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Thyroid tumor

MedGen UID:
21546
•Concept ID:
C0040136
•
Neoplastic Process
Synonym: Neoplasm of the thyroid gland
SNOMED CT: Neoplasm of thyroid gland (127018007); Thyroid tumor (127018007); Tumor of thyroid gland (127018007)
 
HPO: HP:0100031
Monarch Initiative: MONDO:0015074
Orphanet: ORPHA100087

Definition

A tumor (abnormal growth of tissue) of the thyroid gland. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid tumor

Professional guidelines

PubMed

Immunohistochemistry in the pathologic diagnosis and management of thyroid neoplasms.
Crescenzi A, Baloch Z
Front Endocrinol (Lausanne) 2023;14:1198099. Epub 2023 May 31 doi: 10.3389/fendo.2023.1198099. PMID: 37324272Free PMC Article
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Expert consensus workshop report: Guidelines for thermal ablation of thyroid tumors (2019 edition).
Xu D, Ge M, Yang A, Cheng R, Sun H, Wang H, Zhang J, Cheng Z, Wu Z, Wang Z, Zhai B, Che Y, Chen L, Chen L, Cheng W, Dong G, Duan P, Fan W, Fei J, Fu R, Gao M, Huang P, Jiang T, Kuang J, Li H, Li P, Li X, Li Z, Lu M, Luo Y, Qin H, Qin J, Tan Z, Tang L, Wang Z, Wang S, Wang X, Wu G, Xie X, Xu H, Yin D, Qiu X, Jichun Y, Yu J, Zhan W, Zhang F, Zhang J, Zheng R, Zheng X, Zheng Y, Zhu Y, Zou Y, Meng Z, Ye X, Li H, Li X, Lin Z, Wang L, Wang L, Yang C, Wang Y, Zhou L, Ou D, Wang J, Gao M, Xu H, Liang P, Teng G
J Cancer Res Ther 2020 Sep;16(5):960-966. doi: 10.4103/jcrt.JCRT_558_19. PMID: 33004735

Recent clinical studies

Etiology

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk.
Feng X, Wang F, Yang W, Zheng Y, Liu C, Huang L, Li L, Cheng H, Cai H, Li X, Chen X, Yang X
JAMA Netw Open 2022 Dec 1;5(12):e2246311. doi: 10.1001/jamanetworkopen.2022.46311. PMID: 36508215Free PMC Article
Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
Molecular Chaperones and Thyroid Cancer.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F
Int J Mol Sci 2021 Apr 18;22(8) doi: 10.3390/ijms22084196. PMID: 33919591Free PMC Article
The Thyroid Tumor Microenvironment: Potential Targets for Therapeutic Intervention and Prognostication.
MacDonald L, Jenkins J, Purvis G, Lee J, Franco AT
Horm Cancer 2020 Oct;11(5-6):205-217. Epub 2020 Jun 17 doi: 10.1007/s12672-020-00390-6. PMID: 32548798Free PMC Article

Diagnosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Genetics, Diagnosis, and Management of Hürthle Cell Thyroid Neoplasms.
McFadden DG, Sadow PM
Front Endocrinol (Lausanne) 2021;12:696386. Epub 2021 Jun 10 doi: 10.3389/fendo.2021.696386. PMID: 34177816Free PMC Article
Aspectos fundamentales del nódulo tiroideo y el cáncer bien diferenciado de tiroides para los médicos general y familiar.
Gallegos-Hernández JF
Gac Med Mex 2019;155(6):619-623. doi: 10.24875/GMM.19005072. PMID: 31787768
TERT promoter mutations in thyroid cancer.
Liu R, Xing M
Endocr Relat Cancer 2016 Mar;23(3):R143-55. Epub 2016 Jan 5 doi: 10.1530/ERC-15-0533. PMID: 26733501Free PMC Article

Therapy

Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
Genomic and Transcriptomic Correlates of Thyroid Carcinoma Evolution after BRAF Inhibitor Therapy.
Lee M, Untch BR, Xu B, Ghossein R, Han C, Kuo F, Valero C, Nadeem Z, Patel N, Makarov V, Dogan S, Wong RJ, Sherman EJ, Ho AL, Chan TA, Fagin JA, Morris LGT
Mol Cancer Res 2022 Jan;20(1):45-55. Epub 2021 Oct 11 doi: 10.1158/1541-7786.MCR-21-0442. PMID: 34635506Free PMC Article
Management of Pediatric Graves Disease: A Review.
Quintanilla-Dieck L, Khalatbari HK, Dinauer CA, Rastatter JC, Chelius DC Jr, Katowitz WR, Shindo ML, Parisi MT, Kazahaya K
JAMA Otolaryngol Head Neck Surg 2021 Dec 1;147(12):1110-1118. doi: 10.1001/jamaoto.2021.2715. PMID: 34647991
Novel targeted therapies and immunotherapy for advanced thyroid cancers.
Naoum GE, Morkos M, Kim B, Arafat W
Mol Cancer 2018 Feb 19;17(1):51. doi: 10.1186/s12943-018-0786-0. PMID: 29455653Free PMC Article
Thyroid tumor-initiating cells: increasing evidence and opportunities for anticancer therapy (review).
Gao YJ, Li B, Wu XY, Cui J, Han JK
Oncol Rep 2014 Mar;31(3):1035-42. Epub 2014 Jan 14 doi: 10.3892/or.2014.2978. PMID: 24424445Free PMC Article

Prognosis

The 2022 WHO classification of thyroid tumors: novel concepts in nomenclature and grading.
Christofer Juhlin C, Mete O, Baloch ZW
Endocr Relat Cancer 2023 Feb 1;30(2) Epub 2022 Dec 22 doi: 10.1530/ERC-22-0293. PMID: 36445235
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, Kang XF, Jia SH, Du N, Kang L, Xu XJ
Cell Death Dis 2021 Aug 17;12(9):799. doi: 10.1038/s41419-021-04081-0. PMID: 34404767Free PMC Article
Molecular Chaperones and Thyroid Cancer.
Paladino L, Vitale AM, Santonocito R, Pitruzzella A, Cipolla C, Graceffa G, Bucchieri F, Conway de Macario E, Macario AJL, Rappa F
Int J Mol Sci 2021 Apr 18;22(8) doi: 10.3390/ijms22084196. PMID: 33919591Free PMC Article
TERT promoter mutations in thyroid cancer.
Liu R, Xing M
Endocr Relat Cancer 2016 Mar;23(3):R143-55. Epub 2016 Jan 5 doi: 10.1530/ERC-15-0533. PMID: 26733501Free PMC Article

Clinical prediction guides

Association Between Genetic Risk, Adherence to Healthy Lifestyle Behavior, and Thyroid Cancer Risk.
Feng X, Wang F, Yang W, Zheng Y, Liu C, Huang L, Li L, Cheng H, Cai H, Li X, Chen X, Yang X
JAMA Netw Open 2022 Dec 1;5(12):e2246311. doi: 10.1001/jamanetworkopen.2022.46311. PMID: 36508215Free PMC Article
DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis.
Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z
Int J Biol Sci 2022;18(11):4372-4387. Epub 2022 Jul 4 doi: 10.7150/ijbs.72397. PMID: 35864964Free PMC Article
Appraising the Effect of Potential Risk Factors on Thyroid Cancer: A Mendelian Randomization Study.
Huang L, Feng X, Yang W, Li X, Zhang K, Feng S, Wang F, Yang X
J Clin Endocrinol Metab 2022 Jun 16;107(7):e2783-e2791. doi: 10.1210/clinem/dgac196. PMID: 35366326
Circular RNAs and thyroid cancer: Closed molecules, open possibilities.
Shifman BM, Platonova NM, Vasilyev EV, Abdulkhabirova FM, Kachko VA
Crit Rev Oncol Hematol 2022 May;173:103662. Epub 2022 Mar 25 doi: 10.1016/j.critrevonc.2022.103662. PMID: 35341987
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, Kang XF, Jia SH, Du N, Kang L, Xu XJ
Cell Death Dis 2021 Aug 17;12(9):799. doi: 10.1038/s41419-021-04081-0. PMID: 34404767Free PMC Article

Recent systematic reviews

Microbiota and Thyroid Disease: An Updated Systematic Review.
Stramazzo I, Capriello S, Filardo S, Centanni M, Virili C
Adv Exp Med Biol 2023;1370:125-144. doi: 10.1007/5584_2023_770. PMID: 36971966
Safety and efficacy of ultrasound-guided thermal ablation in treating T1aN0M0 and T1bN0M0 papillary thyroid carcinoma: A meta-analysis.
Wang MH, Liu X, Wang Q, Zhang HW
Front Endocrinol (Lausanne) 2022;13:952113. Epub 2022 Jul 27 doi: 10.3389/fendo.2022.952113. PMID: 35966062Free PMC Article
Outcome of patients with intrathyroidal thymic carcinoma: a pooled analysis.
Gurizzan C, Zamparini M, Volante M, Tovazzi V, Amoroso V, Consoli F, Petrelli F, Grisanti S, Bossi P, Berruti A
Endocr Relat Cancer 2021 Jul 5;28(8):593-604. doi: 10.1530/ERC-21-0123. PMID: 34105516
RAS Mutations, and RET/PTC and PAX8/PPAR-gamma Chromosomal Rearrangements Are Also Prevalent in Benign Thyroid Lesions: Implications Thereof and A Systematic Review.
Najafian A, Noureldine S, Azar F, Atallah C, Trinh G, Schneider EB, Tufano RP, Zeiger MA
Thyroid 2017 Jan;27(1):39-48. Epub 2016 Nov 16 doi: 10.1089/thy.2016.0348. PMID: 27750019
MicroRNA Expression and Association with Clinicopathologic Features in Papillary Thyroid Cancer: A Systematic Review.
Aragon Han P, Weng CH, Khawaja HT, Nagarajan N, Schneider EB, Umbricht CB, Witwer KW, Zeiger MA
Thyroid 2015 Dec;25(12):1322-9. Epub 2015 Oct 8 doi: 10.1089/thy.2015.0193. PMID: 26414548

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