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Series GSE7483 Query DataSets for GSE7483
Status Public on Apr 11, 2007
Title Microarray analysis of aortic tissue from different rat hypertensive models
Organism Rattus norvegicus
Experiment type Expression profiling by array
Summary To determine if there exists a consistent gene signature associated with vascular hypertrophy among different rat hypertensive models: treated and untreated Wistar Kyoto (WKY) rats and treated and untreated Spontaneous Hypertensive Rat (SHR) rats.
Keywords: strain comparison, treatment vs control
 
Overall design Two strains of rat were studies: WKY which are normotensive and SHR which are hypertensive. Aortic tissue was taken from 6 untreated WKY rats and 6 WKY rats treated with angiotensin. Aortic tissue was taken from 6 untreated SHR rats, 6 treated with nifedipine for two weeks and 5 treated with nifedipine for two weeks and then washed out for three weeks. There was a total of 29 samples. A pool of RNA from 6 untreated WKY rats was used as a reference. Hybridizations were performed in duplicate with a dye-flip and always with the reference as the second color.
 
Contributor(s) Pritchard D, Wang X, Marchand E, Amon LM, Duan H, Adams L, deBlois D, Schwartz SM
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Submission date Apr 09, 2007
Last update date Dec 06, 2012
Contact name Lynn M Amon
E-mail(s) lynn.amon@cidresearch.org
Organization name Fred Hutchinson Cancer Research Center
Department Division of Public Health Sciences
Lab Computation Biology Program
Street address 1100 Fairview, M1-C108
City Seattle
State/province WA
ZIP/Postal code 98109-1024
Country USA
 
Platforms (1)
GPL890 Agilent-011868 Rat Oligo Microarray G4130A (Feature Number version)
Samples (58)
GSM181253 cy5:SHR control, biological rep 1r; cy3:pool of 6 WKY control rats
GSM181254 cy3:SHR control, biological rep 1g; cy5:pool of 6 WKY control rats
GSM181255 cy5:SHR control, biological rep 2r; cy3:pool of 6 WKY control rats
Relations
BioProject PRJNA100297

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE7483_RAW.tar 292.7 Mb (http)(custom) TAR (of TXT)

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