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Thymus cancer

MedGen UID:
155883
•Concept ID:
C0751552
•
Neoplastic Process
Synonyms: Cancer of the Thymus; Cancer of Thymus; Cancer, Thymic; Cancer, Thymus; Cancers, Thymic; Cancers, Thymus; Thymic Cancer; Thymic Cancers; Thymus Cancer; Thymus Cancers
SNOMED CT: Malignant tumor of thymus (363434003)
 
Monarch Initiative: MONDO:0002586

Definition

A primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymus cancer

Professional guidelines

PubMed

The diagnosis of severe combined immunodeficiency (SCID): The Primary Immune Deficiency Treatment Consortium (PIDTC) 2022 Definitions.
Dvorak CC, Haddad E, Heimall J, Dunn E, Buckley RH, Kohn DB, Cowan MJ, Pai SY, Griffith LM, Cuvelier GDE, Eissa H, Shah AJ, O'Reilly RJ, Pulsipher MA, Wright NAM, Abraham RS, Satter LF, Notarangelo LD, Puck JM
J Allergy Clin Immunol 2023 Feb;151(2):539-546. Epub 2022 Nov 28 doi: 10.1016/j.jaci.2022.10.022. PMID: 36456361Free PMC Article
Thymic Malignancy-Updates in Staging and Management.
Rappaport JMP, Huang J, Ahmad U
Surg Oncol Clin N Am 2020 Oct;29(4):581-601. Epub 2020 Aug 11 doi: 10.1016/j.soc.2020.06.010. PMID: 32883460
Advances in the understanding and treatment of sepsis-induced immunosuppression.
Venet F, Monneret G
Nat Rev Nephrol 2018 Feb;14(2):121-137. Epub 2017 Dec 11 doi: 10.1038/nrneph.2017.165. PMID: 29225343

Recent clinical studies

Etiology

Covid-19 vaccines elicit effective IgG responses in an elderly thymus cancer patient with chemotherapy.
Koller A, Szebeni J
Hum Vaccin Immunother 2023 Dec 31;19(1):2188035. Epub 2023 Apr 16 doi: 10.1080/21645515.2023.2188035. PMID: 37062957Free PMC Article
Lifetime Exposure to Welding Fumes and Risk of Some Rare Cancers.
Kendzia B, Kaerlev L, Ahrens W, Merletti F, Eriksson M, Guénel P, Lynge E, Costa-Pereira A, Morales Suárez-Varela M, Jöckel KH, Stang A, Behrens T
Am J Epidemiol 2022 Sep 28;191(10):1753-1765. doi: 10.1093/aje/kwac123. PMID: 35872594
Tobacco smoking and alcohol consumption as risk factors for thymoma - A European case-control study.
Eriksson M, Kaerlev L, Johansen P, Afonso N, Ahrens W, Costa-Pereira A, Guénel P, Jöckel KH, Gonzalez AL, Merletti F, Suárez-Varela MM, Trétarre B, Wingren G, Richiardi L, Sabroe S
Cancer Epidemiol 2019 Aug;61:133-138. Epub 2019 Jun 26 doi: 10.1016/j.canep.2019.06.008. PMID: 31254794
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: a population-based cohort study.
Yeh JH, Lin CC, Chen YK, Sung FC, Chiu HC, Kao CH
Neuromuscul Disord 2014 Mar;24(3):245-9. Epub 2013 Nov 22 doi: 10.1016/j.nmd.2013.11.007. PMID: 24332676
Thymus cancer epidemiology in England and Wales.
dos Santos Silva I, Swerdlow AJ
Br J Cancer 1990 Jun;61(6):899-902. doi: 10.1038/bjc.1990.201. PMID: 2372494Free PMC Article

Diagnosis

Six cases report of differential diagnosis of periapical diseases.
Xia WW, Zhu YQ, Wang XY
Int J Oral Sci 2011 Jul;3(3):153-9. doi: 10.4248/IJOS11055. PMID: 21789964Free PMC Article

Therapy

Lifetime Exposure to Welding Fumes and Risk of Some Rare Cancers.
Kendzia B, Kaerlev L, Ahrens W, Merletti F, Eriksson M, Guénel P, Lynge E, Costa-Pereira A, Morales Suárez-Varela M, Jöckel KH, Stang A, Behrens T
Am J Epidemiol 2022 Sep 28;191(10):1753-1765. doi: 10.1093/aje/kwac123. PMID: 35872594
De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
Tobacco smoking and alcohol consumption as risk factors for thymoma - A European case-control study.
Eriksson M, Kaerlev L, Johansen P, Afonso N, Ahrens W, Costa-Pereira A, Guénel P, Jöckel KH, Gonzalez AL, Merletti F, Suárez-Varela MM, Trétarre B, Wingren G, Richiardi L, Sabroe S
Cancer Epidemiol 2019 Aug;61:133-138. Epub 2019 Jun 26 doi: 10.1016/j.canep.2019.06.008. PMID: 31254794
First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13).
Wicki A, Brown N, Xyrafas A, Bize V, Hawle H, Berardi S, Cmiljanović N, Cmiljanović V, Stumm M, Dimitrijević S, Herrmann R, Prêtre V, Ritschard R, Tzankov A, Hess V, Childs A, Hierro C, Rodon J, Hess D, Joerger M, von Moos R, Sessa C, Kristeleit R
Eur J Cancer 2018 Jun;96:6-16. Epub 2018 Apr 13 doi: 10.1016/j.ejca.2018.03.012. PMID: 29660598
Sunitinib effective for rare thymus cancer.
Cancer Discov 2015 Apr;5(4):340. Epub 2015 Feb 13 doi: 10.1158/2159-8290.CD-NB2015-017. PMID: 25680712

Prognosis

Characterization of SLC34A2 as a Potential Prognostic Marker of Oncological Diseases.
Vlasenkova R, Nurgalieva A, Akberova N, Bogdanov M, Kiyamova R
Biomolecules 2021 Dec 14;11(12) doi: 10.3390/biom11121878. PMID: 34944522Free PMC Article

Clinical prediction guides

De novo hepatocellular carcinoma in a non-cirrhotic allograft 27 years after liver transplantation: A case report.
El-Domiaty N, Saliba F, Sebagh M, Salloum C, Vibert E, Azoulay D, Hamelin J, Cherqui D, Adam R, Samuel D
Am J Transplant 2021 May;21(5):1953-1958. Epub 2021 Jan 23 doi: 10.1111/ajt.16476. PMID: 33382179
First-in human, phase 1, dose-escalation pharmacokinetic and pharmacodynamic study of the oral dual PI3K and mTORC1/2 inhibitor PQR309 in patients with advanced solid tumors (SAKK 67/13).
Wicki A, Brown N, Xyrafas A, Bize V, Hawle H, Berardi S, Cmiljanović N, Cmiljanović V, Stumm M, Dimitrijević S, Herrmann R, Prêtre V, Ritschard R, Tzankov A, Hess V, Childs A, Hierro C, Rodon J, Hess D, Joerger M, von Moos R, Sessa C, Kristeleit R
Eur J Cancer 2018 Jun;96:6-16. Epub 2018 Apr 13 doi: 10.1016/j.ejca.2018.03.012. PMID: 29660598
Excessive risk of cancer and in particular lymphoid malignancy in myasthenia gravis patients: a population-based cohort study.
Yeh JH, Lin CC, Chen YK, Sung FC, Chiu HC, Kao CH
Neuromuscul Disord 2014 Mar;24(3):245-9. Epub 2013 Nov 22 doi: 10.1016/j.nmd.2013.11.007. PMID: 24332676

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