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Pancreatobiliary Carcinoma

MedGen UID:: 1715998
•Concept ID:: C5237970
•: Neoplastic Process

Synonyms:

Pancreaticobiliary Cancer; Pancreaticobiliary Carcinoma; Pancreatobiliary Cancer

Definition

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVPancreatobiliary Carcinoma

Pathological process
- Disease
  - Neoplasm
    - Epithelial neoplasm
      - Carcinoma
        Gastrointestinal carcinoma
        Pancreatobiliary Carcinoma
        Ampulla of Vater carcinoma
        Ampulla of vater adenocarcinoma
        Ampulla of vater clear cell adenocarcinoma
        Ampulla of Vater Hepatoid Adenocarcinoma
        Ampulla of Vater Intestinal-Type Adenocarcinoma
        Ampulla of Vater Invasive Papillary Adenocarcinoma
        Ampulla of vater mucinous adenocarcinoma
        Ampulla of Vater Pancreatobiliary Type Adenocarcinoma
        Ampullary signet ring cell adenocarcinoma
        Recurrent Ampulla of Vater Adenocarcinoma
        Ampulla of vater adenosquamous carcinoma
        Ampulla of Vater Cancer by AJCC v7 Stage
        Stage 0 Ampulla of Vater Cancer AJCC v7
        Stage I Ampulla of Vater Cancer AJCC v7
        Stage II Ampulla of Vater Cancer AJCC v7
        Stage III Ampulla of Vater Cancer AJCC v7
        Stage IV Ampulla of Vater Cancer AJCC v7
        Ampulla of Vater Cancer by AJCC v8 Stage
        Stage 0 Ampulla of Vater Cancer AJCC v8
        Stage I Ampulla of Vater Cancer AJCC v8
        Stage II Ampulla of Vater Cancer AJCC v8
        Stage III Ampulla of Vater Cancer AJCC v8
        Stage IV Ampulla of Vater Cancer AJCC v8
        Ampulla of Vater Mixed Adenoneuroendocrine Carcinoma
        Ampulla of Vater Neuroendocrine Carcinoma
        Ampulla of Vater Large Cell Neuroendocrine Carcinoma
        Ampulla of vater small cell neuroendocrine carcinoma
        Ampulla of vater squamous cell carcinoma
        Ampulla of Vater Undifferentiated Carcinoma
        Ampulla of Vater Undifferentiated Carcinoma with Osteoclast-Like Giant Cells
        Metastatic Ampulla of Vater Carcinoma
        Advanced Ampulla of Vater Carcinoma
        Locally Advanced Ampulla of Vater Carcinoma
        Refractory Ampulla of Vater Carcinoma
        Unresectable Ampulla of Vater Carcinoma
        Biliary Tract Carcinoma
        Bile duct carcinoma
        Bile duct adenocarcinoma
        Extrahepatic bile duct carcinoma
        Metastatic Bile Duct Carcinoma
        Recurrent Bile Duct Carcinoma
        Refractory Bile Duct Carcinoma
        Unresectable Bile Duct Carcinoma
        Gallbladder carcinoma
        Gallbladder adenocarcinoma
        Gallbladder adenosquamous carcinoma
        Gallbladder Cancer by AJCC v6 Stage
        Gallbladder Cancer by AJCC v7 Stage
        Gallbladder Cancer by AJCC v8 Stage
        Gallbladder Carcinosarcoma
        Gallbladder Mixed Adenoneuroendocrine Carcinoma
        Gallbladder Neuroendocrine Carcinoma
        Gallbladder squamous cell carcinoma
        Incidental Gallbladder Carcinoma
        Localized Gallbladder Carcinoma
        Metastatic Gallbladder Carcinoma
        Recurrent Gallbladder Carcinoma
        Refractory Gallbladder Carcinoma
        Undifferentiated gallbladder carcinoma
        Unresectable Gallbladder Carcinoma
        High-Grade Biliary Intraepithelial Neoplasia
        Metastatic Biliary Tract Carcinoma
        Advanced Biliary Tract Carcinoma
        Locally Advanced Biliary Tract Carcinoma
        Recurrent Biliary Tract Carcinoma
        Refractory Biliary Tract Carcinoma
        Unresectable Biliary Tract Carcinoma
        Carcinoma of pancreas
        Familial pancreatic carcinoma
        Metastatic Pancreatic Carcinoma
        Advanced Pancreatic Carcinoma
        Locally Advanced Pancreatic Carcinoma
        Metastatic Pancreatic Adenocarcinoma
        Pancreatic acinar cell carcinoma
        Pancreatic acinar cell cystadenocarcinoma
        Recurrent Pancreatic Acinar Cell Carcinoma
        Resectable Pancreatic Acinar Cell Carcinoma
        Pancreatic adenocarcinoma
        Invasive Pancreatic Micropapillary Adenocarcinoma
        Localized Pancreatic Adenocarcinoma
        Pancreatic cystadenocarcinoma
        Pancreatic ductal adenocarcinoma
        Pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma
        Pancreatic Intraductal Tubulopapillary Neoplasm with an Associated Invasive Carcinoma
        Pancreatic Mixed Acinar-Ductal Carcinoma
        Recurrent Pancreatic Adenocarcinoma
        Refractory Pancreatic Adenocarcinoma
        Resectable Pancreatic Adenocarcinoma
        Unresectable Pancreatic Adenocarcinoma
        Pancreatic adenosquamous carcinoma
        Resectable Pancreatic Adenosquamous Carcinoma
        Pancreatic Cancer by AJCC v6 and v7 Stage
        Stage 0 Pancreatic Cancer AJCC v6 and v7
        Stage I Pancreatic Cancer AJCC v6 and v7
        Stage II Pancreatic Cancer AJCC v6 and v7
        Stage III Pancreatic Cancer AJCC v6 and v7
        Stage IV Pancreatic Cancer AJCC v6 and v7
        Pancreatic Cancer by AJCC v8 Stage
        Stage 0 Pancreatic Cancer AJCC v8
        Stage I Pancreatic Cancer AJCC v8
        Stage II Pancreatic Cancer AJCC v8
        Stage III Pancreatic Cancer AJCC v8
        Stage IV Pancreatic Cancer AJCC v8
        Pancreatic carcinoma with mixed differentiation
        Pancreatic Mixed Acinar-Ductal Neuroendocrine Carcinoma
        Pancreatic Mixed Acinar-Neuroendocrine Carcinoma
        Pancreatic Mixed Ductal-Neuroendocrine Carcinoma
        Pancreatic intraductal papillary-mucinous carcinoma
        Pancreatic mucinous cystadenoma
        Pancreatic serous cystadenocarcinoma
        Pancreatic squamous cell carcinoma
        Recurrent Pancreatic Carcinoma
        Refractory Pancreatic Carcinoma
        Resectable Pancreatic Carcinoma
        Solid pseudopapillary carcinoma of pancreas
        Undifferentiated pancreatic carcinoma with osteoclast-like giant cells
        Unresectable Pancreatic Carcinoma
        Metastatic Pancreatobiliary Carcinoma
        Advanced Pancreatobiliary Carcinoma
        Locally Advanced Pancreatobiliary Carcinoma

Professional guidelines

PubMed

Expert consensus on the management of adverse events in patients receiving lenvatinib for hepatocellular carcinoma.

Kim BH, Yu SJ, Kang W, Cho SB, Park SY, Kim SU, Kim DY
J Gastroenterol Hepatol 2022 Mar;37(3):428-439. Epub 2021 Nov 17 doi: 10.1111/jgh.15727. PMID: 34725855 Free PMC Article

New criteria of resectability for pancreatic cancer: A position paper by the Japanese Society of Hepato-Biliary-Pancreatic Surgery (JSHBPS).

Oba A, Del Chiaro M, Satoi S, Kim SW, Takahashi H, Yu J, Hioki M, Tanaka M, Kato Y, Ariake K, Wu YHA, Inoue Y, Takahashi Y, Hackert T, Wolfgang CL, Besselink MG, Schulick RD, Nagakawa Y, Isaji S, Tsuchida A, Endo I
J Hepatobiliary Pancreat Sci 2022 Jul;29(7):725-731. Epub 2021 Oct 20 doi: 10.1002/jhbp.1049. PMID: 34581016

Treatment Approach to Adenocarcinoma of the Ampulla of Vater.

Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537

See all (33)

Recent clinical studies

Etiology

SPARC expression in desmoplastic and non desmoplastic pancreatic carcinoma and cholangiocarcinoma.

Khetan K, Baloda V, Sahoo RK, Vishnubhathla S, Yadav R, Saraya A, Sharma A, Gupta SD, Das P
Pathol Res Pract 2019 Dec;215(12):152685. Epub 2019 Oct 21 doi: 10.1016/j.prp.2019.152685. PMID: 31727501

Dysplasia in Gallbladder: What Should We Do?

Rais R, González I, Chatterjee D
J Gastrointest Surg 2019 Apr;23(4):686-689. Epub 2018 Sep 13 doi: 10.1007/s11605-018-3955-y. PMID: 30215198

Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma.

Miyata T, Kitano M, Omoto S, Kadosaka K, Kamata K, Imai H, Sakamoto H, Nisida N, Harwani Y, Murakami T, Takeyama Y, Chiba Y, Kudo M
World J Gastroenterol 2016 Mar 28;22(12):3381-91. doi: 10.3748/wjg.v22.i12.3381. PMID: 27022220 Free PMC Article

Strategies for improving diagnostic accuracy of biliary strictures.

Salomao M, Gonda TA, Margolskee E, Eguia V, Remotti H, Poneros JM, Sethi A, Saqi A
Cancer Cytopathol 2015 Apr;123(4):244-52. Epub 2015 Jan 6 doi: 10.1002/cncy.21509. PMID: 25564796

Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging.

Chung YE, Kim MJ, Park MS, Choi JY, Kim H, Kim SK, Lee M, Kim HJ, Choi JS, Song SY, Kim KW
Radiology 2010 Nov;257(2):384-93. Epub 2010 Sep 9 doi: 10.1148/radiol.10100200. PMID: 20829529

See all (11)

Diagnosis

Dysplasia in Gallbladder: What Should We Do?

Rais R, González I, Chatterjee D
J Gastrointest Surg 2019 Apr;23(4):686-689. Epub 2018 Sep 13 doi: 10.1007/s11605-018-3955-y. PMID: 30215198

Pathologic Subtypes of Ampullary Adenocarcinoma: Value of Ampullary MDCT for Noninvasive Preoperative Differentiation.

Ivanovic AM, Alessandrino F, Maksimovic R, Micev M, Ostojic S, Gore RM, Mortele KJ
AJR Am J Roentgenol 2017 Mar;208(3):W71-W78. Epub 2017 Jan 17 doi: 10.2214/AJR.16.16723. PMID: 28095024

FISHing for pancreatobiliary tract malignancy in endoscopic brushings enhances the sensitivity of routine cytology.

Barr Fritcher EG, Kipp BR, Halling KC, Clayton AC
Cytopathology 2014 Oct;25(5):288-301. Epub 2014 Jul 30 doi: 10.1111/cyt.12170. PMID: 25073411

Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging.

Chung YE, Kim MJ, Park MS, Choi JY, Kim H, Kim SK, Lee M, Kim HJ, Choi JS, Song SY, Kim KW
Radiology 2010 Nov;257(2):384-93. Epub 2010 Sep 9 doi: 10.1148/radiol.10100200. PMID: 20829529

Diagnosis of portal venous invasion by pancreatobiliary carcinoma: value of endoscopic ultrasonography.

Sugiyama M, Hagi H, Atomi Y, Saito M
Abdom Imaging 1997 Jul-Aug;22(4):434-8. doi: 10.1007/s002619900227. PMID: 9157867

See all (23)

Therapy

Extrapancreatic neural plexus invasion by carcinomas of the pancreatic head region: evaluation using thin-section helical CT.

Tian H, Mori H, Matsumoto S, Yamada Y, Kiyosue H, Ohta M, Kitano S
Radiat Med 2007 May;25(4):141-7. Epub 2007 May 28 doi: 10.1007/s11604-006-0115-1. PMID: 17514364

Intraportal endovascular ultrasonography in the diagnosis of portal vein invasion by pancreatobiliary carcinoma.

Kaneko T, Nakao A, Inoue S, Harada A, Nonami T, Itoh S, Endo T, Takagi H
Ann Surg 1995 Dec;222(6):711-8. doi: 10.1097/00000658-199512000-00004. PMID: 8526577 Free PMC Article

See all (2)

Prognosis

SPARC expression in desmoplastic and non desmoplastic pancreatic carcinoma and cholangiocarcinoma.

Khetan K, Baloda V, Sahoo RK, Vishnubhathla S, Yadav R, Saraya A, Sharma A, Gupta SD, Das P
Pathol Res Pract 2019 Dec;215(12):152685. Epub 2019 Oct 21 doi: 10.1016/j.prp.2019.152685. PMID: 31727501

Dysplasia in Gallbladder: What Should We Do?

Rais R, González I, Chatterjee D
J Gastrointest Surg 2019 Apr;23(4):686-689. Epub 2018 Sep 13 doi: 10.1007/s11605-018-3955-y. PMID: 30215198

Pathologic Subtypes of Ampullary Adenocarcinoma: Value of Ampullary MDCT for Noninvasive Preoperative Differentiation.

Ivanovic AM, Alessandrino F, Maksimovic R, Micev M, Ostojic S, Gore RM, Mortele KJ
AJR Am J Roentgenol 2017 Mar;208(3):W71-W78. Epub 2017 Jan 17 doi: 10.2214/AJR.16.16723. PMID: 28095024

Strategies for improving diagnostic accuracy of biliary strictures.

Salomao M, Gonda TA, Margolskee E, Eguia V, Remotti H, Poneros JM, Sethi A, Saqi A
Cancer Cytopathol 2015 Apr;123(4):244-52. Epub 2015 Jan 6 doi: 10.1002/cncy.21509. PMID: 25564796

Differential features of pancreatobiliary- and intestinal-type ampullary carcinomas at MR imaging.

Chung YE, Kim MJ, Park MS, Choi JY, Kim H, Kim SK, Lee M, Kim HJ, Choi JS, Song SY, Kim KW
Radiology 2010 Nov;257(2):384-93. Epub 2010 Sep 9 doi: 10.1148/radiol.10100200. PMID: 20829529

See all (14)

Clinical prediction guides

Clinicopathological Characteristics of Ovarian Metastasis from Colorectal and Pancreatobiliary Carcinomas Mimicking Primary Ovarian Mucinous Tumor.

Park CK, Kim HS
Anticancer Res 2018 Sep;38(9):5465-5473. doi: 10.21873/anticanres.12879. PMID: 30194204

Pathologic Subtypes of Ampullary Adenocarcinoma: Value of Ampullary MDCT for Noninvasive Preoperative Differentiation.

Ivanovic AM, Alessandrino F, Maksimovic R, Micev M, Ostojic S, Gore RM, Mortele KJ
AJR Am J Roentgenol 2017 Mar;208(3):W71-W78. Epub 2017 Jan 17 doi: 10.2214/AJR.16.16723. PMID: 28095024

Contrast-enhanced harmonic endoscopic ultrasonography for assessment of lymph node metastases in pancreatobiliary carcinoma.

Strategies for improving diagnostic accuracy of biliary strictures.

Salomao M, Gonda TA, Margolskee E, Eguia V, Remotti H, Poneros JM, Sethi A, Saqi A
Cancer Cytopathol 2015 Apr;123(4):244-52. Epub 2015 Jan 6 doi: 10.1002/cncy.21509. PMID: 25564796

Objective assessment of the contribution of each diagnostic test and of the ordering sequence in jaundice caused by pancreatobiliary carcinoma.

de Bree E, Tsiftsis DD, Santos RM, Lavelle SM, Cuervas-Mons V, Gauthier A, Gips C, Malchow-Moeller A, Molino G, Rohr G, Theodossi A, Tsantoulas D
Scand J Gastroenterol 2000 Apr;35(4):438-45. doi: 10.1080/003655200750024038. PMID: 10831270

See all (9)

MedGen

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Send to:

Pancreatobiliary Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

Related information

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