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Mixed germ cell tumor

MedGen UID:
87257
Concept ID:
C0334524
Neoplastic Process
Synonyms: Combined Germ Cell Neoplasm; combined germ cell neoplasm; Combined Germ Cell Tumor; combined germ cell tumor; combined germ cell tumour; mixed germ cell cancer; Mixed Germ Cell Neoplasm; mixed germ cell neoplasm; Mixed Germ Cell Tumor; mixed germ cell tumor
SNOMED CT: Mixed germ cell tumor (1156452003); Mixed germ cell tumor (32844007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015864
Orphanet: ORPHA180234

Definition

A rare germ cell tumor characterized by composition of two or more malignant germ cell components, the most common combination being dysgerminoma and yolk sac tumor. The tumors typically occur between childhood and young adulthood. They are usually located in the gonads, occasionally also in other regions. Clinical presentation corresponds to the individual germ cell components and the tumor location; manifestations may include abdominal pain, abdominal mass, and menstrual disorder in females, and a testicular mass in males. The most important prognostic factor is tumor stage. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed germ cell tumor
Follow this link to review classifications for Mixed germ cell tumor in Orphanet.

Professional guidelines

PubMed

Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
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Recent clinical studies

Etiology

Cano Garcia C, Panunzio A, Tappero S, Piccinelli ML, Barletta F, Incesu RB, Law KW, Scheipner L, Tian Z, Saad F, Shariat SF, Tilki D, Briganti A, De Cobelli O, Terrone C, Antonelli A, Banek S, Kluth LA, Chun FKH, Karakiewicz PI
Medicina (Kaunas) 2023 Feb 24;59(3) doi: 10.3390/medicina59030451. PMID: 36984452Free PMC Article
Wong JC, Bressler B, Salh B, Yoshida EM, Chatur N
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Diagnosis

Ma Y, Zhang W, Qiao Z, Yang T
Rev Esp Enferm Dig 2021 Feb;113(2):143-144. doi: 10.17235/reed.2020.7305/2020. PMID: 33222481
Wong JC, Bressler B, Salh B, Yoshida EM, Chatur N
J Crohns Colitis 2011 Apr;5(2):162-4. Epub 2010 Dec 13 doi: 10.1016/j.crohns.2010.11.002. PMID: 21453887
Shariat SF, Duchene D, Kabbani W, Mucher Z, Lotan Y
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Kao HW, Wu CJ, Chen CY, Sun GH, Lee SS, Peng YJ
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J Pediatr Hematol Oncol 2003 Apr;25(4):321-3. doi: 10.1097/00043426-200304000-00011. PMID: 12679648

Therapy

Has Simsek D, Civan C, Ekenel M, Kuyumcu S, Sanli Y
Clin Nucl Med 2021 May 1;46(5):415-418. doi: 10.1097/RLU.0000000000003563. PMID: 33630811
Schultz KA, Petronio J, Bendel A, Patterson R, Vaughn DJ
Pediatr Blood Cancer 2015 Jun;62(6):1072-4. Epub 2014 Nov 21 doi: 10.1002/pbc.25338. PMID: 25417786
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
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Indian J Gastroenterol 2004 Nov-Dec;23(6):223-4. PMID: 15627667
Ben Arush MW, Roguin A, Zamir E, el-Hassid R, Pries D, Gaitini D, Dale A, Postovsky S
Pediatr Hematol Oncol 1997 Jul-Aug;14(4):381-6. doi: 10.3109/08880019709041598. PMID: 9211543

Prognosis

Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Shariat SF, Duchene D, Kabbani W, Mucher Z, Lotan Y
Urology 2005 Dec;66(6):1319. doi: 10.1016/j.urology.2005.06.102. PMID: 16360470
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Burkons DM, Hart WR
Obstet Gynecol 1978 Feb;51(2):221-4. PMID: 622236

Clinical prediction guides

Sekar MD, Pradeep I, Srinivas BH, Kayal S
Int J Surg Pathol 2024 Aug;32(5):865-874. Epub 2023 Oct 19 doi: 10.1177/10668969231201413. PMID: 37853749
Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Sensu S, Keser SH, Gurbuz Y, Barisik NO, Gul AE
Arch Iran Med 2021 Apr 1;24(4):301-305. doi: 10.34172/aim.2021.42. PMID: 34196190
Lee YL, Lai CR, Yen MS
J Ovarian Res 2019 Jan 10;12(1):2. doi: 10.1186/s13048-018-0476-y. PMID: 30630520Free PMC Article
Cho DY, Wang YC, Ho WL
Childs Nerv Syst 1997 Jan;13(1):42-6. doi: 10.1007/s003810050038. PMID: 9083701

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