Neoplasm of the small intestine

MedGen UID:: 91055
•Concept ID:: C0345832
•: Neoplastic Process

Synonyms:	Neoplasm of Small Bowel; neoplasm of small bowel; Neoplasm of small intestine; Neoplasm of Small Intestine; neoplasm of small intestine; Neoplasm of the Small Bowel; neoplasm of the small bowel; Neoplasm of the Small Intestine; neoplasm of the small intestine; Small Bowel Neoplasm; small bowel neoplasm; Small Bowel Tumor; small bowel tumor; small bowel tumour; Small Intestinal Neoplasm; small intestinal neoplasm; Small Intestine Neoplasm; small intestine neoplasm; small intestine neoplasm (disease); Small Intestine Tumor; Small intestine tumor; small intestine tumor; Small intestine tumour; small intestine tumour; Tumor of Small Bowel; tumor of small bowel; Tumor of small intestine; Tumor of Small Intestine; tumor of small intestine; Tumor of the Small Bowel; tumor of the small bowel; Tumor of the Small Intestine; tumor of the small intestine; tumour of small bowel; tumour of small intestine; tumour of the small bowel; tumour of the small intestine
SNOMED CT:	Neoplasm of small intestine (126832004); Tumor of small intestine (126832004)

HPO:	HP:0100833
Monarch Initiative:	MONDO:0004251

Definition

The presence of a neoplasm of the small intestine. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeoplasm of the small intestine

Pathological process
- Disease
  - Disorder by Site
    - Disorder of gastrointestinal tract
      - Intestinal disorder
        Intestinal neoplasm
        Neoplasm of the small intestine
        Benign neoplasm of small intestine
        Adenoma of small intestine
        Duodenal Adenoma
        Small intestinal tubular adenoma
        Small intestinal tubulovillous adenoma
        Small Intestinal Villous Adenoma
        Benign duodenal neoplasm
        Benign Periampullary Neoplasm
        Small Intestinal Lipoma
        Small intestine leiomyoma
        Duodenal gastrin-producing neuroendocrine tumor
        Gastrointestinal stromal tumor of small intestine
        Stage I Small Intestinal Gastrointestinal Stromal Tumor
        Stage II Small Intestinal Gastrointestinal Stromal Tumor
        Stage IIIA Small Intestinal Gastrointestinal Stromal Tumor
        Stage IIIB Small Intestinal Gastrointestinal Stromal Tumor
        Stage IV Small Intestinal Gastrointestinal Stromal Tumor
        Ileal neoplasm
        Ileal neuroendocrine tumor, well differentiated, low or intermediate grade
        Ileal Neuroendocrine Tumor by AJCC v8 Stage
        Ileal neuroendocrine tumor G1
        Ileal Neuroendocrine Tumor G2
        Ileal Neuroendocrine Tumor G3
        Jejunal neoplasm
        Jejunal cancer
        Jejunal Carcinoma
        Jejunal neuroendocrine tumor, well differentiated, low or intermediate grade
        Jejunal Neuroendocrine Tumor by AJCC v8 Stage
        Jejunal neuroendocrine tumor G1
        Jejunal Neuroendocrine Tumor G2
        Jejunal Neuroendocrine Tumor G3
        Jejunal somatostatinoma
        Somatostatinoma
        Malignant tumor of small intestine
        Childhood Malignant Small Intestinal Neoplasm
        Childhood Small Intestinal Carcinoma
        Childhood Small Intestinal Leiomyosarcoma
        Duodenum cancer
        Ampulla of vater cancer
        Carcinoma of duodenum
        Duodenal Extraskeletal Osteosarcoma
        Recurrent Malignant Duodenal Neoplasm
        Metastatic Malignant Neoplasm in the Small Intestine
        Metastatic Malignant Small Intestinal Neoplasm
        Advanced Malignant Small Intestinal Neoplasm
        Metastatic Small Intestinal Carcinoma
        Small Intestinal Myeloid Sarcoma
        Small intestinal sarcoma
        Small Intestinal Angiosarcoma
        Small intestinal fibrosarcoma
        Small Intestinal Kaposi Sarcoma
        Small intestine leiomyosarcoma
        Small intestine carcinoma
        Recurrent Small Intestinal Carcinoma
        Refractory Small Intestinal Carcinoma
        Resectable Small Intestinal Carcinoma
        Small Intestinal Adenosquamous Carcinoma
        Small Intestinal Cancer by AJCC v7 Stage
        Small Intestinal Medullary Carcinoma
        Small Intestinal Mixed Adenoneuroendocrine Carcinoma
        Small Intestinal Neuroendocrine Carcinoma
        Small Intestinal Undifferentiated Carcinoma
        Small intestine adenocarcinoma
        Squamous cell carcinoma of the small intestine
        Unresectable Small Intestinal Carcinoma
        Small intestine lymphoma
        Small Intestinal Hodgkin Lymphoma
        Small Intestinal Non-Hodgkin Lymphoma
        Small intestinal adenoma
        Small intestinal hamartoma
        Small intestinal intraepithelial neoplasia
        Small Intestinal High Grade Intraepithelial Neoplasia
        Small Intestinal Low Grade Intraepithelial Neoplasia
        Small intestinal polyp
        Juvenile Polyp of the Small Intestine
        Peutz-Jeghers Polyp of the Small Intestine
        Small intestine carcinoid
        Small intestine neuroendocrine neoplasm
        Small intestine neuroendocrine tumor, well differentiated, low or intermediate grade
        Duodenal neuroendocrine tumor, well differentiated, low or intermediate grade
        Small Intestinal Composite Gangliocytoma/Neuroma and Neuroendocrine Tumor
        Small Intestinal Enterochromaffin Cell Serotonin-Producing Neuroendocrine Tumor
        Small Intestinal Gastrin-Producing Neuroendocrine Tumor
        Small intestinal L-cell glucagon-like peptide producing tumor
        Small intestinal neuroendocrine tumor G1
        Small Intestinal Neuroendocrine Tumor G2
        Small Intestinal Neuroendocrine Tumor G3
        Small Intestinal Somatostatin-Producing Neuroendocrine Tumor
        Small intestinal vasoactive intestinal peptide producing tumor
        Tumor of duodenum

Professional guidelines

PubMed

Clinical Guidelines for Diagnosis and Management of Peutz-Jeghers Syndrome in Children and Adults.

Yamamoto H, Sakamoto H, Kumagai H, Abe T, Ishiguro S, Uchida K, Kawasaki Y, Saida Y, Sano Y, Takeuchi Y, Tajika M, Nakajima T, Banno K, Funasaka Y, Hori S, Yamaguchi T, Yoshida T, Ishikawa H, Iwama T, Okazaki Y, Saito Y, Matsuura N, Mutoh M, Tomita N, Akiyama T, Yamamoto T, Ishida H, Nakayama Y
Digestion 2023;104(5):335-347. Epub 2023 Apr 13 doi: 10.1159/000529799. PMID: 37054692

Management of Incidentalomas.

Reidelberger K, Fingeret A
Surg Clin North Am 2021 Dec;101(6):1081-1096. doi: 10.1016/j.suc.2021.06.006. PMID: 34774270

A Systematic Review of the Clinical Presentation, Diagnosis, and Treatment of Small Bowel Obstruction.

Rami Reddy SR, Cappell MS
Curr Gastroenterol Rep 2017 Jun;19(6):28. doi: 10.1007/s11894-017-0566-9. PMID: 28439845

See all (591)

Recent clinical studies

Etiology

Chromogranin A (CgA) as a biomarker in carcinoid heart disease and NETG1/G2 neuroendocrine neoplasms of the small intestine (SI-NENs) related carcinoid syndrome.

Konsek-Komorowska SJ, Pęczkowska M, Kolasińska-Ćwikła AD, Konka M, Chrapowicki E, Ćwikła JB
Med Clin (Barc) 2022 Jul 22;159(2):85-89. Epub 2021 Nov 1 doi: 10.1016/j.medcli.2021.06.029. PMID: 34736622

Review of a non-epithelial tumour of the small bowel after c-kit revolution.

Fiori E, Ferraro D, De Cesare A, Leone G, Barmann C, Schillaci A, Borrini F
Ann Ital Chir 2016;87:183-5. PMID: 27179285

See all (2)

Diagnosis

Chromogranin A (CgA) as a biomarker in carcinoid heart disease and NETG1/G2 neuroendocrine neoplasms of the small intestine (SI-NENs) related carcinoid syndrome.

Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors.

Zhang Z, Mäkinen N, Kasai Y, Kim GE, Diosdado B, Nakakura E, Meyerson M
Genes Chromosomes Cancer 2020 Sep;59(9):535-539. Epub 2020 Apr 27 doi: 10.1002/gcc.22850. PMID: 32291827 Free PMC Article

Review of a non-epithelial tumour of the small bowel after c-kit revolution.

Fiori E, Ferraro D, De Cesare A, Leone G, Barmann C, Schillaci A, Borrini F
Ann Ital Chir 2016;87:183-5. PMID: 27179285

See all (3)