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Ocular motility disease

MedGen UID:
14457
Concept ID:
C0028850
Disease or Syndrome
Synonyms: Eye Motility Disorder; Eye Motility Disorders; Eye Movement Disorder; Eye Movement Disorders; Ocular Motility Disorder; Ocular Motility Disorders
SNOMED CT: Disorder of eye movements (45030009)
 
Monarch Initiative: MONDO:0001584

Definition

Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Ocular motility disease

Professional guidelines

PubMed

Rossor T, Yeh EA, Khakoo Y, Angelini P, Hemingway C, Irani SR, Schleiermacher G, Santosh P, Lotze T, Dale RC, Deiva K, Hero B, Klein A, de Alarcon P, Gorman MP, Mitchell WG, Lim M; OMS Study Group
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Samanta D
Pediatr Neurol 2020 Feb;103:12-20. Epub 2019 Nov 1 doi: 10.1016/j.pediatrneurol.2019.10.003. PMID: 31836335

Recent clinical studies

Etiology

Hertle RW
J Binocul Vis Ocul Motil 2022 Jul-Sep;72(3):113-130. Epub 2022 May 17 PMID: 35579534
Macher S, Milenkovic I, Zrzavy T, Höftberger R, Seidel S, Berger-Sieczkowski E, Berger T, Rommer PS, Wiest G
Front Immunol 2021;12:753856. Epub 2021 Sep 30 doi: 10.3389/fimmu.2021.753856. PMID: 34659261Free PMC Article
Rosenberg ML
J Neuroophthalmol 2021 Dec 1;41(4):e688-e691. doi: 10.1097/WNO.0000000000001196. PMID: 34001741
Rosini F, Pretegiani E, Battisti C, Dotti MT, Federico A, Rufa A
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Diagnosis

Grossman SN, Rucker JC
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Semin Ophthalmol 2022 May 19;37(4):436-446. Epub 2021 Nov 14 doi: 10.1080/08820538.2021.2002371. PMID: 34779338
Rosenberg ML
J Neuroophthalmol 2021 Dec 1;41(4):e688-e691. doi: 10.1097/WNO.0000000000001196. PMID: 34001741
Manley DR, Alvi RA
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Therapy

Mukhija R, Agarwal D, Pujari A, Bajaj MS
BMJ Case Rep 2018 Jun 8;2018 doi: 10.1136/bcr-2017-224028. PMID: 29884714Free PMC Article
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Prognosis

Rizzo JR, Beheshti M, Dai W, Rucker JC
Semin Neurol 2019 Dec;39(6):775-784. Epub 2019 Dec 17 doi: 10.1055/s-0039-1698742. PMID: 31847048
Nerrant E, Tilikete C
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Gottlob I
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Schworm HD, Rudolph G
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Wilson ME, Eustis HS Jr, Parks MM
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Clinical prediction guides

Youn CE, Lu C, Cauchi J, MacGowan D, Morgenstern R, Scelsa S
J Neuromuscul Dis 2023;10(3):405-410. doi: 10.3233/JND-221579. PMID: 36872786
Lee SH, Kim JM, Kim JS
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Sheehy CK, Beaudry-Richard A, Bensinger E, Theis J, Green AJ
J Neuroophthalmol 2018 Dec;38(4):488-493. doi: 10.1097/WNO.0000000000000734. PMID: 30418331
Lee SH, Kim HJ, Kim JS
J Neuroophthalmol 2018 Sep;38(3):393-412. doi: 10.1097/WNO.0000000000000583. PMID: 29099407
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Recent systematic reviews

Graham L, Das J, Vitorio R, McDonald C, Walker R, Godfrey A, Morris R, Stuart S
Exp Brain Res 2023 Sep;241(9):2191-2203. Epub 2023 Aug 26 doi: 10.1007/s00221-023-06691-w. PMID: 37632535Free PMC Article
Opwonya J, Doan DNT, Kim SG, Kim JI, Ku B, Kim S, Park S, Kim JU
Neuropsychol Rev 2022 Jun;32(2):193-227. Epub 2021 May 6 doi: 10.1007/s11065-021-09495-3. PMID: 33959887Free PMC Article
Celdrán-Vivancos D, Noval-Martín S, González-Manrique M, Negoita A, Porto-Castro S
Arch Soc Esp Oftalmol (Engl Ed) 2021 Jul;96(7):366-376. Epub 2021 Feb 27 doi: 10.1016/j.oftale.2020.09.018. PMID: 34217474
Mahajan D, Votruba M
Acta Ophthalmol 2017 Dec;95(8):768-777. Epub 2017 Jun 9 doi: 10.1111/aos.13472. PMID: 29220126
Anderson DG, Walker RH, Connor M, Carr J, Margolis RL, Krause A
J Huntingtons Dis 2017;6(1):37-46. doi: 10.3233/JHD-160232. PMID: 28339400

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