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Precursor lymphoblastic lymphoma/leukemia

MedGen UID:
235492
•Concept ID:
C1335469
•
Neoplastic Process
Synonyms: Precursor Lymphoblastic Leukemia/Lymphoma; precursor lymphoblastic leukemia/lymphoma; Precursor Lymphoblastic Lymphoma/Leukemia; precursor lymphoblastic lymphoma/leukemia; Precursor Lymphoid Neoplasm; precursor lymphoid neoplasm
 
Monarch Initiative: MONDO:0003538

Definition

A neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage. Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias. Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPrecursor lymphoblastic lymphoma/leukemia

Professional guidelines

PubMed

Diagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Temple WC, Mueller S, Hermiston ML, Burkhardt B
Best Pract Res Clin Haematol 2023 Mar;36(1):101449. Epub 2023 Feb 16 doi: 10.1016/j.beha.2023.101449. PMID: 36907639
Adult Acute Lymphoblastic Leukemia: Treatment and Management Updates.
Gregory S
Semin Oncol Nurs 2019 Dec;35(6):150951. Epub 2019 Nov 20 doi: 10.1016/j.soncn.2019.150951. PMID: 31759820
Treatment and biology of pediatric acute lymphoblastic leukemia.
Kato M, Manabe A
Pediatr Int 2018 Jan;60(1):4-12. doi: 10.1111/ped.13457. PMID: 29143423

Recent clinical studies

Etiology

International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Recent Advances in Managing Acute Lymphoblastic Leukemia.
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Biology of childhood acute lymphoblastic leukemia.
Bhojwani D, Yang JJ, Pui CH
Pediatr Clin North Am 2015 Feb;62(1):47-60. doi: 10.1016/j.pcl.2014.09.004. PMID: 25435111Free PMC Article

Diagnosis

International Consensus Classification of acute lymphoblastic leukemia/lymphoma.
Duffield AS, Mullighan CG, Borowitz MJ
Virchows Arch 2023 Jan;482(1):11-26. Epub 2022 Nov 24 doi: 10.1007/s00428-022-03448-8. PMID: 36422706Free PMC Article
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Acute lymphoblastic leukemia.
Onciu M
Hematol Oncol Clin North Am 2009 Aug;23(4):655-74. doi: 10.1016/j.hoc.2009.04.009. PMID: 19577163

Therapy

Immunotherapy in leukaemia.
Mu X, Chen C, Dong L, Kang Z, Sun Z, Chen X, Zheng J, Zhang Y
Acta Biochim Biophys Sin (Shanghai) 2023 Jun 2;55(6):974-987. doi: 10.3724/abbs.2023101. PMID: 37272727Free PMC Article
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Immunotherapy in pediatric acute lymphoblastic leukemia.
Inaba H, Pui CH
Cancer Metastasis Rev 2019 Dec;38(4):595-610. doi: 10.1007/s10555-019-09834-0. PMID: 31811553Free PMC Article
Treatment of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia.
Abou Dalle I, Jabbour E, Short NJ, Ravandi F
Curr Treat Options Oncol 2019 Jan 24;20(1):4. doi: 10.1007/s11864-019-0603-z. PMID: 30675645Free PMC Article
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520

Prognosis

Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
Update on Lymphoblastic Leukemia/Lymphoma.
Luca DC
Clin Lab Med 2021 Sep;41(3):405-416. doi: 10.1016/j.cll.2021.04.003. PMID: 34304772
Acute lymphoblastic leukemia.
Chang JH, Poppe MM, Hua CH, Marcus KJ, Esiashvili N
Pediatr Blood Cancer 2021 May;68 Suppl 2:e28371. doi: 10.1002/pbc.28371. PMID: 33818880
Acute lymphoblastic leukaemia.
Malard F, Mohty M
Lancet 2020 Apr 4;395(10230):1146-1162. doi: 10.1016/S0140-6736(19)33018-1. PMID: 32247396
Acute Lymphoblastic Leukemia in Children.
Hunger SP, Mullighan CG
N Engl J Med 2015 Oct 15;373(16):1541-52. doi: 10.1056/NEJMra1400972. PMID: 26465987

Clinical prediction guides

Management of Down Syndrome-Associated Leukemias: A Review.
Verma A, Lupo PJ, Shah NN, Hitzler J, Rabin KR
JAMA Oncol 2023 Sep 1;9(9):1283-1290. doi: 10.1001/jamaoncol.2023.2163. PMID: 37440251
MRD in ALL: Optimization and Innovations.
Pierce E, Mautner B, Mort J, Blewett A, Morris A, Keng M, El Chaer F
Curr Hematol Malig Rep 2022 Aug;17(4):69-81. Epub 2022 May 26 doi: 10.1007/s11899-022-00664-6. PMID: 35616771
Lymphoblastic Lymphoma: a Concise Review.
Intermesoli T, Weber A, Leoncin M, Frison L, Skert C, Bassan R
Curr Oncol Rep 2022 Jan;24(1):1-12. Epub 2022 Jan 20 doi: 10.1007/s11912-021-01168-x. PMID: 35059993
How I treat relapsed acute lymphoblastic leukemia in the pediatric population.
Hunger SP, Raetz EA
Blood 2020 Oct 15;136(16):1803-1812. doi: 10.1182/blood.2019004043. PMID: 32589723
Acute Lymphoblastic Leukemia in the Older Adult.
Aldoss I, Forman SJ, Pullarkat V
J Oncol Pract 2019 Feb;15(2):67-75. doi: 10.1200/JOP.18.00271. PMID: 30763199

Recent systematic reviews

Systematic Review and Meta-analysis of CD19-Specific CAR-T Cell Therapy in Relapsed/Refractory Acute Lymphoblastic Leukemia in the Pediatric and Young Adult Population: Safety and Efficacy Outcomes.
Aamir S, Anwar MY, Khalid F, Khan SI, Ali MA, Khattak ZE
Clin Lymphoma Myeloma Leuk 2021 Apr;21(4):e334-e347. Epub 2020 Dec 17 doi: 10.1016/j.clml.2020.12.010. PMID: 33573914
Philadelphia-Like Acute Lymphoblastic Leukemia: A Systematic Review.
Yadav V, Ganesan P, Veeramani R, Kumar V D
Clin Lymphoma Myeloma Leuk 2021 Jan;21(1):e57-e65. Epub 2020 Aug 18 doi: 10.1016/j.clml.2020.08.011. PMID: 33485429
The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systematic review.
Coombs A, Schilperoort H, Sargent B
Crit Rev Oncol Hematol 2020 Aug;152:103004. Epub 2020 May 27 doi: 10.1016/j.critrevonc.2020.103004. PMID: 32580035Free PMC Article
Relapse Prevention with Tyrosine Kinase Inhibitors after Allogeneic Transplantation for Philadelphia Chromosome-Positive Acute Lymphoblast Leukemia: A Systematic Review.
Warraich Z, Tenneti P, Thai T, Hubben A, Amin H, McBride A, Warraich S, Hannan A, Warraich F, Majhail N, Kalaycio M, Anwer F
Biol Blood Marrow Transplant 2020 Mar;26(3):e55-e64. Epub 2019 Sep 23 doi: 10.1016/j.bbmt.2019.09.022. PMID: 31557532
Physical exercise training interventions for children and young adults during and after treatment for childhood cancer.
Braam KI, van der Torre P, Takken T, Veening MA, van Dulmen-den Broeder E, Kaspers GJ
Cochrane Database Syst Rev 2016 Mar 31;3(3):CD008796. doi: 10.1002/14651858.CD008796.pub3. PMID: 27030386Free PMC Article

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