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Mixed Carcinoma

MedGen UID:
1717421
•Concept ID:
C4264446
•
Neoplastic Process

Definition

A carcinoma characterized by the presence of more than one malignant epithelial histologic pattern. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Carcinoma

Professional guidelines

PubMed

Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment.
Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P
Endocr Relat Cancer 2007 Sep;14(3):549-67. doi: 10.1677/ERC-06-0060. PMID: 17914088
Histologic changes in small cell lung carcinoma after treatment.
Fushimi H, Kikui M, Morino H, Yamamoto S, Tateishi R, Wada A, Aozasa K, Kotoh K
Cancer 1996 Jan 15;77(2):278-83. doi: 10.1002/(SICI)1097-0142(19960115)77:2<278::AID-CNCR9>3.0.CO;2-I. PMID: 8625235
The role of surgery in the management of selected patients with small-cell carcinoma of the lung.
Baker RR, Ettinger DS, Ruckdeschel JD, Eggleston JC, McKneally MF, Abeloff MD, Woll J, Adelstein DJ
J Clin Oncol 1987 May;5(5):697-702. doi: 10.1200/JCO.1987.5.5.697. PMID: 3033160

Recent clinical studies

Therapy

HER2 testing of gynecologic carcinosarcomas: tumor stratification for potential targeted therapy.
Rottmann D, Snir OL, Wu X, Wong S, Hui P, Santin AD, Buza N
Mod Pathol 2020 Jan;33(1):118-127. Epub 2019 Sep 2 doi: 10.1038/s41379-019-0358-x. PMID: 31477811
A national study of kidney graft tumor treatments: Toward ablative therapy.
Guleryuz K, Doerfler A, Codas R, Coffin G, Hubert J, Lechevallier E, Tillou X; Renal Transplantation Committee of the French Urological Association (CTAFU)
Surgery 2016 Jul;160(1):237-244. Epub 2016 Mar 29 doi: 10.1016/j.surg.2016.01.022. PMID: 27032620
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Turbiner J, Moreno-Bueno G, Dahiya S, Sánchez-Estevez C, Hardisson D, Prat J, Oliva E, Palacios J
Mod Pathol 2008 Aug;21(8):925-36. Epub 2008 May 23 doi: 10.1038/modpathol.2008.49. PMID: 18500270
Bone metastases in breast cancer: higher prevalence of osteosclerotic lesions.
Quattrocchi CC, Piciucchi S, Sammarra M, Santini D, Vincenzi B, Tonini G, Grasso RF, Zobel BB
Radiol Med 2007 Oct;112(7):1049-59. Epub 2007 Oct 21 doi: 10.1007/s11547-007-0205-x. PMID: 17952675
Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment.
Biglia N, Mariani L, Sgro L, Mininanni P, Moggio G, Sismondi P
Endocr Relat Cancer 2007 Sep;14(3):549-67. doi: 10.1677/ERC-06-0060. PMID: 17914088

Prognosis

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Clinical features of neuroendocrine prostate cancer.
Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, Nanus DM, Tagawa ST, Ballman KV, Beltran H
Eur J Cancer 2019 Nov;121:7-18. Epub 2019 Sep 13 doi: 10.1016/j.ejca.2019.08.011. PMID: 31525487Free PMC Article
Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
Park HK, Lee KY, Yoo MW, Hwang TS, Han HS
J Korean Med Sci 2016 Jun;31(6):866-72. Epub 2016 Apr 11 doi: 10.3346/jkms.2016.31.6.866. PMID: 27247494Free PMC Article

Clinical prediction guides

Extrauterine Mesonephric-like Carcinoma: A Comprehensive Single Institution Study of 33 Cases.
Euscher ED, Marques-Piubelli ML, Ramalingam P, Wistuba I, Lawson BC, Frumovitz M, Malpica A
Am J Surg Pathol 2023 Jun 1;47(6):635-648. Epub 2023 Apr 6 doi: 10.1097/PAS.0000000000002039. PMID: 37026792
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Mixed Carcinoma as an Independent Prognostic Factor in Submucosal Invasive Gastric Carcinoma.
Park HK, Lee KY, Yoo MW, Hwang TS, Han HS
J Korean Med Sci 2016 Jun;31(6):866-72. Epub 2016 Apr 11 doi: 10.3346/jkms.2016.31.6.866. PMID: 27247494Free PMC Article
The significance of extracellular mucin in breast fine needle aspiration specimens.
Shield PW, Ribu DL, Cominos D
Cytopathology 2016 Jun;27(3):185-92. Epub 2015 Jun 24 doi: 10.1111/cyt.12257. PMID: 26104545
Toward decoding the principles of cancer metastasis circuits.
Lu M, Jolly MK, Onuchic J, Ben-Jacob E
Cancer Res 2014 Sep 1;74(17):4574-87. doi: 10.1158/0008-5472.CAN-13-3367. PMID: 25183783

Recent systematic reviews

Clinicopathological Features Associated with Microsatellite Instability/Mismatch Repair Deficiency in Uterine Carcinosarcoma: A Quantitative Systematic Review.
Travaglino A, Raffone A, Santoro A, Raimondo D, Orsini B, Casadio P, Zullo F, Seracchioli R, Zannoni GF, Insabato L, Mollo A
Pathobiology 2022;89(4):198-204. Epub 2022 Mar 1 doi: 10.1159/000521876. PMID: 35231921

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