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Metastatic Malignant Head and Neck Neoplasm

MedGen UID:
1740038
•Concept ID:
C5418572
•
Neoplastic Process

Definition

A malignant neoplasm that arises from the head and neck region and has spread to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Head and Neck Neoplasm

Professional guidelines

PubMed

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Uveal melanoma: From diagnosis to treatment and the science in between.
Chattopadhyay C, Kim DW, Gombos DS, Oba J, Qin Y, Williams MD, Esmaeli B, Grimm EA, Wargo JA, Woodman SE, Patel SP
Cancer 2016 Aug 1;122(15):2299-312. Epub 2016 Mar 15 doi: 10.1002/cncr.29727. PMID: 26991400Free PMC Article
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Management of Regional Lymph Nodes in Head and Neck Melanoma.
Glaun MDE, Feng Z, Lango M
Oral Maxillofac Surg Clin North Am 2022 May;34(2):273-281. Epub 2022 Apr 7 doi: 10.1016/j.coms.2021.11.001. PMID: 35400571
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Mucosal melanomas.
Tomicic J, Wanebo HJ
Surg Clin North Am 2003 Apr;83(2):237-52. doi: 10.1016/S0039-6109(02)00100-7. PMID: 12744608

Diagnosis

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Cancer of unknown primary in the head and neck: Diagnosis and treatment.
Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Chemotherapy and immunotherapy for recurrent and metastatic head and neck cancer: a systematic review.
Guidi A, Codecà C, Ferrari D
Med Oncol 2018 Feb 13;35(3):37. doi: 10.1007/s12032-018-1096-5. PMID: 29441454
Metastatic neck disease.
Yeoh MS, Smart RJ, Ghali GE
Atlas Oral Maxillofac Surg Clin North Am 2015 Mar;23(1):95-104. Epub 2014 Dec 8 doi: 10.1016/j.cxom.2014.10.003. PMID: 25707568

Therapy

SEOM clinical guidelines for the treatment of head and neck cancer (2020).
Mesia R, Iglesias L, Lambea J, Martínez-Trufero J, Soria A, Taberna M, Trigo J, Chaves M, García-Castaño A, Cruz J
Clin Transl Oncol 2021 May;23(5):913-921. Epub 2021 Feb 26 doi: 10.1007/s12094-020-02533-1. PMID: 33635468Free PMC Article
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group.
Lacas B, Carmel A, Landais C, Wong SJ, Licitra L, Tobias JS, Burtness B, Ghi MG, Cohen EEW, Grau C, Wolf G, Hitt R, Corvò R, Budach V, Kumar S, Laskar SG, Mazeron JJ, Zhong LP, Dobrowsky W, Ghadjar P, Fallai C, Zakotnik B, Sharma A, Bensadoun RJ, Ruo Redda MG, Racadot S, Fountzilas G, Brizel D, Rovea P, Argiris A, Nagy ZT, Lee JW, Fortpied C, Harris J, Bourhis J, Aupérin A, Blanchard P, Pignon JP; MACH-NC Collaborative Group
Radiother Oncol 2021 Mar;156:281-293. Epub 2021 Jan 27 doi: 10.1016/j.radonc.2021.01.013. PMID: 33515668Free PMC Article
Palliative Radiation Therapy for Head and Neck Cancers.
Grewal AS, Jones J, Lin A
Int J Radiat Oncol Biol Phys 2019 Oct 1;105(2):254-266. Epub 2019 May 22 doi: 10.1016/j.ijrobp.2019.05.024. PMID: 31128145
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study.
Cohen EEW, Soulières D, Le Tourneau C, Dinis J, Licitra L, Ahn MJ, Soria A, Machiels JP, Mach N, Mehra R, Burtness B, Zhang P, Cheng J, Swaby RF, Harrington KJ; KEYNOTE-040 investigators
Lancet 2019 Jan 12;393(10167):156-167. Epub 2018 Nov 30 doi: 10.1016/S0140-6736(18)31999-8. PMID: 30509740
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Prognosis

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Leiomyosarcoma: Prognostic outline of a rare head and neck malignancy.
Saluja TS, Iyer J, Singh SK
Oral Oncol 2019 Aug;95:100-105. Epub 2019 Jun 13 doi: 10.1016/j.oraloncology.2019.06.010. PMID: 31345375
Cutaneous Head and Neck Malignancies in the Elderly.
Hughley BB, Schmalbach CE
Clin Geriatr Med 2018 May;34(2):245-258. Epub 2018 Feb 17 doi: 10.1016/j.cger.2018.01.004. PMID: 29661336
Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial.
Seiwert TY, Burtness B, Mehra R, Weiss J, Berger R, Eder JP, Heath K, McClanahan T, Lunceford J, Gause C, Cheng JD, Chow LQ
Lancet Oncol 2016 Jul;17(7):956-965. Epub 2016 May 27 doi: 10.1016/S1470-2045(16)30066-3. PMID: 27247226
Pharyngocutaneous fistula.
Mäkitie AA, Irish J, Gullane PJ
Curr Opin Otolaryngol Head Neck Surg 2003 Apr;11(2):78-84. doi: 10.1097/00020840-200304000-00003. PMID: 14515083

Clinical prediction guides

A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer.
Schinke H, Shi E, Lin Z, Quadt T, Kranz G, Zhou J, Wang H, Hess J, Heuer S, Belka C, Zitzelsberger H, Schumacher U, Genduso S, Riecken K, Gao Y, Wu Z, Reichel CA, Walz C, Canis M, Unger K, Baumeister P, Pan M, Gires O
Mol Cancer 2022 Sep 8;21(1):178. doi: 10.1186/s12943-022-01646-1. PMID: 36076232Free PMC Article
Prognostic and Predictive Factors in Advanced Head and Neck Squamous Cell Carcinoma.
Magnes T, Wagner S, Kiem D, Weiss L, Rinnerthaler G, Greil R, Melchardt T
Int J Mol Sci 2021 May 7;22(9) doi: 10.3390/ijms22094981. PMID: 34067112Free PMC Article
Biomarkers for immunotherapy response in head and neck cancer.
Gavrielatou N, Doumas S, Economopoulou P, Foukas PG, Psyrri A
Cancer Treat Rev 2020 Mar;84:101977. Epub 2020 Jan 24 doi: 10.1016/j.ctrv.2020.101977. PMID: 32018128
Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell 2017 Dec 14;171(7):1611-1624.e24. Epub 2017 Nov 30 doi: 10.1016/j.cell.2017.10.044. PMID: 29198524Free PMC Article
Cetuximab in metastatic or recurrent head and neck cancer: the EXTREME trial.
Rivera F, García-Castaño A, Vega N, Vega-Villegas ME, Gutiérrez-Sanz L
Expert Rev Anticancer Ther 2009 Oct;9(10):1421-8. doi: 10.1586/era.09.113. PMID: 19828002

Recent systematic reviews

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.
Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Association between immune-related side effects and efficacy and benefit of immune checkpoint inhibitors - A systematic review and meta-analysis.
Hussaini S, Chehade R, Boldt RG, Raphael J, Blanchette P, Maleki Vareki S, Fernandes R
Cancer Treat Rev 2021 Jan;92:102134. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102134. PMID: 33302134
Prevalence of pain in patients with cancer: a systematic review of the past 40 years.
van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, Schouten HC, van Kleef M, Patijn J
Ann Oncol 2007 Sep;18(9):1437-49. Epub 2007 Mar 12 doi: 10.1093/annonc/mdm056. PMID: 17355955

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