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Non-Neoplastic Digestive System Disorder

MedGen UID:
233773
Concept ID:
C1335011
Disease or Syndrome
Synonyms: Non-Neoplastic Gastrointestinal Disorder; Non-Neoplastic Gastrointestinal System Disorder

Definition

A non-neoplastic disorder that affects the gastrointestinal tract, anus, liver, biliary system, and pancreas. Representative examples include infections, ulcers, cirrhosis, and diverticulosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Digestive System Disorder

Professional guidelines

PubMed

Lira-Treviño A, Carranza Mendoza IG, Borbolla Arizti JP, Soriano-Ríos A, Uscanga-Domínguez L, Peláez-Luna M
Rev Gastroenterol Mex (Engl Ed) 2022 Apr-Jun;87(2):188-197. Epub 2022 May 21 doi: 10.1016/j.rgmxen.2022.05.002. PMID: 35610168
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Schmocker RK, Lidor AO
Surg Clin North Am 2017 Apr;97(2):387-403. doi: 10.1016/j.suc.2016.11.011. PMID: 28325193

Recent clinical studies

Etiology

Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
Repici A, Spadaccini M, Antonelli G, Correale L, Maselli R, Galtieri PA, Pellegatta G, Capogreco A, Milluzzo SM, Lollo G, Di Paolo D, Badalamenti M, Ferrara E, Fugazza A, Carrara S, Anderloni A, Rondonotti E, Amato A, De Gottardi A, Spada C, Radaelli F, Savevski V, Wallace MB, Sharma P, Rösch T, Hassan C
Gut 2022 Apr;71(4):757-765. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2021-324471. PMID: 34187845
Kővári B, Kim BH, Lauwers GY
Histopathology 2021 Jan;78(1):106-124. doi: 10.1111/his.14275. PMID: 33382489
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Bartel MJ, Picco MF, Wallace MB
Gastrointest Endosc Clin N Am 2015 Apr;25(2):243-60. doi: 10.1016/j.giec.2014.11.010. PMID: 25839685

Diagnosis

Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
Shaukat A, Lichtenstein DR, Somers SC, Chung DC, Perdue DG, Gopal M, Colucci DR, Phillips SA, Marka NA, Church TR, Brugge WR; SKOUT™ Registration Study Team
Gastroenterology 2022 Sep;163(3):732-741. Epub 2022 May 25 doi: 10.1053/j.gastro.2022.05.028. PMID: 35643173
Repici A, Spadaccini M, Antonelli G, Correale L, Maselli R, Galtieri PA, Pellegatta G, Capogreco A, Milluzzo SM, Lollo G, Di Paolo D, Badalamenti M, Ferrara E, Fugazza A, Carrara S, Anderloni A, Rondonotti E, Amato A, De Gottardi A, Spada C, Radaelli F, Savevski V, Wallace MB, Sharma P, Rösch T, Hassan C
Gut 2022 Apr;71(4):757-765. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2021-324471. PMID: 34187845
Bartel MJ, Picco MF, Wallace MB
Gastrointest Endosc Clin N Am 2015 Apr;25(2):243-60. doi: 10.1016/j.giec.2014.11.010. PMID: 25839685

Therapy

Haycock PC, Borges MC, Burrows K, Lemaitre RN, Burgess S, Khankari NK, Tsilidis KK, Gaunt TR, Hemani G, Zheng J, Truong T, Birmann BM, OMara T, Spurdle AB, Iles MM, Law MH, Slager SL, Saberi Hosnijeh F, Mariosa D, Cotterchio M, Cerhan JR, Peters U, Enroth S, Gharahkhani P, Le Marchand L, Williams AC, Block RC; ACCC; CCFR-CORECT-GECCO; EPITHYR; InterLymph; MMAC; ECAC; ILCCO; PRACTICAL Consortium; PanScan; PanC4, Amos CI, Hung RJ, Zheng W, Gunter MJ, Smith GD, Relton C, Martin RM; Fatty Acids in Cancer Mendelian Randomization Collaboration
EBioMedicine 2023 May;91:104510. Epub 2023 Apr 20 doi: 10.1016/j.ebiom.2023.104510. PMID: 37086649Free PMC Article
Shaukat A, Lichtenstein DR, Somers SC, Chung DC, Perdue DG, Gopal M, Colucci DR, Phillips SA, Marka NA, Church TR, Brugge WR; SKOUT™ Registration Study Team
Gastroenterology 2022 Sep;163(3):732-741. Epub 2022 May 25 doi: 10.1053/j.gastro.2022.05.028. PMID: 35643173
Repici A, Spadaccini M, Antonelli G, Correale L, Maselli R, Galtieri PA, Pellegatta G, Capogreco A, Milluzzo SM, Lollo G, Di Paolo D, Badalamenti M, Ferrara E, Fugazza A, Carrara S, Anderloni A, Rondonotti E, Amato A, De Gottardi A, Spada C, Radaelli F, Savevski V, Wallace MB, Sharma P, Rösch T, Hassan C
Gut 2022 Apr;71(4):757-765. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2021-324471. PMID: 34187845
Repici A, Badalamenti M, Maselli R, Correale L, Radaelli F, Rondonotti E, Ferrara E, Spadaccini M, Alkandari A, Fugazza A, Anderloni A, Galtieri PA, Pellegatta G, Carrara S, Di Leo M, Craviotto V, Lamonaca L, Lorenzetti R, Andrealli A, Antonelli G, Wallace M, Sharma P, Rosch T, Hassan C
Gastroenterology 2020 Aug;159(2):512-520.e7. Epub 2020 May 1 doi: 10.1053/j.gastro.2020.04.062. PMID: 32371116
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article

Prognosis

Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Senzolo M, Garcia-Tsao G, García-Pagán JC
J Hepatol 2021 Aug;75(2):442-453. Epub 2021 Apr 27 doi: 10.1016/j.jhep.2021.04.029. PMID: 33930474
Danford CJ, Lin SC, Wolf JL
Am J Gastroenterol 2019 Jun;114(6):867-873. doi: 10.14309/ajg.0000000000000167. PMID: 30829677
Asa SL, Mete O
Pathology 2018 Jan;50(1):111-118. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.003. PMID: 29132721
Gagnière J, Raisch J, Veziant J, Barnich N, Bonnet R, Buc E, Bringer MA, Pezet D, Bonnet M
World J Gastroenterol 2016 Jan 14;22(2):501-18. doi: 10.3748/wjg.v22.i2.501. PMID: 26811603Free PMC Article

Clinical prediction guides

Gioia S, Riggio O, Nardelli S, Ridola L, Marzano C
Dig Liver Dis 2023 Nov;55(11):1487-1495. Epub 2023 May 23 doi: 10.1016/j.dld.2023.05.007. PMID: 37230857
Chen Y, Li X, Sun R, Ji J, Yang F, Tian W, Ji W, Huang Q
Front Immunol 2022;13:1031539. Epub 2022 Nov 3 doi: 10.3389/fimmu.2022.1031539. PMID: 36405733Free PMC Article
Repici A, Spadaccini M, Antonelli G, Correale L, Maselli R, Galtieri PA, Pellegatta G, Capogreco A, Milluzzo SM, Lollo G, Di Paolo D, Badalamenti M, Ferrara E, Fugazza A, Carrara S, Anderloni A, Rondonotti E, Amato A, De Gottardi A, Spada C, Radaelli F, Savevski V, Wallace MB, Sharma P, Rösch T, Hassan C
Gut 2022 Apr;71(4):757-765. Epub 2021 Jun 29 doi: 10.1136/gutjnl-2021-324471. PMID: 34187845
Tabibian JH, Baron TH
Expert Rev Gastroenterol Hepatol 2018 Jul;12(7):693-703. Epub 2018 Jun 18 doi: 10.1080/17474124.2018.1483719. PMID: 29883229
Takahashi Y, Fukusato T
World J Gastroenterol 2014 Nov 14;20(42):15539-48. doi: 10.3748/wjg.v20.i42.15539. PMID: 25400438Free PMC Article

Recent systematic reviews

Wen J, Deng S, Bi Y, Qiao L, Xu H
Dig Liver Dis 2023 Jan;55(1):40-45. Epub 2022 Apr 18 doi: 10.1016/j.dld.2022.03.009. PMID: 35450814
Lord R, Burr NE, Mohammed N, Subramanian V
World J Gastroenterol 2018 Mar 14;24(10):1167-1180. doi: 10.3748/wjg.v24.i10.1167. PMID: 29563760Free PMC Article
Franceschet I, Zanetto A, Ferrarese A, Burra P, Senzolo M
World J Gastroenterol 2016 Dec 7;22(45):9909-9920. doi: 10.3748/wjg.v22.i45.9909. PMID: 28018098Free PMC Article
Parikh ND, Chaptini L, Njei B, Laine L
Endoscopy 2016 Aug;48(8):731-9. Epub 2016 May 25 doi: 10.1055/s-0042-107592. PMID: 27223636
Brown SR, Baraza W, Din S, Riley S
Cochrane Database Syst Rev 2016 Apr 7;4(4):CD006439. doi: 10.1002/14651858.CD006439.pub4. PMID: 27056645Free PMC Article

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