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Malignant Skin Appendage Neoplasm

MedGen UID:: 87563
•Concept ID:: C0346770
•: Neoplastic Process

Synonyms:

Malignant Cutaneous Adnexal Neoplasm; Malignant Epidermal Appendage Neoplasm; Malignant Epidermal Appendage Tumor; Malignant Neoplasm of Epidermal Appendage; Malignant Neoplasm of the Epidermal Appendage; Malignant Skin Adnexal Neoplasm; Malignant Skin Adnexal Tumor; Malignant skin tumor with adnexal differentiation; Malignant tumor of epidermal appendage; Malignant Tumor of Epidermal Appendage; Malignant Tumor of the Epidermal Appendage

SNOMED CT:

Malignant skin tumor with adnexal differentiation (255093003); Malignant tumor of epidermal appendage (255093003)

Definition

A malignant neoplasm that arises from the skin appendages. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Skin Appendage Neoplasm

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant neoplastic disease
        Malignant neoplasm of skin
        Malignant Skin Appendage Neoplasm
        Malignant Hair Follicle Neoplasm
        Malignant Germinative Follicular Epithelium Neoplasm
        Skin pilomatrix carcinoma
        Malignant Outer Hair Sheath and Infundibulum Neoplasm
        Malignant Proliferating Pilar Tumor
        Trichilemmal Carcinoma
        Trichoblastic Carcinoma
        Trichoblastic Carcinosarcoma
        Sebaceous gland cancer
        Sebaceous gland carcinoma
        Extraocular Cutaneous Sebaceous Carcinoma
        Head and Neck Sebaceous Carcinoma
        Ocular sebaceous carcinoma
        Sebaceous breast carcinoma
        Skin appendage carcinoma
        Adnexal Adenocarcinoma, Not Otherwise Specified
        Adnexal Cribriform Carcinoma
        Adnexal Secretory Carcinoma
        Signet Ring Cell/Histiocytoid Carcinoma
        Sweat gland carcinoma
        Apocrine adenocarcinoma
        Cutaneous adenocystic carcinoma
        Cutaneous mucoepidermoid carcinoma
        Cylindrocarcinoma
        Eccrine carcinoma
        Endocrine Mucin-Producing Sweat Gland Carcinoma
        Hidradenocarcinoma
        Malignant spiradenoma
        Microcystic adnexal carcinoma
        Primary Cutaneous Mucinous Carcinoma
        Spiradenocylindrocarcinoma
        Sweat Gland Tubular Carcinoma
        Syringocystadenocarcinoma Papilliferum
        Vulvar Adenocarcinoma of Sweat Gland Origin
        Sweat gland cancer
        Apocrine sweat gland cancer
        Eccrine sweat gland cancer
        Malignant Mixed Tumor of the Skin
        Malignant Vulvar Sweat Gland Neoplasm

Professional guidelines

PubMed

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review.

Wagner K, Jassal K, Lee JC, Ban EJ, Cameron R, Serpell J
ANZ J Surg 2021 Oct;91(10):1996-2001. Epub 2021 Feb 1 doi: 10.1111/ans.16626. PMID: 33522696

Restorative oncodermatology: Diagnosis and management of dermatologic sequelae from cancer therapies.

Rossi AM, Hibler BP, Navarrete-Dechent C, Lacouture ME
J Am Acad Dermatol 2021 Sep;85(3):693-707. Epub 2020 Aug 8 doi: 10.1016/j.jaad.2020.08.005. PMID: 32781177 Free PMC Article

Periocular skin cancer: Diagnosis and management.

Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650

See all (33)

Recent clinical studies

Etiology

Immune checkpoint inhibitor-related dermatologic adverse events.

Geisler AN, Phillips GS, Barrios DM, Wu J, Leung DYM, Moy AP, Kern JA, Lacouture ME
J Am Acad Dermatol 2020 Nov;83(5):1255-1268. Epub 2020 May 23 doi: 10.1016/j.jaad.2020.03.132. PMID: 32454097 Free PMC Article

Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.

Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401

Cutaneous T-cell Lymphoma.

Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499 Free PMC Article

Malignant Melanoma: Beyond the Basics.

Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Nonmelanoma skin cancer.

Dubas LE, Ingraffea A
Facial Plast Surg Clin North Am 2013 Feb;21(1):43-53. doi: 10.1016/j.fsc.2012.10.003. PMID: 23369588

See all (214)

Diagnosis

Hidradenocarcinoma.

de Lima AA, Santos M, de Morais PM, Rodrigues CAC
An Bras Dermatol 2021 Mar-Apr;96(2):251-253. Epub 2021 Feb 5 doi: 10.1016/j.abd.2020.03.023. PMID: 33597101 Free PMC Article

Periocular skin cancer: Diagnosis and management.

Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650

Skin Adnexal Tumors in Plain Language: A Practical Approach for the General Surgical Pathologist.

Fulton EH, Kaley JR, Gardner JM
Arch Pathol Lab Med 2019 Jul;143(7):832-851. Epub 2019 Jan 14 doi: 10.5858/arpa.2018-0189-RA. PMID: 30638401

Cutaneous T-cell Lymphoma.

Pulitzer M
Clin Lab Med 2017 Sep;37(3):527-546. doi: 10.1016/j.cll.2017.06.006. PMID: 28802499 Free PMC Article

Malignant Melanoma: Beyond the Basics.

Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

See all (524)

Therapy

Management of Dermatologic Events Associated With the Nectin-4-directed Antibody-Drug Conjugate Enfortumab Vedotin.

Lacouture ME, Patel AB, Rosenberg JE, O'Donnell PH
Oncologist 2022 Mar 11;27(3):e223-e232. doi: 10.1093/oncolo/oyac001. PMID: 35274723 Free PMC Article

Periocular skin cancer: Diagnosis and management.

Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650

Immune checkpoint inhibitor-related dermatologic adverse events.

Keratocystoma of the parotid gland.

Komatsu H, Kumoi K, Inokuchi G, Hashimoto K, Nagao T, Otsuki N, Nibu KI
Auris Nasus Larynx 2020 Jun;47(3):481-484. Epub 2019 Jun 21 doi: 10.1016/j.anl.2019.05.006. PMID: 31230813

Dermatologic infections in cancer patients.

Gandhi M, Brieva JC, Lacouture ME
Cancer Treat Res 2014;161:299-317. doi: 10.1007/978-3-319-04220-6_10. PMID: 24706229

See all (90)

Prognosis

Esophageal lichen planus: Current knowledge, challenges and future perspectives.

Decker A, Schauer F, Lazaro A, Monasterio C, Schmidt AR, Schmitt-Graeff A, Kreisel W
World J Gastroenterol 2022 Nov 7;28(41):5893-5909. doi: 10.3748/wjg.v28.i41.5893. PMID: 36405107 Free PMC Article

Current Treatment Options for Cutaneous Adnexal Malignancies.

Goto H
Curr Treat Options Oncol 2022 May;23(5):736-748. Epub 2022 Mar 26 doi: 10.1007/s11864-022-00971-3. PMID: 35347560

Periocular skin cancer: Diagnosis and management.

Moran JM, Phelps PO
Dis Mon 2020 Oct;66(10):101046. Epub 2020 Jun 27 doi: 10.1016/j.disamonth.2020.101046. PMID: 32600650

Vulvar cancer: a review for dermatologists.

Chokoeva AA, Tchernev G, Castelli E, Orlando E, Verma SB, Grebe M, Wollina U
Wien Med Wochenschr 2015 Apr;165(7-8):164-77. Epub 2015 May 1 doi: 10.1007/s10354-015-0354-9. PMID: 25930015

Mammary and extramammary Paget's disease.

Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993 Free PMC Article

See all (192)

Clinical prediction guides

Recent developments in dermoscopy for dermatology.

Chen X, Lu Q, Chen C, Jiang G
J Cosmet Dermatol 2021 Jun;20(6):1611-1617. Epub 2020 Nov 28 doi: 10.1111/jocd.13846. PMID: 33197276

Dermoscopy of genital diseases: a review.

Lacarrubba F, Borghi A, Verzì AE, Corazza M, Stinco G, Micali G
J Eur Acad Dermatol Venereol 2020 Oct;34(10):2198-2207. Epub 2020 Jul 13 doi: 10.1111/jdv.16723. PMID: 32531092

Keratocystoma of the parotid gland.

Komatsu H, Kumoi K, Inokuchi G, Hashimoto K, Nagao T, Otsuki N, Nibu KI
Auris Nasus Larynx 2020 Jun;47(3):481-484. Epub 2019 Jun 21 doi: 10.1016/j.anl.2019.05.006. PMID: 31230813

High frequency ultrasound with color Doppler in dermatology.

Barcaui Ede O, Carvalho AC, Lopes FP, Piñeiro-Maceira J, Barcaui CB
An Bras Dermatol 2016 May-Jun;91(3):262-73. doi: 10.1590/abd1806-4841.20164446. PMID: 27438191 Free PMC Article

Sebaceous carcinoma.

Salm R, Wright GE
Beitr Pathol 1975 Jul;155(3):221-36. doi: 10.1016/s0005-8165(75)80118-1. PMID: 1180803

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Recent systematic reviews

A Systematic Review of the Epidemiology, Clinical Characteristics, Treatment, and Outcomes for Desmoplastic Trichoepithelioma: Underscoring Mohs Micrographic Surgery in Management.

Nanda R, Srivastava D, Nijhawan RI
Dermatol Surg 2024 Aug 1;50(8):695-698. Epub 2024 Apr 9 doi: 10.1097/DSS.0000000000004194. PMID: 38595132

Epidemiology, clinical characteristics, treatment, and outcomes of proliferating pilar tumors: A systematic review.

Nemeh MN, Curtiss P, Nijhawan RI
J Am Acad Dermatol 2024 Jan;90(1):122-124. Epub 2023 Jun 24 doi: 10.1016/j.jaad.2023.05.097. PMID: 37364614

Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review.

Osto M, Parry N, Rehman R, Ahmed U, Mehregan D
Am J Dermatopathol 2021 Dec 1;43(12):851-866. doi: 10.1097/DAD.0000000000001991. PMID: 34797787

Management of multiple trichoepithelioma: A review of pharmacological therapies.

Lobo Y, Blake T, Wheller L
Australas J Dermatol 2021 May;62(2):e192-e200. Epub 2021 Jan 5 doi: 10.1111/ajd.13537. PMID: 33403677

See all (4)

MedGen

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Malignant Skin Appendage Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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