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Throat Carcinoma

MedGen UID:
148145
•Concept ID:
C0740339
•
Neoplastic Process
Synonym: Throat Cancer

Definition

Carcinoma, predominantly squamous cell, arising from epithelial cells of the larynx or pharynx. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThroat Carcinoma

Professional guidelines

PubMed

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Management of locally recurrent nasopharyngeal carcinoma.
Lee AWM, Ng WT, Chan JYW, Corry J, Mäkitie A, Mendenhall WM, Rinaldo A, Rodrigo JP, Saba NF, Strojan P, Suárez C, Vermorken JB, Yom SS, Ferlito A
Cancer Treat Rev 2019 Sep;79:101890. Epub 2019 Aug 21 doi: 10.1016/j.ctrv.2019.101890. PMID: 31470314
Clinical Practice Guideline: Evaluation of the Neck Mass in Adults.
Pynnonen MA, Gillespie MB, Roman B, Rosenfeld RM, Tunkel DE, Bontempo L, Brook I, Chick DA, Colandrea M, Finestone SA, Fowler JC, Griffith CC, Henson Z, Levine C, Mehta V, Salama A, Scharpf J, Shatzkes DR, Stern WB, Youngerman JS, Corrigan MD
Otolaryngol Head Neck Surg 2017 Sep;157(2_suppl):S1-S30. doi: 10.1177/0194599817722550. PMID: 28891406

Recent clinical studies

Etiology

Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
YTHDF1-enhanced iron metabolism depends on TFRC m(6)A methylation.
Ye J, Wang Z, Chen X, Jiang X, Dong Z, Hu S, Li W, Liu Y, Liao B, Han W, Shen J, Xiao M
Theranostics 2020;10(26):12072-12089. Epub 2020 Oct 26 doi: 10.7150/thno.51231. PMID: 33204330Free PMC Article
Throat Microbial Community Structure and Functional Changes in Postsurgery Laryngeal Carcinoma Patients.
Hsueh CY, Gong H, Cong N, Sun J, Lau HC, Guo Y, Huang Q, Yuan X, Zhang M, Tao L, Zhou L
Appl Environ Microbiol 2020 Nov 24;86(24) doi: 10.1128/AEM.01849-20. PMID: 33008819Free PMC Article
Target volume selection and delineation (T and N) for primary radiation treatment of oral cavity, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinoma.
Grégoire V, Grau C, Lapeyre M, Maingon P
Oral Oncol 2018 Dec;87:131-137. Epub 2018 Nov 3 doi: 10.1016/j.oraloncology.2018.10.034. PMID: 30527228

Diagnosis

Primary nasopharyngeal tuberculosis.
Misirovs R, Johnston L, Green R
BMJ Case Rep 2022 Dec 7;15(12) doi: 10.1136/bcr-2022-251927. PMID: 36593611Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Trotter's triad.
Sakthivel P, Mohamed A, Guwariya M, Chirom AS
BMJ Case Rep 2020 Sep 8;13(9) doi: 10.1136/bcr-2020-237392. PMID: 32907871Free PMC Article

Therapy

Cancer of the Larynx and Hypopharynx.
Echanique KA, Evans LK, Han AY, Chhetri DK, St John MA
Hematol Oncol Clin North Am 2021 Oct;35(5):933-947. Epub 2021 Jul 14 doi: 10.1016/j.hoc.2021.05.005. PMID: 34272102
Clinical practice guideline for the prevention of oral and oropharyngeal mucositis in pediatric cancer and hematopoietic stem cell transplant patients: 2021 update.
Patel P, Robinson PD, Baggott C, Gibson P, Ljungman G, Massey N, Ottaviani G, Phillips R, Revon-Rivière G, Treister N, White M, Cabral S, Dupuis L, Sung L
Eur J Cancer 2021 Sep;154:92-101. Epub 2021 Jul 9 doi: 10.1016/j.ejca.2021.05.013. PMID: 34252760
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape.
Bruce JP, To KF, Lui VWY, Chung GTY, Chan YY, Tsang CM, Yip KY, Ma BBY, Woo JKS, Hui EP, Mak MKF, Lee SD, Chow C, Velapasamy S, Or YYY, Siu PK, El Ghamrasni S, Prokopec S, Wu M, Kwan JSH, Liu Y, Chan JYK, van Hasselt CA, Young LS, Dawson CW, Paterson IC, Yap LF, Tsao SW, Liu FF, Chan ATC, Pugh TJ, Lo KW
Nat Commun 2021 Jul 7;12(1):4193. doi: 10.1038/s41467-021-24348-6. PMID: 34234122Free PMC Article
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Treatment Options for Hypopharyngeal Cancer.
Eckel HE, Bradley PJ
Adv Otorhinolaryngol 2019;83:47-53. Epub 2019 Feb 12 doi: 10.1159/000492308. PMID: 30943512

Prognosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Hypopharyngeal Reconstruction: Possibilities, Outcomes, and Updates for Improving the Human Health for Quality of Life.
Marzouki H, Addas MA, Nujoom M, Zawawi F, Almarzouki HZ, Merdad M
Comput Intell Neurosci 2022;2022:6132481. Epub 2022 Feb 8 doi: 10.1155/2022/6132481. PMID: 35178078Free PMC Article
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Tonsillar carcinoma.
Guay ME, Lavertu P
Eur Arch Otorhinolaryngol 1995;252(5):259-64. doi: 10.1007/BF00185386. PMID: 7576581

Clinical prediction guides

Clinical Characteristics and Prognosis of Small Cell Carcinoma in the Nasopharynx: A Population-Based Study.
Zhou YL, Peng YP, Liu QD, Chen XZ, He J, Wei W, Zhong GH, Zhang YQ, Liu Y, Pan JY, Feng SY, Liu ZG
Cancer Control 2022 Jan-Dec;29:10732748221087075. doi: 10.1177/10732748221087075. PMID: 35341342Free PMC Article
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Head and neck cancer: Current challenges and future perspectives.
Bhat GR, Hyole RG, Li J
Adv Cancer Res 2021;152:67-102. Epub 2021 Jun 16 doi: 10.1016/bs.acr.2021.05.002. PMID: 34353444
Head and neck squamous cell carcinoma.
Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR
Nat Rev Dis Primers 2020 Nov 26;6(1):92. doi: 10.1038/s41572-020-00224-3. PMID: 33243986Free PMC Article
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360

Recent systematic reviews

MRI detection of suspected nasopharyngeal carcinoma: a systematic review and meta-analysis.
Gorolay VV, Niles NN, Huo YR, Ahmadi N, Hanneman K, Thompson E, Chan MV
Neuroradiology 2022 Aug;64(8):1471-1481. Epub 2022 Apr 30 doi: 10.1007/s00234-022-02941-w. PMID: 35499636Free PMC Article
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Signals from the Adipose Microenvironment and the Obesity-Cancer Link-A Systematic Review.
Himbert C, Delphan M, Scherer D, Bowers LW, Hursting S, Ulrich CM
Cancer Prev Res (Phila) 2017 Sep;10(9):494-506. doi: 10.1158/1940-6207.CAPR-16-0322. PMID: 28864539Free PMC Article
Screening for nasopharyngeal cancer.
Yang S, Wu S, Zhou J, Chen XY
Cochrane Database Syst Rev 2015 Nov 6;2015(11):CD008423. doi: 10.1002/14651858.CD008423.pub2. PMID: 26544798Free PMC Article
Gastroesophageal reflux and carcinoma of larynx or pharynx: a meta-analysis.
Zhang D, Zhou J, Chen B, Zhou L, Tao L
Acta Otolaryngol 2014 Oct;134(10):982-9. Epub 2014 Aug 18 doi: 10.3109/00016489.2014.927592. PMID: 25131391

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