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Delayed ability to walk

MedGen UID:
66034
Concept ID:
C0241726
Finding
Synonym: delayed walking
 
HPO: HP:0031936

Definition

A failure to achieve the ability to walk at an appropriate developmental stage. Most children learn to walk in a series of stages, and learn to walk short distances independently between 12 and 15 months. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Delayed ability to walk

Conditions with this feature

Professional guidelines

PubMed

Iff J, Carmichael C, McKee S, Sehinovych I, McNeill C, Tesi-Rocha C, Henricson E, Muntoni F, Kitchen H
Adv Ther 2024 Aug;41(8):3278-3298. Epub 2024 Jul 3 doi: 10.1007/s12325-024-02915-9. PMID: 38958840Free PMC Article
Saposnik G, Andhavarapu S, Sainz de la Maza S, Castillo-Triviño T, Borges M, Barón BP, Sotoca J, Alonso A, Caminero AB, Borrega L, Sánchez-Menoyo JL, Barrero-Hernández FJ, Calles C, Brieva L, Blasco MR, García-Soto JD, Del Campo-Amigo M, Navarro-Cantó L, Agüera E, Garcés M, Carmona O, Gabaldón-Torres L, Forero L, Hervás M, García-Arcelay E, Terzaghi M, Gómez-Ballesteros R, Maurino J
Mult Scler Relat Disord 2022 Dec;68:104138. Epub 2022 Aug 20 doi: 10.1016/j.msard.2022.104138. PMID: 36029707
Spittle AJ, Anderson PJ, Tapawan SJ, Doyle LW, Cheong JLY
Semin Fetal Neonatal Med 2021 Jun;26(3):101203. Epub 2021 Jan 29 doi: 10.1016/j.siny.2021.101203. PMID: 33547000

Recent clinical studies

Etiology

Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840Free PMC Article
Caballero-García A, Pascual-Fernández J, Noriega-González DC, Bello HJ, Pons-Biescas A, Roche E, Córdova-Martínez A
Nutrients 2021 Sep 8;13(9) doi: 10.3390/nu13093133. PMID: 34579009Free PMC Article
Winders P, Wolter-Warmerdam K, Hickey F
J Intellect Disabil Res 2019 Apr;63(4):346-356. Epub 2018 Dec 21 doi: 10.1111/jir.12580. PMID: 30575169
Cameron MH, Nilsagard Y
Handb Clin Neurol 2018;159:237-250. doi: 10.1016/B978-0-444-63916-5.00015-X. PMID: 30482317
Duncan PW, Sullivan KJ, Behrman AL, Azen SP, Wu SS, Nadeau SE, Dobkin BH, Rose DK, Tilson JK, Cen S, Hayden SK; LEAPS Investigative Team
N Engl J Med 2011 May 26;364(21):2026-36. doi: 10.1056/NEJMoa1010790. PMID: 21612471Free PMC Article

Diagnosis

Fairchild JK, Myers J, Louras P, Jo B, McNerney MW, Hallmayer J, Yesavage J
Am J Geriatr Psychiatry 2024 Apr;32(4):463-474. Epub 2023 Dec 11 doi: 10.1016/j.jagp.2023.12.002. PMID: 38220592
Pijnenburg L, Giannini M, Bouchard-Marmen M, Arnaud L, Barsotti S, Bellando-Randone S, Bernardi L, Bini P, Blagojevic J, Codullo V, Couderc M, De Moreuil C, Dernis E, Diamanti L, Dubost JJ, Duval F, Emmi G, Galempoix JM, Geny B, Gottenberg JE, Groza M, Guffroy A, Guichard I, Guilpain P, Hervier B, Hudson M, Iaccarino L, Iannone F, Lebrun D, Marchioni E, Mariampillai K, Maurier F, Mosca M, Nadaj-Pakleza A, Nannini C, Piot JM, Prieto-González S, Poursac N, Rouanet E, Sellam J, Selva-O'Callaghan A, Séverac F, Sibilia J, Sole G, Soulages A, Terrier B, Tournadre A, Troyanov Y, Vernier N, Vesperini V, Viallard JF, Ziane R, Cavagna L, Meyer A
RMD Open 2023 Sep;9(3) doi: 10.1136/rmdopen-2023-003081. PMID: 37666644Free PMC Article
Fumagalli F, Calbi V, Natali Sora MG, Sessa M, Baldoli C, Rancoita PMV, Ciotti F, Sarzana M, Fraschini M, Zambon AA, Acquati S, Redaelli D, Attanasio V, Miglietta S, De Mattia F, Barzaghi F, Ferrua F, Migliavacca M, Tucci F, Gallo V, Del Carro U, Canale S, Spiga I, Lorioli L, Recupero S, Fratini ES, Morena F, Silvani P, Calvi MR, Facchini M, Locatelli S, Corti A, Zancan S, Antonioli G, Farinelli G, Gabaldo M, Garcia-Segovia J, Schwab LC, Downey GF, Filippi M, Cicalese MP, Martino S, Di Serio C, Ciceri F, Bernardo ME, Naldini L, Biffi A, Aiuti A
Lancet 2022 Jan 22;399(10322):372-383. doi: 10.1016/S0140-6736(21)02017-1. PMID: 35065785Free PMC Article
Belsky DW, Caspi A, Arseneault L, Baccarelli A, Corcoran DL, Gao X, Hannon E, Harrington HL, Rasmussen LJ, Houts R, Huffman K, Kraus WE, Kwon D, Mill J, Pieper CF, Prinz JA, Poulton R, Schwartz J, Sugden K, Vokonas P, Williams BS, Moffitt TE
Elife 2020 May 5;9 doi: 10.7554/eLife.54870. PMID: 32367804Free PMC Article
Langhorne P, Collier JM, Bate PJ, Thuy MN, Bernhardt J
Cochrane Database Syst Rev 2018 Oct 16;10(10):CD006187. doi: 10.1002/14651858.CD006187.pub3. PMID: 30321906Free PMC Article

Therapy

Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840Free PMC Article
Caballero-García A, Pascual-Fernández J, Noriega-González DC, Bello HJ, Pons-Biescas A, Roche E, Córdova-Martínez A
Nutrients 2021 Sep 8;13(9) doi: 10.3390/nu13093133. PMID: 34579009Free PMC Article
Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators
JAMA 2014 Jun 18;311(23):2387-96. doi: 10.1001/jama.2014.5616. PMID: 24866862Free PMC Article
Mendell JR, Rodino-Klapac LR, Sahenk Z, Roush K, Bird L, Lowes LP, Alfano L, Gomez AM, Lewis S, Kota J, Malik V, Shontz K, Walker CM, Flanigan KM, Corridore M, Kean JR, Allen HD, Shilling C, Melia KR, Sazani P, Saoud JB, Kaye EM; Eteplirsen Study Group
Ann Neurol 2013 Nov;74(5):637-47. Epub 2013 Sep 10 doi: 10.1002/ana.23982. PMID: 23907995
Duncan PW, Sullivan KJ, Behrman AL, Azen SP, Wu SS, Nadeau SE, Dobkin BH, Rose DK, Tilson JK, Cen S, Hayden SK; LEAPS Investigative Team
N Engl J Med 2011 May 26;364(21):2026-36. doi: 10.1056/NEJMoa1010790. PMID: 21612471Free PMC Article

Prognosis

Nathan SD, Deng C, King CS, DuBrock HM, Elwing J, Rajagopal S, Rischard F, Sahay S, Broderick M, Shen E, Smith P, Tapson VF, Waxman AB
Chest 2023 Feb;163(2):398-406. Epub 2022 Sep 15 doi: 10.1016/j.chest.2022.09.007. PMID: 36115497Free PMC Article
Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840Free PMC Article
Fumagalli F, Calbi V, Natali Sora MG, Sessa M, Baldoli C, Rancoita PMV, Ciotti F, Sarzana M, Fraschini M, Zambon AA, Acquati S, Redaelli D, Attanasio V, Miglietta S, De Mattia F, Barzaghi F, Ferrua F, Migliavacca M, Tucci F, Gallo V, Del Carro U, Canale S, Spiga I, Lorioli L, Recupero S, Fratini ES, Morena F, Silvani P, Calvi MR, Facchini M, Locatelli S, Corti A, Zancan S, Antonioli G, Farinelli G, Gabaldo M, Garcia-Segovia J, Schwab LC, Downey GF, Filippi M, Cicalese MP, Martino S, Di Serio C, Ciceri F, Bernardo ME, Naldini L, Biffi A, Aiuti A
Lancet 2022 Jan 22;399(10322):372-383. doi: 10.1016/S0140-6736(21)02017-1. PMID: 35065785Free PMC Article
Cameron MH, Nilsagard Y
Handb Clin Neurol 2018;159:237-250. doi: 10.1016/B978-0-444-63916-5.00015-X. PMID: 30482317
Rossen J, Yngve A, Hagströmer M, Brismar K, Ainsworth BE, Iskull C, Möller P, Johansson UB
BMC Public Health 2015 Jul 12;15:647. doi: 10.1186/s12889-015-1941-9. PMID: 26164092Free PMC Article

Clinical prediction guides

Lublin FD, Häring DA, Ganjgahi H, Ocampo A, Hatami F, Čuklina J, Aarden P, Dahlke F, Arnold DL, Wiendl H, Chitnis T, Nichols TE, Kieseier BC, Bermel RA
Brain 2022 Sep 14;145(9):3147-3161. doi: 10.1093/brain/awac016. PMID: 35104840Free PMC Article
Fumagalli F, Calbi V, Natali Sora MG, Sessa M, Baldoli C, Rancoita PMV, Ciotti F, Sarzana M, Fraschini M, Zambon AA, Acquati S, Redaelli D, Attanasio V, Miglietta S, De Mattia F, Barzaghi F, Ferrua F, Migliavacca M, Tucci F, Gallo V, Del Carro U, Canale S, Spiga I, Lorioli L, Recupero S, Fratini ES, Morena F, Silvani P, Calvi MR, Facchini M, Locatelli S, Corti A, Zancan S, Antonioli G, Farinelli G, Gabaldo M, Garcia-Segovia J, Schwab LC, Downey GF, Filippi M, Cicalese MP, Martino S, Di Serio C, Ciceri F, Bernardo ME, Naldini L, Biffi A, Aiuti A
Lancet 2022 Jan 22;399(10322):372-383. doi: 10.1016/S0140-6736(21)02017-1. PMID: 35065785Free PMC Article
Winders P, Wolter-Warmerdam K, Hickey F
J Intellect Disabil Res 2019 Apr;63(4):346-356. Epub 2018 Dec 21 doi: 10.1111/jir.12580. PMID: 30575169
Malak R, Kostiukow A, Krawczyk-Wasielewska A, Mojs E, Samborski W
Med Sci Monit 2015 Jul 1;21:1904-10. doi: 10.12659/MSM.893377. PMID: 26132100Free PMC Article
Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators
JAMA 2014 Jun 18;311(23):2387-96. doi: 10.1001/jama.2014.5616. PMID: 24866862Free PMC Article

Recent systematic reviews

Lashkarbolouk N, Mazandarani M, Ilharreborde B, Nabian MH
BMC Pediatr 2023 Nov 18;23(1):578. doi: 10.1186/s12887-023-04395-2. PMID: 37980513Free PMC Article
Langhorne P, Collier JM, Bate PJ, Thuy MN, Bernhardt J
Cochrane Database Syst Rev 2018 Oct 16;10(10):CD006187. doi: 10.1002/14651858.CD006187.pub3. PMID: 30321906Free PMC Article
Hughes RA, Brassington R, Gunn AA, van Doorn PA
Cochrane Database Syst Rev 2016 Oct 24;10(10):CD001446. doi: 10.1002/14651858.CD001446.pub5. PMID: 27775812Free PMC Article
De Bellis UG, Legnani C, Calori GM
Injury 2014 Feb;45(2):356-61. Epub 2013 Sep 20 doi: 10.1016/j.injury.2013.09.018. PMID: 24112700
Hughes RA, van Doorn PA
Cochrane Database Syst Rev 2012 Aug 15;(8):CD001446. doi: 10.1002/14651858.CD001446.pub4. PMID: 22895921

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