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Vulvar neoplasm

MedGen UID:
22689
•Concept ID:
C0042995
•
Neoplastic Process
Synonyms: Neoplasm, Vulva; Neoplasm, Vulvar; Neoplasms, Vulva; Neoplasms, Vulvar; Vulva Neoplasm; Vulva Neoplasms; Vulvar Neoplasm; Vulvar Neoplasms
SNOMED CT: Neoplasm of vulva (126922007); Tumor of vulva (126922007)
 
HPO: HP:0030416
Monarch Initiative: MONDO:0021049

Definition

A tumor (abnormal growth of tissue) of the female external genital tract (vulva). [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulvar neoplasm

Professional guidelines

PubMed

Clinical Features and Treatment of Dermatofibrosarcoma Protuberans Affecting the Vulva: A Literature Review.
Nguyen AH, Detty SQ, Gonzaga MI, Huerter C
Dermatol Surg 2017 Jun;43(6):771-774. doi: 10.1097/DSS.0000000000001113. PMID: 28323651

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

Recent clinical studies

Therapy

Prevalence of human papillomavirus DNA and p16(INK4a) positivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis.
Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Lymphoma Presenting as a Mass of the Vulva: Report of a Case of a Rare Vulvar Neoplasm Not Treated by Surgery.
Wang Q, Cracchiolo B, Heller DS
J Low Genit Tract Dis 2017 Apr;21(2):e26-e27. doi: 10.1097/LGT.0000000000000296. PMID: 28166106
Primary vulvar and vaginal extraosseous Ewing's sarcoma/peripheral neuroectodermal tumor: diagnostic confirmation with CD99 immunostaining and reverse transcriptase-polymerase chain reaction.
Vang R, Taubenberger JK, Mannion CM, Bijwaard K, Malpica A, Ordonez NG, Tavassoli FA, Silver SA
Int J Gynecol Pathol 2000 Apr;19(2):103-9. doi: 10.1097/00004347-200004000-00002. PMID: 10782405

Prognosis

Outcomes and prognostic factors of surgically treated extramammary Paget's disease of the vulva.
Cho A, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Park JY
J Gynecol Oncol 2023 Nov;34(6):e76. Epub 2023 Jul 5 doi: 10.3802/jgo.2023.34.e76. PMID: 37477099Free PMC Article
Measuring the depth of invasion in vulvar squamous cell carcinoma: interobserver agreement and pitfalls.
Pouwer AW, Bult P, Otte I, van der Brand M, van der Horst J, Harterink LJV, van de Vijver KK, Guerra E, Aliredjo RP, Bosch SL, M M Grefte J, Zomer S, Hollema H, de Heus B, Satumalaij S, Ewing-Graham PC, IntHout J, de Hullu JA, Bulten J
Histopathology 2019 Sep;75(3):413-420. Epub 2019 Jul 26 doi: 10.1111/his.13883. PMID: 31021414Free PMC Article
Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Clinical Features and Treatment of Dermatofibrosarcoma Protuberans Affecting the Vulva: A Literature Review.
Nguyen AH, Detty SQ, Gonzaga MI, Huerter C
Dermatol Surg 2017 Jun;43(6):771-774. doi: 10.1097/DSS.0000000000001113. PMID: 28323651
Paget disease of the vulva.
van der Linden M, Meeuwis KA, Bulten J, Bosse T, van Poelgeest MI, de Hullu JA
Crit Rev Oncol Hematol 2016 May;101:60-74. Epub 2016 Mar 4 doi: 10.1016/j.critrevonc.2016.03.008. PMID: 26971063

Clinical prediction guides

Outcomes and prognostic factors of surgically treated extramammary Paget's disease of the vulva.
Cho A, Kim DY, Suh DS, Kim JH, Kim YM, Kim YT, Park JY
J Gynecol Oncol 2023 Nov;34(6):e76. Epub 2023 Jul 5 doi: 10.3802/jgo.2023.34.e76. PMID: 37477099Free PMC Article
Myoepithelioma-like tumors of the vulvar region: A case report and review of the literature.
Liu X, Chen L, Zhou Q, Liu J, Hu Y
J Obstet Gynaecol Res 2022 Jul;48(7):2015-2020. Epub 2022 May 17 doi: 10.1111/jog.15286. PMID: 35581677
Measuring the depth of invasion in vulvar squamous cell carcinoma: interobserver agreement and pitfalls.
Pouwer AW, Bult P, Otte I, van der Brand M, van der Horst J, Harterink LJV, van de Vijver KK, Guerra E, Aliredjo RP, Bosch SL, M M Grefte J, Zomer S, Hollema H, de Heus B, Satumalaij S, Ewing-Graham PC, IntHout J, de Hullu JA, Bulten J
Histopathology 2019 Sep;75(3):413-420. Epub 2019 Jul 26 doi: 10.1111/his.13883. PMID: 31021414Free PMC Article

Recent systematic reviews

Prevalence of human papillomavirus DNA and p16(INK4a) positivity in vulvar cancer and vulvar intraepithelial neoplasia: a systematic review and meta-analysis.
Li Z, Liu P, Wang Z, Zhang Z, Chen Z, Chu R, Li G, Han Q, Zhao Y, Li L, Miao J, Kong B, Song K
Lancet Oncol 2023 Apr;24(4):403-414. Epub 2023 Mar 15 doi: 10.1016/S1470-2045(23)00066-9. PMID: 36933562
Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review.
Te Grootenhuis NC, Pouwer AW, de Bock GH, Hollema H, Bulten J, van der Zee AGJ, de Hullu JA, Oonk MHM
Gynecol Oncol 2018 Mar;148(3):622-631. Epub 2017 Nov 12 doi: 10.1016/j.ygyno.2017.11.006. PMID: 29137809
Limiting the morbidity of inguinofemoral lymphadenectomy in vulvar cancer patients; a review.
Pouwer AW, Arts HJ, van der Velden J, de Hullu JA
Expert Rev Anticancer Ther 2017 Jul;17(7):615-624. Epub 2017 Jun 13 doi: 10.1080/14737140.2017.1337513. PMID: 28608762

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
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    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Vulvar Cancer, 2024

    Consumer resources

    Reviews

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