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Mixed Carcinoma

MedGen UID:
1717421
•Concept ID:
C4264446
•
Neoplastic Process

Definition

A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Carcinoma

Professional guidelines

PubMed

Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment.
Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P
Endocr Relat Cancer 2007 Sep;14(3):549-67. doi: 10.1677/ERC-06-0060. PMID: 17914088
Histologic changes in small cell lung carcinoma after treatment.
Fushimi H, Kikui M, Morino H, Yamamoto S, Tateishi R, Wada A, Aozasa K, Kotoh K
Cancer 1996 Jan 15;77(2):278-83. doi: 10.1002/(SICI)1097-0142(19960115)77:2<278::AID-CNCR9>3.0.CO;2-I. PMID: 8625235
The role of surgery in the management of selected patients with small-cell carcinoma of the lung.
Baker RR, Ettinger DS, Ruckdeschel JD, Eggleston JC, McKneally MF, Abeloff MD, Woll J, Adelstein DJ
J Clin Oncol 1987 May;5(5):697-702. doi: 10.1200/JCO.1987.5.5.697. PMID: 3033160

Recent clinical studies

Etiology

Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma-a large-scale, multi-center, and retrospective study.
Yang X, Yin J, Fu Y, Shen Y, Zhang C, Yao S, Xu C, Xia M, Lou G, Liu J, Lin B, Wang J, Zhao W, Zhang J, Cheng W, Guo H, Guo R, Xue F, Wang X, Han L, Li X, Zhang P, Zhao J, Li W, Dou Y, Wang Z, Liu J, Li K, Chen G, Sun C, Sun P, Lu W, Yao Q
Diagn Pathol 2023 Jan 25;18(1):8. doi: 10.1186/s13000-023-01294-z. PMID: 36698195Free PMC Article
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
Park HK, Lee KY, Yoo MW, Hwang TS, Han HS
J Korean Med Sci 2016 Jun;31(6):866-72. Epub 2016 Apr 11 doi: 10.3346/jkms.2016.31.6.866. PMID: 27247494Free PMC Article

Diagnosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Preoperative and intraoperative assessment of myometrial invasion in patients with FIGO stage I non-endometrioid endometrial carcinoma-a large-scale, multi-center, and retrospective study.
Yang X, Yin J, Fu Y, Shen Y, Zhang C, Yao S, Xu C, Xia M, Lou G, Liu J, Lin B, Wang J, Zhao W, Zhang J, Cheng W, Guo H, Guo R, Xue F, Wang X, Han L, Li X, Zhang P, Zhao J, Li W, Dou Y, Wang Z, Liu J, Li K, Chen G, Sun C, Sun P, Lu W, Yao Q
Diagn Pathol 2023 Jan 25;18(1):8. doi: 10.1186/s13000-023-01294-z. PMID: 36698195Free PMC Article
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
Park HK, Lee KY, Yoo MW, Hwang TS, Han HS
J Korean Med Sci 2016 Jun;31(6):866-72. Epub 2016 Apr 11 doi: 10.3346/jkms.2016.31.6.866. PMID: 27247494Free PMC Article

Therapy

Evaluation of PARP and PDL-1 as potential therapeutic targets for women with high-grade neuroendocrine carcinomas of the cervix.
Carroll MR, Ramalingam P, Salvo G, Fujimoto J, Solis Soto LM, Phoolcharoen N, Hillman RT, Cardnell R, Byers L, Frumovitz M
Int J Gynecol Cancer 2020 Sep;30(9):1303-1307. Epub 2020 Jul 29 doi: 10.1136/ijgc-2020-001649. PMID: 32727929Free PMC Article
HER2 testing of gynecologic carcinosarcomas: tumor stratification for potential targeted therapy.
Rottmann D, Snir OL, Wu X, Wong S, Hui P, Santin AD, Buza N
Mod Pathol 2020 Jan;33(1):118-127. Epub 2019 Sep 2 doi: 10.1038/s41379-019-0358-x. PMID: 31477811
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Turbiner J, Moreno-Bueno G, Dahiya S, Sánchez-Estevez C, Hardisson D, Prat J, Oliva E, Palacios J
Mod Pathol 2008 Aug;21(8):925-36. Epub 2008 May 23 doi: 10.1038/modpathol.2008.49. PMID: 18500270
Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions.
Quattrocchi CC, Piciucchi S, Sammarra M, Santini D, Vincenzi B, Tonini G, Grasso RF, Zobel BB
Radiol Med 2007 Oct;112(7):1049-59. Epub 2007 Oct 21 doi: 10.1007/s11547-007-0205-x. PMID: 17952675
Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment.
Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P
Endocr Relat Cancer 2007 Sep;14(3):549-67. doi: 10.1677/ERC-06-0060. PMID: 17914088

Prognosis

Comparison of clinical characteristics and prognosis in endometrial carcinoma with different pathological types: a retrospective population-based study.
Zhang G, Nie F, Zhao W, Han P, Wen J, Cheng X, Wu W, Liu Q, Sun Y, Wang Y, Liu Y, Ren F
World J Surg Oncol 2023 Nov 21;21(1):357. doi: 10.1186/s12957-023-03241-0. PMID: 37986077Free PMC Article
Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Co-Expression of Mesothelin and CA125 Is Associated with the Poor Prognosis of Endometrial Serous Carcinoma and Mixed Carcinomas Including Serous Carcinoma.
Kakimoto S, Miyamoto M, Einama T, Matsuura H, Iwahashi H, Ishibashi H, Sakamoto T, Hada T, Takano M
Pathol Oncol Res 2020 Oct;26(4):2299-2306. Epub 2020 May 28 doi: 10.1007/s12253-020-00823-1. PMID: 32468249
Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
Park HK, Lee KY, Yoo MW, Hwang TS, Han HS
J Korean Med Sci 2016 Jun;31(6):866-72. Epub 2016 Apr 11 doi: 10.3346/jkms.2016.31.6.866. PMID: 27247494Free PMC Article
Pure compared with mixed serous endometrial carcinoma: two different entities?
Roelofsen T, van Ham MA, Wiersma van Tilburg JM, Zomer SF, Bol M, Massuger LF, Bulten J
Obstet Gynecol 2012 Dec;120(6):1371-81. doi: 10.1097/aog.0b013e318273732e. PMID: 23168762

Recent systematic reviews

Clinicopathological Features Associated with Microsatellite Instability/Mismatch Repair Deficiency in Uterine Carcinosarcoma: A Quantitative Systematic Review.
Travaglino A, Raffone A, Santoro A, Raimondo D, Orsini B, Casadio P, Zullo F, Seracchioli R, Zannoni GF, Insabato L, Mollo A
Pathobiology 2022;89(4):198-204. Epub 2022 Mar 1 doi: 10.1159/000521876. PMID: 35231921

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