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Thymic epithelial neoplasm

MedGen UID:
220416
Concept ID:
C1266101
Neoplastic Process
Synonyms: Epithelial tumor of thymus; Thymic epithelial tumor; Thymoma, adult
SNOMED CT: Thymic epithelial neoplasm (128621008)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0018079
Orphanet: ORPHA3398

Definition

Thymic epithelial neoplasms (TEN) are rare malignancies arising from the epithelium of the thymic gland. They comprise three sub-types: thymoma, thymic carcinoma, and thymic neuroendocrine carcinoma (see these terms). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThymic epithelial neoplasm
Follow this link to review classifications for Thymic epithelial neoplasm in Orphanet.

Professional guidelines

PubMed

Baudin E, Caplin M, Garcia-Carbonero R, Fazio N, Ferolla P, Filosso PL, Frilling A, de Herder WW, Hörsch D, Knigge U, Korse CM, Lim E, Lombard-Bohas C, Pavel M, Scoazec JY, Sundin A, Berruti A; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2021 Apr;32(4):439-451. Epub 2021 Jan 19 doi: 10.1016/j.annonc.2021.01.003. PMID: 33482246
Shintani Y, Funaki S, Ose N, Kanou T, Fukui E, Kimura K, Minami M
Surg Today 2021 Mar;51(3):331-339. Epub 2020 Jul 10 doi: 10.1007/s00595-020-02070-y. PMID: 32647929
Girard N, Merveilleux du Vignaux C
Curr Opin Oncol 2017 Mar;29(2):112-117. doi: 10.1097/CCO.0000000000000355. PMID: 28027106

Recent clinical studies

Etiology

Kim DH, Lim Y, Kim S, Ock CY, Youk J, Kim M, Kim TM, Kim DW, Kim HJ, Koh J, Jung KC, Na KJ, Kang CH, Keam B
Thorac Cancer 2023 Oct;14(30):3001-3011. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15089. PMID: 37675597Free PMC Article
Suster DI, Craig Mackinnon A, DiStasio M, Basu MK, Pihan G, Suster S
Mod Pathol 2022 Jul;35(7):875-894. Epub 2022 Feb 10 doi: 10.1038/s41379-022-01013-x. PMID: 35145198
Kunacheewa C, Wongwiangjunt S, Sukpanichnant S
J Med Case Rep 2022 Jan 12;16(1):10. doi: 10.1186/s13256-021-03225-2. PMID: 35016720Free PMC Article
Weissferdt A, Moran CA
Pathol Res Pract 2015 Jan;211(1):2-11. Epub 2014 Jun 24 doi: 10.1016/j.prp.2014.06.007. PMID: 25441660
Nonaka D, Henley JD, Chiriboga L, Yee H
Am J Surg Pathol 2007 Jul;31(7):1038-44. doi: 10.1097/PAS.0b013e31802b4917. PMID: 17592270

Diagnosis

Kim DH, Lim Y, Kim S, Ock CY, Youk J, Kim M, Kim TM, Kim DW, Kim HJ, Koh J, Jung KC, Na KJ, Kang CH, Keam B
Thorac Cancer 2023 Oct;14(30):3001-3011. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15089. PMID: 37675597Free PMC Article
Garrana SH, Rosado-de-Christenson ML
Radiol Clin North Am 2021 Mar;59(2):155-168. Epub 2021 Jan 11 doi: 10.1016/j.rcl.2020.10.003. PMID: 33551078
Carter BW, Benveniste MF, Truong MT, Marom EM
Magn Reson Imaging Clin N Am 2015 May;23(2):165-77. doi: 10.1016/j.mric.2015.01.005. PMID: 25952513
Weissferdt A, Moran CA
Pathol Res Pract 2015 Jan;211(1):2-11. Epub 2014 Jun 24 doi: 10.1016/j.prp.2014.06.007. PMID: 25441660
Suster S
J Clin Pathol 2006 Dec;59(12):1238-44. Epub 2006 May 5 doi: 10.1136/jcp.2005.031138. PMID: 16679354Free PMC Article

Prognosis

Kim DH, Lim Y, Kim S, Ock CY, Youk J, Kim M, Kim TM, Kim DW, Kim HJ, Koh J, Jung KC, Na KJ, Kang CH, Keam B
Thorac Cancer 2023 Oct;14(30):3001-3011. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15089. PMID: 37675597Free PMC Article
Fang W, Wu CH, Sun QL, Gu ZT, Zhu L, Mao T, Zhang XF, Xu N, Lu TP, Tsai MH, Chen LH, Lai LC, Chuang EY
Front Immunol 2021;12:748820. Epub 2021 Nov 16 doi: 10.3389/fimmu.2021.748820. PMID: 34867976Free PMC Article
Vivero M, Davineni P, Nardi V, Chan JKC, Sholl LM
Mod Pathol 2020 Apr;33(4):560-565. Epub 2019 Oct 22 doi: 10.1038/s41379-019-0382-x. PMID: 31641231
Weissferdt A, Moran CA
Pathol Res Pract 2015 Jan;211(1):2-11. Epub 2014 Jun 24 doi: 10.1016/j.prp.2014.06.007. PMID: 25441660
Suster S
J Clin Pathol 2006 Dec;59(12):1238-44. Epub 2006 May 5 doi: 10.1136/jcp.2005.031138. PMID: 16679354Free PMC Article

Clinical prediction guides

Kim DH, Lim Y, Kim S, Ock CY, Youk J, Kim M, Kim TM, Kim DW, Kim HJ, Koh J, Jung KC, Na KJ, Kang CH, Keam B
Thorac Cancer 2023 Oct;14(30):3001-3011. Epub 2023 Sep 7 doi: 10.1111/1759-7714.15089. PMID: 37675597Free PMC Article
Fang W, Wu CH, Sun QL, Gu ZT, Zhu L, Mao T, Zhang XF, Xu N, Lu TP, Tsai MH, Chen LH, Lai LC, Chuang EY
Front Immunol 2021;12:748820. Epub 2021 Nov 16 doi: 10.3389/fimmu.2021.748820. PMID: 34867976Free PMC Article
Shinya T, Tanaka T, Soh J, Matsushita T, Sato S, Toyooka S, Yoshino T, Miyoshi S, Kanazawa S
Acta Med Okayama 2017 Apr;71(2):105-112. doi: 10.18926/AMO/54978. PMID: 28420891
Roden AC, Yi ES, Jenkins SM, Edwards KK, Donovan JL, Lewis JE, Cassivi SD, Marks RS, Garces YI, Aubry MC
Am J Surg Pathol 2015 Apr;39(4):427-41. doi: 10.1097/PAS.0000000000000391. PMID: 25634747
Suster S
J Clin Pathol 2006 Dec;59(12):1238-44. Epub 2006 May 5 doi: 10.1136/jcp.2005.031138. PMID: 16679354Free PMC Article

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