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Precursor lymphoblastic lymphoma/leukemia

MedGen UID:
235492
Concept ID:
C1335469
Neoplastic Process
Synonyms: Precursor Lymphoblastic Leukemia/Lymphoma; precursor lymphoblastic leukemia/lymphoma; Precursor Lymphoblastic Lymphoma/Leukemia; precursor lymphoblastic lymphoma/leukemia; Precursor Lymphoid Neoplasm; precursor lymphoid neoplasm
 
Monarch Initiative: MONDO:0003538

Definition

A neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage. Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias. Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrecursor lymphoblastic lymphoma/leukemia

Professional guidelines

PubMed

Alexander TB, Orgel E
Curr Oncol Rep 2021 Feb 5;23(2):22. doi: 10.1007/s11912-020-01010-w. PMID: 33544265
Rafei H, Kantarjian HM, Jabbour EJ
Leuk Lymphoma 2019 Nov;60(11):2606-2621. Epub 2019 May 16 doi: 10.1080/10428194.2019.1605071. PMID: 31092071
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423

Recent clinical studies

Etiology

Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Coccaro N, Anelli L, Zagaria A, Specchia G, Albano F
Int J Mol Sci 2019 Jun 15;20(12) doi: 10.3390/ijms20122929. PMID: 31208040Free PMC Article

Diagnosis

Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Inaba H, Mullighan CG
Haematologica 2020 Nov 1;105(11):2524-2539. doi: 10.3324/haematol.2020.247031. [Epub ahead of print] PMID: 33054110Free PMC Article
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Onciu M
Hematol Oncol Clin North Am 2009 Aug;23(4):655-74. doi: 10.1016/j.hoc.2009.04.009. PMID: 19577163

Therapy

Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Rafei H, Kantarjian HM, Jabbour EJ
Leuk Lymphoma 2019 Nov;60(11):2606-2621. Epub 2019 May 16 doi: 10.1080/10428194.2019.1605071. PMID: 31092071
Aldoss I, Stein AS
Leuk Lymphoma 2018 May;59(5):1033-1050. Epub 2017 Jul 26 doi: 10.1080/10428194.2017.1354372. PMID: 28745565
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520

Prognosis

Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520
Hunger SP, Mullighan CG
N Engl J Med 2015 Oct 15;373(16):1541-52. doi: 10.1056/NEJMra1400972. PMID: 26465987
Onciu M
Hematol Oncol Clin North Am 2009 Aug;23(4):655-74. doi: 10.1016/j.hoc.2009.04.009. PMID: 19577163

Clinical prediction guides

Lejman M, Chałupnik A, Chilimoniuk Z, Dobosz M
Int J Mol Sci 2022 Mar 2;23(5) doi: 10.3390/ijms23052755. PMID: 35269896Free PMC Article
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199
Aldoss I, Stein AS
Leuk Lymphoma 2018 May;59(5):1033-1050. Epub 2017 Jul 26 doi: 10.1080/10428194.2017.1354372. PMID: 28745565
Larson RA
Leuk Lymphoma 2018 Jan;59(1):3-13. Epub 2017 May 23 doi: 10.1080/10428194.2017.1326597. PMID: 28535095

Recent systematic reviews

Kołodrubiec J, Kozłowska M, Irga-Jaworska N, Sędek Ł, Pastorczak A, Trelińska J, Młynarski W
Leuk Res 2022 Oct;121:106925. Epub 2022 Aug 2 doi: 10.1016/j.leukres.2022.106925. PMID: 35939887
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
Coombs A, Schilperoort H, Sargent B
Crit Rev Oncol Hematol 2020 Aug;152:103004. Epub 2020 May 27 doi: 10.1016/j.critrevonc.2020.103004. PMID: 32580035Free PMC Article

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