastasis: a literature review.
Stomeo D, Tulli A, Ziranu A, Perisano C, De Santis V, Maccauro G
Eur Rev Med Pharmacol Sci 2015 Aug;19(15):2906-15. PMID: 26241547
Active surveillance of small renal masses.
Smaldone MC, Corcoran AT, Uzzo RG
Nat Rev Urol 2013 May;10(5):266-74. Epub 2013 Apr 9 doi: 10.1038/nrurol.2013.62. PMID: 23567498

Recent systematic reviews

Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta-analysis of clinically localized renal masses suspicious for malignancy.
Pierorazio PM, Patel HD, Johnson MH, Sozio SM, Sharma R, Iyoha E, Bass EB, Allaf ME
Cancer 2016 Nov 15;122(21):3267-3276. Epub 2016 Aug 10 doi: 10.1002/cncr.30268. PMID: 27508947
A tumor profile in Edwards syndrome (trisomy 18).
Satgé D, Nishi M, Sirvent N, Vekemans M
Am J Med Genet C Semin Med Genet 2016 Sep;172(3):296-306. Epub 2016 Jul 30 doi: 10.1002/ajmg.c.31511. PMID: 27474103
DWI for Renal Mass Characterization: Systematic Review and Meta-Analysis of Diagnostic Test Performance.
Kang SK, Zhang A, Pandharipande PV, Chandarana H, Braithwaite RS, Littenberg B
AJR Am J Roentgenol 2015 Aug;205(2):317-24. doi: 10.2214/AJR.14.13930. PMID: 26204281
Preoperatively misclassified, surgically removed benign renal masses: a systematic review of surgical series and United States population level burden estimate.
Johnson DC, Vukina J, Smith AB, Meyer AM, Wheeler SB, Kuo TM, Tan HJ, Woods ME, Raynor MC, Wallen EM, Pruthi RS, Nielsen ME
J Urol 2015 Jan;193(1):30-5. Epub 2014 Jul 27 doi: 10.1016/j.juro.2014.07.102. PMID: 25072182
Gender differences in benign renal masses.
Mauermann J, de Martino M, Waldert M, Haitel A, Klingler HC, Remzi M, Klatte T
World J Urol 2013 Oct;31(5):1051-7. Epub 2013 Feb 16 doi: 10.1007/s00345-013-1032-4. PMID: 23417319

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