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Spinal cord tumor

MedGen UID:
11551
•Concept ID:
C0037930
•
Neoplastic Process
Synonym: Spinal cord neoplasm
SNOMED CT: Neoplasm of spinal cord (126962006); Spinal tumor (126962006); Tumor of spinal cord (126962006)
 
HPO: HP:0010302
Monarch Initiative: MONDO:0021234

Definition

A neoplasm affecting the spinal cord. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSpinal cord tumor

Conditions with this feature

Schwannomatosis 2
MedGen UID:
816613
•Concept ID:
C3810283
•
Disease or Syndrome
Schwannomatosis is characterized by a predisposition to develop multiple schwannomas and, less frequently, meningiomas. Individuals with schwannomatosis most commonly present between the second and fourth decade of life. The most common presenting feature is localized or diffuse pain or asymptomatic mass. Schwannomas most often affect peripheral nerves and spinal nerves. Meningiomas occur in about 5% of individuals with schwannomatosis and have only been reported in individuals with SMARCB1-related schwannomatosis. Malignancy remains a theoretic risk especially in individuals with a SMARCB1 pathogenic variant.
See: Condition Record
Schwannomatosis 1
MedGen UID:
887689
•Concept ID:
C4048809
•
Neoplastic Process
Schwannomatosis is characterized by a predisposition to develop multiple schwannomas and, less frequently, meningiomas. Individuals with schwannomatosis most commonly present between the second and fourth decade of life. The most common presenting feature is localized or diffuse pain or asymptomatic mass. Schwannomas most often affect peripheral nerves and spinal nerves. Meningiomas occur in about 5% of individuals with schwannomatosis and have only been reported in individuals with SMARCB1-related schwannomatosis. Malignancy remains a theoretic risk especially in individuals with a SMARCB1 pathogenic variant.
See: Condition Record
Schwannomatosis 1
Schwannomatosis 2

Professional guidelines

PubMed

Understanding spinal cord astrocytoma: Molecular mechanism, therapy, and comprehensive management.
Pang B, An S, Liu Y, Jiang T, Jia W, Chai R, Wang Y
Cancer Lett 2024 Oct 1;601:217154. Epub 2024 Aug 8 doi: 10.1016/j.canlet.2024.217154. PMID: 39121902
Surgical Management of Intramedullary Spinal Cord Tumors.
Hussain I, Parker WE, Barzilai O, Bilsky MH
Neurosurg Clin N Am 2020 Apr;31(2):237-249. Epub 2020 Jan 31 doi: 10.1016/j.nec.2019.12.004. PMID: 32147015
Overview on Criteria for MEP Monitoring.
MacDonald DB
J Clin Neurophysiol 2017 Jan;34(1):4-11. doi: 10.1097/WNP.0000000000000302. PMID: 28045852

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023

Recent clinical studies

Etiology

The Epidemiology of Brain and Spinal Cord Tumors.
Shobeiri P, Seyedmirzaei H, Kalantari A, Mohammadi E, Rezaei N, Hanaei S
Adv Exp Med Biol 2023;1394:19-39. doi: 10.1007/978-3-031-14732-6_2. PMID: 36587379
Intraoperative neurophysiology in intramedullary spinal cord tumor surgery.
Sala F, Skrap B, Kothbauer KF, Deletis V
Handb Clin Neurol 2022;186:229-244. doi: 10.1016/B978-0-12-819826-1.00019-3. PMID: 35772888
Spinal Cord Tumor Surgery.
Walha S, Fairbanks SL
Anesthesiol Clin 2021 Mar;39(1):139-149. doi: 10.1016/j.anclin.2020.11.012. PMID: 33563377
Spinal Cord Tumor Microenvironment.
Rauschenbach L
Adv Exp Med Biol 2020;1226:97-109. doi: 10.1007/978-3-030-36214-0_8. PMID: 32030679
Neuromonitoring for Intramedullary Spinal Cord Tumor Surgery.
Verla T, Fridley JS, Khan AB, Mayer RR, Omeis I
World Neurosurg 2016 Nov;95:108-116. Epub 2016 Jul 26 doi: 10.1016/j.wneu.2016.07.066. PMID: 27474459

Diagnosis

Malignant Spinal Tumors.
Noureldine MHA, Shimony N, Jallo GI
Adv Exp Med Biol 2023;1405:565-581. doi: 10.1007/978-3-031-23705-8_22. PMID: 37452954
Conventional and Advanced Imaging of Spinal Cord Tumors.
Shah LM, Salzman KL
Neuroimaging Clin N Am 2023 Aug;33(3):389-406. Epub 2023 May 18 doi: 10.1016/j.nic.2023.03.001. PMID: 37356858
Intraoperative neurophysiology in intramedullary spinal cord tumor surgery.
Sala F, Skrap B, Kothbauer KF, Deletis V
Handb Clin Neurol 2022;186:229-244. doi: 10.1016/B978-0-12-819826-1.00019-3. PMID: 35772888
Spinal Cord Tumor Surgery.
Walha S, Fairbanks SL
Anesthesiol Clin 2021 Mar;39(1):139-149. doi: 10.1016/j.anclin.2020.11.012. PMID: 33563377
Neoplastic myelopathies.
Chamberlain MC
Continuum (Minneap Minn) 2015 Feb;21(1 Spinal Cord Disorders):132-45. doi: 10.1212/01.CON.0000461089.02113.1b. PMID: 25651222

Therapy

An emerging role of inflammasomes in spinal cord injury and spinal cord tumor.
Chen J, Shen Y, Shao X, Wu W
Front Immunol 2023;14:1119591. Epub 2023 Mar 9 doi: 10.3389/fimmu.2023.1119591. PMID: 36969234Free PMC Article
The Role of Nanotechnology in Spinal Cord Tumors.
Caffo M, Caruso G, Laera R, Curcio A, Cacciola F, Esposito E, Germanò A
Adv Exp Med Biol 2023;1394:193-207. doi: 10.1007/978-3-031-14732-6_12. PMID: 36587389
Postoperative spinal deformity and instability after cervical spinal cord tumor resection in adults: A systematic review and meta-analysis.
Noh SH, Takahashi T, Inoue T, Park SM, Hanakita J, Minami M, Kanematsu R, Shimauchi-Ohtaki H, Ha Y
J Clin Neurosci 2022 Jun;100:148-154. Epub 2022 Apr 23 doi: 10.1016/j.jocn.2022.04.005. PMID: 35472680
Intramedullary spinal cord tumors: a review of current and future treatment strategies.
Tobin MK, Geraghty JR, Engelhard HH, Linninger AA, Mehta AI
Neurosurg Focus 2015 Aug;39(2):E14. doi: 10.3171/2015.5.FOCUS15158. PMID: 26235012
Neoplastic myelopathies.
Chamberlain MC
Continuum (Minneap Minn) 2015 Feb;21(1 Spinal Cord Disorders):132-45. doi: 10.1212/01.CON.0000461089.02113.1b. PMID: 25651222

Prognosis

The Epidemiology of Brain and Spinal Cord Tumors.
Shobeiri P, Seyedmirzaei H, Kalantari A, Mohammadi E, Rezaei N, Hanaei S
Adv Exp Med Biol 2023;1394:19-39. doi: 10.1007/978-3-031-14732-6_2. PMID: 36587379
Intraoperative neurophysiology in intramedullary spinal cord tumor surgery.
Sala F, Skrap B, Kothbauer KF, Deletis V
Handb Clin Neurol 2022;186:229-244. doi: 10.1016/B978-0-12-819826-1.00019-3. PMID: 35772888
Spinal cord astrocytomas: progresses in experimental and clinical investigations for developing recovery neurobiology-based novel therapies.
Teng YD, Abd-El-Barr M, Wang L, Hajiali H, Wu L, Zafonte RD
Exp Neurol 2019 Jan;311:135-147. Epub 2018 Sep 21 doi: 10.1016/j.expneurol.2018.09.010. PMID: 30243796
Neuromonitoring for Intramedullary Spinal Cord Tumor Surgery.
Verla T, Fridley JS, Khan AB, Mayer RR, Omeis I
World Neurosurg 2016 Nov;95:108-116. Epub 2016 Jul 26 doi: 10.1016/j.wneu.2016.07.066. PMID: 27474459
Intramedullary spinal cord tumors: a review of current and future treatment strategies.
Tobin MK, Geraghty JR, Engelhard HH, Linninger AA, Mehta AI
Neurosurg Focus 2015 Aug;39(2):E14. doi: 10.3171/2015.5.FOCUS15158. PMID: 26235012

Clinical prediction guides

Approaches to Incidental Intradural Tumors of the Spine in the Pediatric Population.
Hersh AM, Lubelski D, Theodore N, Sciubba DM, Jallo G, Shimony N
Pediatr Neurosurg 2023;58(5):367-378. Epub 2023 Mar 22 doi: 10.1159/000530286. PMID: 36948181
Intraoperative neurophysiology in intramedullary spinal cord tumor surgery.
Sala F, Skrap B, Kothbauer KF, Deletis V
Handb Clin Neurol 2022;186:229-244. doi: 10.1016/B978-0-12-819826-1.00019-3. PMID: 35772888
Spinal Hemangioblastomas and Neuropathic Pain.
Etli MU, Sarıkaya C, Onen MR, Naderi S
World Neurosurg 2021 May;149:e780-e784. Epub 2021 Feb 1 doi: 10.1016/j.wneu.2021.01.100. PMID: 33540101
Intraoperative neurophysiological mapping and monitoring in spinal tumor surgery: sirens or indispensable tools?
Scibilia A, Terranova C, Rizzo V, Raffa G, Morelli A, Esposito F, Mallamace R, Buda G, Conti A, Quartarone A, Germanò A
Neurosurg Focus 2016 Aug;41(2):E18. doi: 10.3171/2016.5.FOCUS16141. PMID: 27476842
Neuromonitoring for Intramedullary Spinal Cord Tumor Surgery.
Verla T, Fridley JS, Khan AB, Mayer RR, Omeis I
World Neurosurg 2016 Nov;95:108-116. Epub 2016 Jul 26 doi: 10.1016/j.wneu.2016.07.066. PMID: 27474459

Recent systematic reviews

Postoperative spinal deformity and instability after cervical spinal cord tumor resection in adults: A systematic review and meta-analysis.
Noh SH, Takahashi T, Inoue T, Park SM, Hanakita J, Minami M, Kanematsu R, Shimauchi-Ohtaki H, Ha Y
J Clin Neurosci 2022 Jun;100:148-154. Epub 2022 Apr 23 doi: 10.1016/j.jocn.2022.04.005. PMID: 35472680
Novel Clinical Insights into Spinal Hemangioblastoma in Adults: A Systematic Review.
Jankovic D, Hanissian A, Rotim K, Splavski B, Arnautovic KI
World Neurosurg 2022 Feb;158:1-10. Epub 2021 Oct 21 doi: 10.1016/j.wneu.2021.10.105. PMID: 34687932
Hydrocephalus in primary intradural spinal cord tumors: a systematic review of the literature in the pediatric population.
Lampros M, Voulgaris S, Alexiou GA
Neurosurg Rev 2021 Aug;44(4):2079-2084. Epub 2020 Sep 11 doi: 10.1007/s10143-020-01386-0. PMID: 32918116
Surgical outcomes of pediatric spinal cord astrocytomas: systematic review and meta-analysis.
Azad TD, Pendharkar AV, Pan J, Huang Y, Li A, Esparza R, Mehta S, Connolly ID, Veeravagu A, Campen CJ, Cheshier SH, Edwards MSB, Fisher PG, Grant GA
J Neurosurg Pediatr 2018 Oct;22(4):404-410. Epub 2018 Jul 20 doi: 10.3171/2018.4.PEDS17587. PMID: 30028275
A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord.
Konar SK, Bir SC, Maiti TK, Nanda A
J Neurosurg Pediatr 2017 Feb;19(2):239-248. Epub 2016 Nov 4 doi: 10.3171/2016.8.PEDS1631. PMID: 27813458

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Central Nervous System Cancers, 2023

    Consumer resources

    Reviews

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