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Mixed germ cell tumor

MedGen UID:
87257
Concept ID:
C0334524
Neoplastic Process
Synonyms: Combined Germ Cell Neoplasm; combined germ cell neoplasm; Combined Germ Cell Tumor; combined germ cell tumor; combined germ cell tumour; mixed germ cell cancer; Mixed Germ Cell Neoplasm; mixed germ cell neoplasm; Mixed Germ Cell Tumor; mixed germ cell tumor
SNOMED CT: Mixed germ cell tumor (1156452003); Mixed germ cell tumor (32844007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0015864
Orphanet: ORPHA180234

Definition

A rare germ cell tumor characterized by composition of two or more malignant germ cell components, the most common combination being dysgerminoma and yolk sac tumor. The tumors typically occur between childhood and young adulthood. They are usually located in the gonads, occasionally also in other regions. Clinical presentation corresponds to the individual germ cell components and the tumor location; manifestations may include abdominal pain, abdominal mass, and menstrual disorder in females, and a testicular mass in males. The most important prognostic factor is tumor stage. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed germ cell tumor
Follow this link to review classifications for Mixed germ cell tumor in Orphanet.

Professional guidelines

PubMed

Liu P, Li W, Song HC, Jiao LL, Zhang WP, Sun N
J Pediatr Urol 2018 Oct;14(5):443.e1-443.e7. Epub 2018 Apr 3 doi: 10.1016/j.jpurol.2018.02.030. PMID: 29705139
Bhatti AB, Ahmed I, Ghauri RK, Saeed Q, Mir K
Asian Pac J Cancer Prev 2014;15(1):277-80. doi: 10.7314/apjcp.2014.15.1.277. PMID: 24528039
Zhang R, Sun YC, Zhang GY, Wu LY, Zuo J
Eur J Gynaecol Oncol 2012;33(5):489-92. PMID: 23185794

Recent clinical studies

Etiology

Philips MR, Menon AR, Kumar GR, Malik K, Chandrasekaran S, Ramaswamy T, Narayanaswamy K, Raja A
Urol Oncol 2023 May;41(5):258.e1-258.e6. Epub 2023 Apr 3 doi: 10.1016/j.urolonc.2023.02.008. PMID: 37019765
Uguz S, Yilmaz S, Guragac A, Topuz B, Aydur E
Clin Genitourin Cancer 2016 Feb;14(1):e55-7. Epub 2015 Oct 3 doi: 10.1016/j.clgc.2015.09.014. PMID: 26500052
Wiens AL, Hattab EM
J Neurosurg Pediatr 2014 Aug;14(2):129-35. Epub 2014 Jun 13 doi: 10.3171/2014.5.PEDS13526. PMID: 24926970
Ghaemmaghami F, Hasanzadeh M, Karimi Zarchi M, Fallahi A
Int J Surg 2008 Oct;6(5):382-6. Epub 2008 Jul 16 doi: 10.1016/j.ijsu.2008.07.002. PMID: 18715834
Whang CJ, Kwon Y
J Korean Med Sci 1995 Oct;10(5):379-87. doi: 10.3346/jkms.1995.10.5.379. PMID: 8750065Free PMC Article

Diagnosis

Philips MR, Menon AR, Kumar GR, Malik K, Chandrasekaran S, Ramaswamy T, Narayanaswamy K, Raja A
Urol Oncol 2023 May;41(5):258.e1-258.e6. Epub 2023 Apr 3 doi: 10.1016/j.urolonc.2023.02.008. PMID: 37019765
Gilligan T
J Clin Oncol 2016 Feb 1;34(4):303-6. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.0110. PMID: 26668343
Uguz S, Yilmaz S, Guragac A, Topuz B, Aydur E
Clin Genitourin Cancer 2016 Feb;14(1):e55-7. Epub 2015 Oct 3 doi: 10.1016/j.clgc.2015.09.014. PMID: 26500052
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Chuang KL, Liaw CC, Ueng SH, Liao SK, Pang ST, Chang YH, Chuang HC, Chuang CK
World J Surg Oncol 2010 Mar 23;8:21. doi: 10.1186/1477-7819-8-21. PMID: 20331874Free PMC Article

Therapy

Has Simsek D, Civan C, Ekenel M, Kuyumcu S, Sanli Y
Clin Nucl Med 2021 May 1;46(5):415-418. doi: 10.1097/RLU.0000000000003563. PMID: 33630811
Gilligan T
J Clin Oncol 2016 Feb 1;34(4):303-6. Epub 2015 Dec 14 doi: 10.1200/JCO.2015.64.0110. PMID: 26668343
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Kanter DJ, O'Brien MB, Shi XH, Chu T, Mishima T, Beriwal S, Epperly MW, Wipf P, Greenberger JS, Sadovsky Y
Placenta 2014 Feb;35(2):85-91. Epub 2014 Jan 2 doi: 10.1016/j.placenta.2013.12.011. PMID: 24418702Free PMC Article
Ghaemmaghami F, Hasanzadeh M, Karimi Zarchi M, Fallahi A
Int J Surg 2008 Oct;6(5):382-6. Epub 2008 Jul 16 doi: 10.1016/j.ijsu.2008.07.002. PMID: 18715834

Prognosis

Wiens AL, Hattab EM
J Neurosurg Pediatr 2014 Aug;14(2):129-35. Epub 2014 Jun 13 doi: 10.3171/2014.5.PEDS13526. PMID: 24926970
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Kojimahara T, Nakahara K, Takano T, Yaegashi N, Nishiyama H, Fujimori K, Sato N, Terada Y, Tase T, Yokoyama Y, Mizunuma H, Shoji T, Sugiyama T, Kurachi H
Tohoku J Exp Med 2013 Aug;230(4):211-7. doi: 10.1620/tjem.230.211. PMID: 23912096
Ghaemmaghami F, Hasanzadeh M, Karimi Zarchi M, Fallahi A
Int J Surg 2008 Oct;6(5):382-6. Epub 2008 Jul 16 doi: 10.1016/j.ijsu.2008.07.002. PMID: 18715834
Whang CJ, Kwon Y
J Korean Med Sci 1995 Oct;10(5):379-87. doi: 10.3346/jkms.1995.10.5.379. PMID: 8750065Free PMC Article

Clinical prediction guides

Trpchevska EN, Todorovska B, Todorovska MB, Trajkovska M, Nikolova D, Dzambaz D, Deriban G, Licoska-Josifovikj F
Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2023 Jul 1;44(2):47-52. Epub 2023 Jul 15 doi: 10.2478/prilozi-2023-0024. PMID: 37453124
Sensu S, Keser SH, Gurbuz Y, Barisik NO, Gul AE
Arch Iran Med 2021 Apr 1;24(4):301-305. doi: 10.34172/aim.2021.42. PMID: 34196190
Jiang XY, Lei S, Zhang L, Liu X, Lin MT, Blumcke I, Piao YS, Zhou D, Li JM
Acta Neuropathol Commun 2020 Aug 8;8(1):130. doi: 10.1186/s40478-020-00999-2. PMID: 32771066Free PMC Article
Kanter DJ, O'Brien MB, Shi XH, Chu T, Mishima T, Beriwal S, Epperly MW, Wipf P, Greenberger JS, Sadovsky Y
Placenta 2014 Feb;35(2):85-91. Epub 2014 Jan 2 doi: 10.1016/j.placenta.2013.12.011. PMID: 24418702Free PMC Article
Sigurdson AJ, Chang S, Annegers JF, Duphorne CM, Pillow PC, Amato RJ, Hutchinson LP, Sweeney AM, Strom SS
Nutr Cancer 1999;34(1):20-6. doi: 10.1207/S15327914NC340103. PMID: 10453437

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