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Neuroblastic tumor

MedGen UID:: 233228
•Concept ID:: C1334953
•: Neoplastic Process

Synonym:	Neuroblastic tumour

HPO:	HP:0004376
Monarch Initiative:	MONDO:0006316

Definition

A family of tumors arising in the embryonal remnants of the sympathetic nervous system, which includes neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeuroblastic tumor

Pathological process
- Disease
  - Neoplasm
    - Malignant neoplastic disease
      - Malignant neoplasm of nervous system
        Malignant neoplasm of the central nervous system
        Neuroblastic tumor
        Ganglioneuroblastoma
        Central Nervous System Ganglioneuroblastoma
        Childhood Central Nervous System Ganglioneuroblastoma
        Childhood Ganglioneuroblastoma
        Childhood Ganglioneuroblastoma, Intermixed
        Childhood Ganglioneuroblastoma, Nodular
        Intermixed schwannian stroma-rich ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Intermixed
        Nodular ganglioneuroblastoma
        Adrenal Gland Ganglioneuroblastoma, Nodular
        Schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma
        Stroma-dominant and stroma-poor composite ganglioneuroblastoma
        Peripheral ganglioneuroblastoma
        Adrenal gland ganglioneuroblastoma
        Mediastinum ganglioneuroblastoma
        Recurrent Ganglioneuroblastoma
        Refractory Ganglioneuroblastoma
        Neuroblastoma
        Cerebral neuroblastoma
        Childhood Central Nervous System Neuroblastoma
        Childhood Neuroblastoma
        Congenital neuroblastoma
        Differentiating neuroblastoma
        Esthesioneuroblastoma
        Kadish Stage A Olfactory Neuroblastoma
        Kadish Stage B Olfactory Neuroblastoma
        Kadish Stage C Olfactory Neuroblastoma
        Nasal cavity olfactory neuroblastoma
        Recurrent Olfactory Neuroblastoma
        Sinonasal Olfactory Neuroblastoma
        Extracranial neuroblastoma
        Peripheral Neuroblastoma
        Spinal cord neuroblastoma
        Hereditary Neuroblastoma
        High Risk Neuroblastoma
        Localized neuroblastoma
        Metastatic Neuroblastoma
        Neuroblastoma, susceptibility to, 1
        Neuroblastoma, susceptibility to, 2
        Neuroblastoma, susceptibility to, 3
        Poorly Differentiated Neuroblastoma
        Recurrent Neuroblastoma
        Refractory Neuroblastoma
        Regional Neuroblastoma
        Resectable Neuroblastoma
        Localized Resectable Neuroblastoma
        Retinoblastoma
        bilateral retinoblastoma
        Differentiated Retinoblastoma
        Diffuse Retinoblastoma
        Extraocular retinoblastoma
        Hereditary retinoblastoma
        Intraocular retinoblastoma
        Non-hereditary retinoblastoma
        Recurrent Retinoblastoma
        Retinoblastoma by AJCC v8 Stage
        Sporadic Retinoblastoma
        Trilateral retinoblastoma
        Undifferentiated Retinoblastoma
        Unilateral retinoblastoma
        Sellar Neuroblastoma
        Stage 1 Neuroblastoma
        Stage 2 Neuroblastoma
        Stage 2A Neuroblastoma
        Stage 2B Neuroblastoma
        Stage 3 Neuroblastoma
        Stage 4 Neuroblastoma
        Stage 4S Neuroblastoma
        Undifferentiated Neuroblastoma
        Unresectable Neuroblastoma
        Localized Unresectable Neuroblastoma

Professional guidelines

PubMed

DO THE RADIOLOGICAL CRITERIA WITH THE USE OF RISK FACTORS IMPACT THE FORECASTING OF ABDOMINAL NEUROBLASTIC TUMOR RESECTION IN CHILDREN?

Penazzi ACS, Tostes VS, Duarte AAB, Lederman HM, Caran EMM, Abib SCV
Arq Bras Cir Dig 2017 Apr-Jun;30(2):88-92. doi: 10.1590/0102-6720201700020003. PMID: 29257841 Free PMC Article

Early Detection and Treatment of Neuroblastic Tumor with Opsoclonus-Myoclonus Syndrome Improve Neurological Outcome: A Review of Five Cases at a Single Institution in Japan.

Takama Y, Yoneda A, Nakamura T, Nakaoka T, Higashio A, Santo K, Kuki I, Kawawaki H, Tomiwa K, Hara J
Eur J Pediatr Surg 2016 Feb;26(1):54-9. Epub 2015 Sep 26 doi: 10.1055/s-0035-1564714. PMID: 26409265

Outcome prediction and risk assessment by quantitative pyrosequencing methylation analysis of the SFN gene in advanced stage, high-risk, neuroblastic tumor patients.

Banelli B, Bonassi S, Casciano I, Mazzocco K, Di Vinci A, Scaruffi P, Brigati C, Allemanni G, Borzì L, Tonini GP, Romani M
Int J Cancer 2010 Feb 1;126(3):656-68. doi: 10.1002/ijc.24768. PMID: 19626586

See all (4)

Recent clinical studies

Etiology

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Incidence of Horner syndrome associated with neuroblastic disease.

Kuchalska K, Barełkowska M, Derwich K, Jończyk-Potoczna K, Gotz-Więckowska A
Childs Nerv Syst 2021 Apr;37(4):1243-1247. Epub 2020 Nov 10 doi: 10.1007/s00381-020-04966-z. PMID: 33174155 Free PMC Article

Expression of Disialoganglioside (GD2) in Neuroblastic Tumors: A Prognostic Value for Patients Treated With Anti-GD2 Immunotherapy.

Terzic T, Cordeau M, Herblot S, Teira P, Cournoyer S, Beaunoyer M, Peuchmaur M, Duval M, Sartelet H
Pediatr Dev Pathol 2018 Jul-Aug;21(4):355-362. Epub 2017 Oct 25 doi: 10.1177/1093526617723972. PMID: 29067879

Ganglioneuroblastoma in a newborn with multiple metastases: a case report.

Gauchan E, Sharma P, Ghartimagar D, Ghosh A
J Med Case Rep 2017 Aug 29;11(1):239. doi: 10.1186/s13256-017-1397-x. PMID: 28847309 Free PMC Article

Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation.

Kopelman JE, McLean IW, Rosenberg SH
Ophthalmology 1987 Apr;94(4):371-7. doi: 10.1016/s0161-6420(87)33436-0. PMID: 3587919

See all (45)

Diagnosis

Thoracic ganglioneuroma with extension into the epidural space.

Aljuboori Z
Br J Neurosurg 2024 Aug;38(4):948-949. Epub 2021 Aug 27 doi: 10.1080/02688697.2021.1969336. PMID: 34448647

Neuroblastoma Arising in an Immature Teratoma of the Ovary in a 13-Year-Old.

Felicelli C, Gulliver J, Gray C, Khramtsov A, Blanco LZ Jr, Wadhwani NR
Pediatr Dev Pathol 2023 Jan-Feb;26(1):72-76. Epub 2022 Nov 30 doi: 10.1177/10935266221129087. PMID: 36448449

Mediastinal neuroblastoma, ganglioneuroblastoma, and ganglioneuroma: Pathology review and diagnostic approach.

Choi JH, Ro JY
Semin Diagn Pathol 2022 Mar;39(2):120-130. Epub 2021 Jun 15 doi: 10.1053/j.semdp.2021.06.007. PMID: 34167847

Neuroblastoma of the Lumbar Spine.

Hung B, Pennington Z, Sciubba DM
World Neurosurg 2021 Jul;151:2-4. Epub 2021 Apr 2 doi: 10.1016/j.wneu.2021.03.137. PMID: 33819706

Incidence of Horner syndrome associated with neuroblastic disease.

See all (67)

Therapy

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Expression of Disialoganglioside (GD2) in Neuroblastic Tumors: A Prognostic Value for Patients Treated With Anti-GD2 Immunotherapy.

Successful treatment of trilateral retinoblastoma with conventional and high-dose chemotherapy plus radiotherapy: a case report.

De Ioris MA, Fidani P, Munier FL, Serra A, Ilari I, Popovic MB, Natali G, Secco DE, Cozza R
J Pediatr Hematol Oncol 2010 Nov;32(8):e343-5. doi: 10.1097/MPH.0b013e3181e90031. PMID: 20881869

Trilateral retinoblastoma.

Antoneli CB, Ribeiro Kde C, Sakamoto LH, Chojniak MM, Novaes PE, Arias VE
Pediatr Blood Cancer 2007 Mar;48(3):306-10. doi: 10.1002/pbc.20793. PMID: 16572402

Obstructive jaundice as a presentation of ganglioneuroblastoma.

Ito A, Uno T, Gunji Y, Yamauchi T, Egami S, Kawarasaki H, Momoi MY
J Pediatr Hematol Oncol 2005 Feb;27(2):112-4. doi: 10.1097/01.mph.0000153445.20945.fd. PMID: 15701990

See all (16)

Prognosis

A Metastatic Neuroblastic Tumor in a 28-Month-old Boy: Unusual Spontaneous Regression From Neuroblastoma to Ganglioneuroma?

Yamada A, Kinoshita M, Kamimura S, Nakame K, Moritake H
J Pediatr Hematol Oncol 2022 Mar 1;44(2):e589-e592. doi: 10.1097/MPH.0000000000002226. PMID: 34054050

Incidence of Horner syndrome associated with neuroblastic disease.

Clinicopathological features of neuroblastic tumors with opsoclonus-myoclonus-ataxia syndrome: Follicular structure predicts a better neurological outcome.

Fukushima H, Inoue T, Takama Y, Ishii N, Okuno T, Kobayashi Y, Yoneda A, Nakamura T, Kuki I, Hara J
Pathol Int 2017 Oct;67(10):503-509. doi: 10.1111/pin.12591. PMID: 28971571

Prognostic importance of cyclin E1 expression in neuroblastic tumors in children.

Taran K, Owecka A, Kobos J
Pol J Pathol 2013 Jun;64(2):149-52. doi: 10.5114/pjp.2013.36016. PMID: 23900874

Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation.

Kopelman JE, McLean IW, Rosenberg SH
Ophthalmology 1987 Apr;94(4):371-7. doi: 10.1016/s0161-6420(87)33436-0. PMID: 3587919

See all (54)

Clinical prediction guides

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Peripheral neck nerve tumor: A 73-case study and literature review.

Boumaza K, Michel G, Salaud C, Bossard C, Espitalier F, Malard O
Eur Ann Otorhinolaryngol Head Neck Dis 2019 Nov;136(6):455-460. Epub 2019 Sep 16 doi: 10.1016/j.anorl.2019.09.005. PMID: 31537489

Expression of Disialoganglioside (GD2) in Neuroblastic Tumors: A Prognostic Value for Patients Treated With Anti-GD2 Immunotherapy.

Retinoblastoma.

Melamud A, Palekar R, Singh A
Am Fam Physician 2006 Mar 15;73(6):1039-44. PMID: 16570739

Multivariate analysis of risk factors for metastasis in retinoblastoma treated by enucleation.

Kopelman JE, McLean IW, Rosenberg SH
Ophthalmology 1987 Apr;94(4):371-7. doi: 10.1016/s0161-6420(87)33436-0. PMID: 3587919

See all (35)

Recent systematic reviews

Incidence and Risk Factors for Chyle Leaks After Neuroblastic Tumor Resection: A Systematic Review of Published Studies.

Raitio A, Losty PD
J Pediatr Surg 2024 Aug;59(8):1611-1614. Epub 2024 Feb 26 doi: 10.1016/j.jpedsurg.2024.02.018. PMID: 38490882

Congenital malformation syndromes associated with peripheral neuroblastic tumors: A systematic review.

Sznewajs A, Pon E, Matthay KK
Pediatr Blood Cancer 2019 Oct;66(10):e27901. Epub 2019 Jul 2 doi: 10.1002/pbc.27901. PMID: 31264798

Retinoblastoma associated with chromosomal 13q14 deletion mosaicism.

Kivelä T, Tuppurainen K, Riikonen P, Vapalahti M
Ophthalmology 2003 Oct;110(10):1983-8. doi: 10.1016/S0161-6420(03)00484-6. PMID: 14522775

Trilateral retinoblastoma: a meta-analysis of hereditary retinoblastoma associated with primary ectopic intracranial retinoblastoma.

Kivelä T
J Clin Oncol 1999 Jun;17(6):1829-37. doi: 10.1200/JCO.1999.17.6.1829. PMID: 10561222

See all (4)

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Neuroblastic tumor

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

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Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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