GEO DataSets

(Submitter supplied) Many eIF4F subunits and PABP paralogues are found in trypanosomes: six eIF4E, five eIF4G, one eIF4A and two PABPs. They are expressed simultaneously and assemble into different complexes, contrasting the situation in metazoans that use distinct complexes in different cell types or developmental stages. Each eIF4F complex has its own proteins, mRNAs and, consequently, a distinct function. We set out to study the function and regulation of the two major eIF4F complexes of Trypanosoma cruzi. more...

Organism:

Trypanosoma cruzi

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL34379

65 Samples

Download data: TXT

(Submitter supplied) Antibody recognition of Trypanosoma cruzi conserved proteins was assessed by evaluating pools of patient IgG samples on microarrays of 400,000 peptides covering these proteins as 15-mers with an overlap of 13 amino acids.

Organism:

Homo sapiens; Trypanosoma cruzi

Type:

Protein profiling by protein array

Platform:

GPL33498

3 Samples

Download data: TXT

(Submitter supplied) We adapted the widely used digestion of chromatin with micrococcal nuclease (MNase) followed by deep sequencing to the parasite Trypanosoma cruzi, which presents numerous singularities. In this work, we use the hybrid CL Brener strain carrying two set of chromosomes from two substantially different parental strains. The hybrid strain CL Brener is composed of the Esmeraldo-like and non Esmeraldo-like haplotypes. more...

Organism:

Trypanosoma cruzi

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL30239

4 Samples

Download data: BW, TXT

(Submitter supplied) Comparative genomic analysis of T. cruzi CLB vs Trypanosoma rangeli (strains SC, Choachí, C23, H14, R1625 and PIT10) and Trypanosoma conorhini

Organism:

Trypanosoma cruzi; Trypanosoma rangeli; Trypanosoma conorhini

Type:

Genome variation profiling by array

Platform:

GPL32014

16 Samples

Download data: TXT, XLSX

(Submitter supplied) Comparative genomic analysis of Trypanosoma cruzi G with Trypanosoma cruzi D11.

Organism:

Trypanosoma cruzi

Type:

Genome variation profiling by array

Platform:

GPL32014

4 Samples

Download data: TXT

(Submitter supplied) Using the Deep Seq transcriptome sequencing we characterized the heme induced transcriptome of epimastigotes and determined that most of the upregulated genes were related to glucose metabolism inside the glycosomes.

Organism:

Trypanosoma cruzi

Type:

Expression profiling by high throughput sequencing

Platform:

GPL27740

5 Samples

Download data: TXT

(Submitter supplied) Chagas disease is a notorious public health problem worldwide. However, the pathology is still poorly understood in humans and dendritic cells (DCs) have a determinant role during infection that could help to understand what happens with immune response during the first contact. Here we performed a transcriptomic analysis of the interaction between DCs from three human donors and the infective forms of T. more...

Organism:

Homo sapiens; Trypanosoma cruzi

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL16791 GPL29219

12 Samples

Download data: XLS

(Submitter supplied) Adhesion of T. cruzi trypomastigotes to components of the extracellular matrix (ECM) is an important step in mammalian host cell invasion. We have recently described a significant increase in the tyrosine nitration levels of histones H2A and H4 when trypomastigotes are incubated with components of the ECM. In this work, we used chromatin immunoprecipitation (ChIP) with an anti-nitro-tyrosine antibody followed by mass spectrometry to identify nitrated DNA binding proteins in T. more...

Organism:

Trypanosoma cruzi

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL27740

4 Samples

Download data: BEDGRAPH

(Submitter supplied) TcRBP7 and TcRBP40 proteins are adjacent paralogs in T. cruzi with a conserved RRM structure and similar protein localization at specific foci at the posterior region. We identified their targets in order to compare their function, infering about the evolutionary implication of regulatory proteins duplication. Surprisingly, the mRNA targets co-immunoprecipitated with each RBP were distinct, pointing to a subfunctionalization outcome. more...

Organism:

Trypanosoma cruzi

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23054

9 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Gallus gallus; Oryctolagus cuniculus; Mus musculus; Human immunodeficiency virus 1; unidentified; Megathura crenulata; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens; Sus scrofa domesticus; Quercus alba; Trypanosoma cruzi; Bothrops moojeni; Pachymenia carnosa; Rhodotorula; Bos taurus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius

Type:

Protein profiling by protein array

Platforms:

GPL23566 GPL23565

55 Samples

Download data: GPR

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Quercus alba; Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ceratonia siliqua; Bothrops moojeni; Senegalia senegal; Dermestes lardarius; Ovis aries; Oryctolagus cuniculus; Megathura crenulata; Frangula alnus; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Trypanosoma cruzi; Gallus gallus; Pachymenia carnosa

Type:

Protein profiling by protein array

Platform:

GPL23566

7 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Quercus alba; Oryctolagus cuniculus; Megathura crenulata

Type:

Protein profiling by protein array

Platform:

GPL23566

7 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Quercus alba; Gossypium hirsutum; Oryctolagus cuniculus; Megathura crenulata; Homo sapiens; Bos taurus; Rhodotorula; Trypanosoma cruzi; Gallus gallus; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Pachymenia carnosa

Type:

Protein profiling by protein array

Platform:

GPL23566

7 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Gallus gallus; Sus scrofa domesticus; Ovis aries; Oryctolagus cuniculus; Ceratonia siliqua; Megathura crenulata; Frangula alnus; Rhodotorula; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Dermestes lardarius; Trypanosoma cruzi; Bos taurus; Quercus alba; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens

Type:

Protein profiling by protein array

Platform:

GPL23566

7 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Pandalus borealis; Oncorhynchus nerka; Sus scrofa domesticus; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Quercus alba; Oryctolagus cuniculus; Megathura crenulata; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Trypanosoma cruzi; Gallus gallus; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Pachymenia carnosa

Type:

Protein profiling by protein array

Platform:

GPL23566

7 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Pandalus borealis; Gallus gallus; Sus scrofa domesticus; Ovis aries; Oryctolagus cuniculus; Ceratonia siliqua; Megathura crenulata; Frangula alnus; Dermestes lardarius; Rhodotorula; Trypanosoma cruzi; Mus musculus; Human immunodeficiency virus 1; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Homo sapiens; Bos taurus; Quercus alba; Gossypium hirsutum; Oncorhynchus nerka

Type:

Protein profiling by protein array

Platform:

GPL23566

14 Samples

Download data: GPR, TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to evaluate the immunological evolution of antibodies to the glyco-antigen GD2. The goal is to determine germline and affinity mature antibody specificity and affinities/ Results: Affinity mature anti-GD2 antibodies 3F8 and ch14.18 had high affinity and were highly specific for the target GD2. Germline antibodies were also hihgly specific and had surprisingly high affinity. more...

Organism:

Gallus gallus; Ovis aries; Oryctolagus cuniculus; unidentified; Megathura crenulata; Frangula alnus; Quercus alba; Gossypium hirsutum; Pandalus borealis; Oncorhynchus nerka; Homo sapiens; Sus scrofa domesticus; Trypanosoma cruzi; Rhodotorula; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Ceratonia siliqua; Bothrops moojeni; Senegalia senegal; Pachymenia carnosa; Dermestes lardarius

Type:

Protein profiling by protein array

Platform:

GPL23565

6 Samples

Download data: GPR, TXT

(Submitter supplied) We have developed a method of mRNA amplification based on T7 polymerase, where T7 promoter is attached to a oligonucleotide containing the mini-exon sequence, which will hybridize with cDNA molecules containing the anti-ME sequence

Organism:

Trypanosoma cruzi; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23054 GPL11154

46 Samples

Download data: TXT

(Submitter supplied) Purpose: This study uses a high-throughput glycan microarray to profile anti-glycan immune responses to whole-cell vaccines: GVAX Pancreas, K562-GM and H1299. The aim was to indentify anti-glycan antibody responses relevent to patient clinical outcomes Results: Immune responses to non-human antigens bovine fetuin and alpha-Gal antigens were identified induced by GVAX Pancreas. The magnitude of these responses inversely correlate with patient survival. more...

Organism:

Gossypium hirsutum; Homo sapiens; Bos taurus; Mus musculus; Human immunodeficiency virus 1; Pandalus borealis; Oncorhynchus nerka; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Quercus alba; Oryctolagus cuniculus; Megathura crenulata; Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa

Type:

Other

Platform:

GPL21991

168 Samples

Download data: GPR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Pandalus borealis; Oncorhynchus nerka; Ovis aries; Ceratonia siliqua; Frangula alnus; Senegalia senegal; Dermestes lardarius; Gossypium hirsutum; Rhodotorula; Homo sapiens; Bos taurus; Mus musculus; Trypanosoma cruzi; Gallus gallus; Bothrops moojeni; Pachymenia carnosa; Quercus alba; Megathura crenulata

Type:

Other

Platforms:

GPL20117 GPL20116

331 Samples

Download data