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Disorder of pregnancy

MedGen UID:
56248
•Concept ID:
C0151864
•
Disease or Syndrome
Synonym: Pregnancy Disorder
SNOMED CT: Disorder of pregnancy (173300003)

Definition

A disorder that is related to pregnancy. Representative examples include ectopic pregnancy, toxemia of pregnancy, and gestational trophoblastic tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of pregnancy

Professional guidelines

PubMed

Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.
Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
Hypertensive Disorders of Pregnancy and Future Maternal Health: How Can the Evidence Guide Postpartum Management?
Hauspurg A, Countouris ME, Catov JM
Curr Hypertens Rep 2019 Nov 27;21(12):96. doi: 10.1007/s11906-019-0999-7. PMID: 31776692Free PMC Article
Phosphodiesterase Inhibition in the Treatment of Preeclampsia: What Is New?
Larré AB, Sontag F, Pasin DM, Paludo N, do Amaral RR, da Costa BEP, Poli-de-Figueiredo CE
Curr Hypertens Rep 2018 Jul 26;20(10):83. doi: 10.1007/s11906-018-0883-x. PMID: 30051151

Recent clinical studies

Etiology

Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.
Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
Eclampsia in the 21st century.
Fishel Bartal M, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S1237-S1253. Epub 2020 Sep 24 doi: 10.1016/j.ajog.2020.09.037. PMID: 32980358
Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review.
Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S
J Am Coll Cardiol 2020 Oct 6;76(14):1690-1702. doi: 10.1016/j.jacc.2020.08.014. PMID: 33004135
Intrahepatic Cholestasis of Pregnancy.
Smith DD, Rood KM
Clin Obstet Gynecol 2020 Mar;63(1):134-151. doi: 10.1097/GRF.0000000000000495. PMID: 31764000
Maternal preeclampsia and neonatal outcomes.
Backes CH, Markham K, Moorehead P, Cordero L, Nankervis CA, Giannone PJ
J Pregnancy 2011;2011:214365. Epub 2011 Apr 4 doi: 10.1155/2011/214365. PMID: 21547086Free PMC Article

Diagnosis

Hypertensive disorders of pregnancy: definition, management, and out-of-office blood pressure measurement.
Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
Eclampsia in the 21st century.
Fishel Bartal M, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S1237-S1253. Epub 2020 Sep 24 doi: 10.1016/j.ajog.2020.09.037. PMID: 32980358
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Preeclampsia-Pathophysiology and Clinical Presentations: JACC State-of-the-Art Review.
Ives CW, Sinkey R, Rajapreyar I, Tita ATN, Oparil S
J Am Coll Cardiol 2020 Oct 6;76(14):1690-1702. doi: 10.1016/j.jacc.2020.08.014. PMID: 33004135
Intrahepatic Cholestasis of Pregnancy.
Smith DD, Rood KM
Clin Obstet Gynecol 2020 Mar;63(1):134-151. doi: 10.1097/GRF.0000000000000495. PMID: 31764000

Therapy

Eclampsia in the 21st century.
Fishel Bartal M, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S1237-S1253. Epub 2020 Sep 24 doi: 10.1016/j.ajog.2020.09.037. PMID: 32980358
Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Henderson JT, Vesco KK, Senger CA, Thomas RG, Redmond N
JAMA 2021 Sep 28;326(12):1192-1206. doi: 10.1001/jama.2021.8551. PMID: 34581730
Furosemide for Accelerated Recovery of Blood Pressure Postpartum in women with a hypertensive disorder of pregnancy: A Randomized Controlled Trial.
Lopes Perdigao J, Lewey J, Hirshberg A, Koelper N, Srinivas SK, Elovitz MA, Levine LD
Hypertension 2021 May 5;77(5):1517-1524. Epub 2021 Feb 8 doi: 10.1161/HYPERTENSIONAHA.120.16133. PMID: 33550824Free PMC Article
Preconception Blood Pressure and Its Change Into Early Pregnancy: Early Risk Factors for Preeclampsia and Gestational Hypertension.
Nobles CJ, Mendola P, Mumford SL, Silver RM, Kim K, Andriessen VC, Connell M, Sjaarda L, Perkins NJ, Schisterman EF
Hypertension 2020 Sep;76(3):922-929. Epub 2020 Aug 3 doi: 10.1161/HYPERTENSIONAHA.120.14875. PMID: 32755413Free PMC Article
Hypertensive Disorders of Pregnancy and Future Maternal Health: How Can the Evidence Guide Postpartum Management?
Hauspurg A, Countouris ME, Catov JM
Curr Hypertens Rep 2019 Nov 27;21(12):96. doi: 10.1007/s11906-019-0999-7. PMID: 31776692Free PMC Article

Prognosis

Screening for preeclampsia in twin pregnancies.
Francisco C, Gamito M, Reddy M, Rolnik DL
Best Pract Res Clin Obstet Gynaecol 2022 Nov;84:55-65. Epub 2022 Mar 31 doi: 10.1016/j.bpobgyn.2022.03.008. PMID: 35450774
Eclampsia in the 21st century.
Fishel Bartal M, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S1237-S1253. Epub 2020 Sep 24 doi: 10.1016/j.ajog.2020.09.037. PMID: 32980358
Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance.
Fishel Bartal M, Lindheimer MD, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S819-S834. Epub 2020 Sep 1 doi: 10.1016/j.ajog.2020.08.108. PMID: 32882208
Preeclampsia, of mice and women.
Sones JL, Davisson RL
Physiol Genomics 2016 Aug 1;48(8):565-72. Epub 2016 Jun 3 doi: 10.1152/physiolgenomics.00125.2015. PMID: 27260843Free PMC Article
Therapeutics and anaesthesia.
Magee LA, Lowe S, Douglas MJ, Kathirgamanathan A
Best Pract Res Clin Obstet Gynaecol 2011 Aug;25(4):477-90. Epub 2011 Apr 7 doi: 10.1016/j.bpobgyn.2011.01.009. PMID: 21478058

Clinical prediction guides

Maternal hypertensive disorder of pregnancy and mortality in offspring from birth to young adulthood: national population based cohort study.
Huang C, Wei K, Lee PMY, Qin G, Yu Y, Li J
BMJ 2022 Oct 19;379:e072157. doi: 10.1136/bmj-2022-072157. PMID: 36261141Free PMC Article
Screening for preeclampsia in twin pregnancies.
Francisco C, Gamito M, Reddy M, Rolnik DL
Best Pract Res Clin Obstet Gynaecol 2022 Nov;84:55-65. Epub 2022 Mar 31 doi: 10.1016/j.bpobgyn.2022.03.008. PMID: 35450774
Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia.
Pei J, Liu Z, Wang C, Chu N, Liu L, Tang Y, Liu H, Xiang Q, Cheng H, Li M, Gu W
Biomolecules 2022 Mar 9;12(3) doi: 10.3390/biom12030422. PMID: 35327614Free PMC Article
Eclampsia in the 21st century.
Fishel Bartal M, Sibai BM
Am J Obstet Gynecol 2022 Feb;226(2S):S1237-S1253. Epub 2020 Sep 24 doi: 10.1016/j.ajog.2020.09.037. PMID: 32980358
Preeclampsia, of mice and women.
Sones JL, Davisson RL
Physiol Genomics 2016 Aug 1;48(8):565-72. Epub 2016 Jun 3 doi: 10.1152/physiolgenomics.00125.2015. PMID: 27260843Free PMC Article

Recent systematic reviews

The Dietary Inflammatory Index as a predictor of pregnancy outcomes: Systematic review and meta-analysis.
de Freitas NPA, Carvalho TR, Gonçalves CCRA, da Silva PHA, de Melo Romão LG, Kwak-Kim J, Cavalcante MB
J Reprod Immunol 2022 Aug;152:103651. Epub 2022 Jun 3 doi: 10.1016/j.jri.2022.103651. PMID: 35696840
Aspirin Use to Prevent Preeclampsia and Related Morbidity and Mortality: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force.
Henderson JT, Vesco KK, Senger CA, Thomas RG, Redmond N
JAMA 2021 Sep 28;326(12):1192-1206. doi: 10.1001/jama.2021.8551. PMID: 34581730
Prevalence and determinants of hypertensive disorders of pregnancy in Ethiopia: A systematic review and meta-analysis.
Tesfa E, Nibret E, Gizaw ST, Zenebe Y, Mekonnen Z, Assefa S, Melese M, Fentahun N, Munshea A
PLoS One 2020;15(9):e0239048. Epub 2020 Sep 16 doi: 10.1371/journal.pone.0239048. PMID: 32936834Free PMC Article
Prediction of adverse maternal outcomes from pre-eclampsia and other hypertensive disorders of pregnancy: A systematic review.
Ukah UV, De Silva DA, Payne B, Magee LA, Hutcheon JA, Brown H, Ansermino JM, Lee T, von Dadelszen P
Pregnancy Hypertens 2018 Jan;11:115-123. Epub 2017 Nov 21 doi: 10.1016/j.preghy.2017.11.006. PMID: 29198742
Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: a systematic review.
Gui S, Jia J, Niu X, Bai Y, Zou H, Deng J, Zhou R
J Renin Angiotensin Aldosterone Syst 2014 Mar;15(1):88-96. Epub 2013 Feb 22 doi: 10.1177/1470320313475910. PMID: 23435582

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