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Sarcomatoid carcinoma

MedGen UID:
60009
Concept ID:
C0205697
Neoplastic Process
Synonyms: Carcinoma, Spindle Cell; Carcinoma, Spindle-Cell; Spindle-Cell Carcinoma; Spindle-Cell Carcinomas
SNOMED CT: Spindle cell carcinoma (65692009); Sarcomatoid carcinoma (23109009); Polypoid squamous cell carcinoma (65692009); Pseudosarcomatous carcinoma (23109009)
 
Monarch Initiative: MONDO:0006406

Definition

A malignant epithelial neoplasm characterized by the presence of spindle cells and anaplastic morphologic features. Giant cells and a sarcomatous component may also be present. [from NCI]

Professional guidelines

PubMed

Vlachou E, Johnson BA 3rd, Baraban E, Nadal R, Hoffman-Censits J
Am Soc Clin Oncol Educ Book 2024 Jun;44(3):e438640. doi: 10.1200/EDBK_438640. PMID: 38870453
Gong T, Jia B, Chen C, Zhang Z, Wang C
J Int Med Res 2022 Oct;50(10):3000605221128092. doi: 10.1177/03000605221128092. PMID: 36224744Free PMC Article
Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738

Recent clinical studies

Etiology

Ma Y, Li W, Li Z, Chen J, Wang H, Jiang T, Zhu J
Front Immunol 2022;13:976739. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.976739. PMID: 36341325Free PMC Article
Hornick JL
Ann Diagn Pathol 2018 Dec;37:118-124. Epub 2018 Oct 11 doi: 10.1016/j.anndiagpath.2018.10.006. PMID: 30340082
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

Diagnosis

Yoshida KI, Yoshida A
Surg Pathol Clin 2024 Jun;17(2):243-255. Epub 2023 Dec 15 doi: 10.1016/j.path.2023.11.008. PMID: 38692808
Papke DJ Jr
Surg Pathol Clin 2023 Sep;16(3):609-634. Epub 2023 Jun 11 doi: 10.1016/j.path.2023.04.013. PMID: 37536892
Lu S, Fang J, Li X, Cao L, Zhou J, Guo Q, Liang Z, Cheng Y, Jiang L, Yang N, Han Z, Shi J, Chen Y, Xu H, Zhang H, Chen G, Ma R, Sun S, Fan Y, Li J, Luo X, Wang L, Ren Y, Su W
Lancet Respir Med 2021 Oct;9(10):1154-1164. Epub 2021 Jun 21 doi: 10.1016/S2213-2600(21)00084-9. PMID: 34166627
McKenney JK
Mod Pathol 2018 Jan;31(S1):S133-142. doi: 10.1038/modpathol.2017.155. PMID: 29297486
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765

Therapy

Kwon HJ, Lee S, Han YB, Lee J, Kwon S, Kim H, Chung JH
Cancer Res Treat 2024 Apr;56(2):442-454. Epub 2023 Nov 14 doi: 10.4143/crt.2023.764. PMID: 37973906Free PMC Article
Zheng Y, Fu Y, Zhong Q, Deng R, Zhang Y
Future Oncol 2022 Feb;18(6):727-738. Epub 2021 Dec 9 doi: 10.2217/fon-2021-1071. PMID: 34879738
Markham A
Drugs 2021 Sep;81(14):1665-1670. doi: 10.1007/s40265-021-01584-0. PMID: 34455538
Lu S, Fang J, Li X, Cao L, Zhou J, Guo Q, Liang Z, Cheng Y, Jiang L, Yang N, Han Z, Shi J, Chen Y, Xu H, Zhang H, Chen G, Ma R, Sun S, Fan Y, Li J, Luo X, Wang L, Ren Y, Su W
Lancet Respir Med 2021 Oct;9(10):1154-1164. Epub 2021 Jun 21 doi: 10.1016/S2213-2600(21)00084-9. PMID: 34166627
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715

Prognosis

Krušlin B, Škara L, Vodopić T, Vrhovec B, Murgić J, Štimac G, Fröbe A, Lež C, Ulamec M, Gall-Trošelj K
Acta Med Acad 2021 Apr;50(1):71-87. doi: 10.5644/ama2006-124.327. PMID: 34075765
Delahunt B, Cheville JC, Martignoni G, Humphrey PA, Magi-Galluzzi C, McKenney J, Egevad L, Algaba F, Moch H, Grignon DJ, Montironi R, Srigley JR; Members of the ISUP Renal Tumor Panel
Am J Surg Pathol 2013 Oct;37(10):1490-504. doi: 10.1097/PAS.0b013e318299f0fb. PMID: 24025520
Raza MA, Mazzara PF
Arch Pathol Lab Med 2011 Jul;135(7):945-8. doi: 10.5858/2010-0074-RSR.1. PMID: 21732788
Litzky LA
Arch Pathol Lab Med 2008 Jul;132(7):1104-17. doi: 10.5858/2008-132-1104-PST. PMID: 18605765
Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

Clinical prediction guides

Wu W, Zheng L, Li F, Chen H, Huang C, Chen Q, Lin Y, Xu X, Dai Y
BMJ Open 2023 Oct 17;13(10):e072260. doi: 10.1136/bmjopen-2023-072260. PMID: 37848302Free PMC Article
Ma Y, Li W, Li Z, Chen J, Wang H, Jiang T, Zhu J
Front Immunol 2022;13:976739. Epub 2022 Oct 20 doi: 10.3389/fimmu.2022.976739. PMID: 36341325Free PMC Article
Malla M, Wang JF, Trepeta R, Feng A, Wang J
Clin Genitourin Cancer 2016 Oct;14(5):366-372. Epub 2016 Mar 10 doi: 10.1016/j.clgc.2016.03.004. PMID: 27050715
Mikuz G
Anal Quant Cytopathol Histpathol 2015 Feb;37(1):39-47. PMID: 26072633
Bostwick DG
Am J Clin Pathol 1994 Oct;102(4 Suppl 1):S38-56. PMID: 7524306

Recent systematic reviews

Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Zombori-Tóth N, Kiss S, Oštarijaš E, Alizadeh H, Zombori T
Surg Oncol 2022 Sep;44:101824. Epub 2022 Jul 31 doi: 10.1016/j.suronc.2022.101824. PMID: 35952403
Huey RW, Makawita S, Xiao L, Matamoros A, Estrella JS, Overman MJ, Varadhachary GR, Raghav K
BMC Cancer 2019 Oct 17;19(1):965. doi: 10.1186/s12885-019-6155-6. PMID: 31623602Free PMC Article
Schizas D, Mastoraki A, Bagias G, Ioannidi M, Kanavidis P, Moris D, Tsilimigras DI, Spartalis E, Arkadopoulos N, Liakakos T
J BUON 2018 Sep-Oct;23(5):1432-1438. PMID: 30570870
Stamatiou K, Galariotis N, Olympitis M, Papadopoulos P, Moschouris H, Lambrakopoulos A
G Chir 2011 Jan-Feb;32(1-2):23-8. PMID: 21352703

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