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Epithelial skin neoplasm

MedGen UID:
91063
Concept ID:
C0345976
Neoplastic Process
Synonyms: Epithelial neoplasm of skin; Epithelial Skin Neoplasm; epithelial skin neoplasm; Epithelial Skin Tumor; epithelial skin tumor; epithelial skin tumour; Skin Epithelium Neoplasm; skin epithelium neoplasm; Skin Epithelium Tumor; skin epithelium tumor; skin epithelium tumour; Tumor of surface epithelium; zone of skin epithelial neoplasm
SNOMED CT: Epithelial neoplasm of skin (254649008); Tumor of surface epithelium (254649008)
 
Monarch Initiative: MONDO:0021634

Definition

A benign, premalignant, or malignant neoplasm that arises from epithelial cells and involves the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelial skin neoplasm

Professional guidelines

PubMed

Kandolf L, Peris K, Malvehy J, Mosterd K, Heppt MV, Fargnoli MC, Berking C, Arenberger P, Bylaite-Bučinskiene M, Del Marmol V, Dirschka T, Dreno B, Forsea AM, Harwood CA, Hauschild A, Heerfordt IM, Kauffman R, Kelleners-Smeets N, Lallas A, Lebbe C, Leiter U, Longo C, Mijušković Ž, Pellacani G, Puig S, Saiag P, Šitum M, Stockfleth E, Salavastru C, Stratigos A, Zalaudek I, Garbe C; European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
J Eur Acad Dermatol Venereol 2024 Jun;38(6):1024-1047. Epub 2024 Mar 7 doi: 10.1111/jdv.19897. PMID: 38451047
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233Free PMC Article
Montone KT
Arch Pathol Lab Med 2015 Dec;139(12):1498-507. doi: 10.5858/arpa.2014-0383-RA. PMID: 26619022

Recent clinical studies

Etiology

Winge MCG, Kellman LN, Guo K, Tang JY, Swetter SM, Aasi SZ, Sarin KY, Chang ALS, Khavari PA
Nat Rev Cancer 2023 Jul;23(7):430-449. Epub 2023 Jun 7 doi: 10.1038/s41568-023-00583-5. PMID: 37286893
Chang MS, Azin M, Demehri S
Annu Rev Pathol 2022 Jan 24;17:101-119. doi: 10.1146/annurev-pathol-042320-120056. PMID: 35073167
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559

Diagnosis

Lezcano C, Jungbluth AA, Busam KJ
Am J Dermatopathol 2023 Nov 1;45(11):733-747. doi: 10.1097/DAD.0000000000002440. PMID: 37856737Free PMC Article
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
Schmults CD, Blitzblau R, Aasi SZ, Alam M, Andersen JS, Baumann BC, Bordeaux J, Chen PL, Chin R, Contreras CM, DiMaio D, Donigan JM, Farma JM, Ghosh K, Grekin RC, Harms K, Ho AL, Holder A, Lukens JN, Medina T, Nehal KS, Nghiem P, Park S, Patel T, Puzanov I, Scott J, Sekulic A, Shaha AR, Srivastava D, Stebbins W, Thomas V, Xu YG, McCullough B, Dwyer MA, Nguyen MQ
J Natl Compr Canc Netw 2021 Dec;19(12):1382-1394. doi: 10.6004/jnccn.2021.0059. PMID: 34902824
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807
Ratner D, Nelson BR, Brown MD, Johnson TM
J Am Acad Dermatol 1993 Aug;29(2 Pt 1):143-56. doi: 10.1016/0190-9622(93)70159-q. PMID: 8335732

Therapy

Kandolf L, Peris K, Malvehy J, Mosterd K, Heppt MV, Fargnoli MC, Berking C, Arenberger P, Bylaite-Bučinskiene M, Del Marmol V, Dirschka T, Dreno B, Forsea AM, Harwood CA, Hauschild A, Heerfordt IM, Kauffman R, Kelleners-Smeets N, Lallas A, Lebbe C, Leiter U, Longo C, Mijušković Ž, Pellacani G, Puig S, Saiag P, Šitum M, Stockfleth E, Salavastru C, Stratigos A, Zalaudek I, Garbe C; European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
J Eur Acad Dermatol Venereol 2024 Jun;38(6):1024-1047. Epub 2024 Mar 7 doi: 10.1111/jdv.19897. PMID: 38451047
Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C
Nature 2023 Aug;620(7973):402-408. Epub 2023 Aug 2 doi: 10.1038/s41586-023-06372-2. PMID: 37532929Free PMC Article
Chang MS, Azin M, Demehri S
Annu Rev Pathol 2022 Jan 24;17:101-119. doi: 10.1146/annurev-pathol-042320-120056. PMID: 35073167
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Tsao AS, Kim ES, Hong WK
CA Cancer J Clin 2004 May-Jun;54(3):150-80. doi: 10.3322/canjclin.54.3.150. PMID: 15195789

Prognosis

Liu H, Gao J, Feng M, Cheng J, Tang Y, Cao Q, Zhao Z, Meng Z, Zhang J, Zhang G, Zhang C, Zhao M, Yan Y, Wang Y, Xue R, Zhang N, Li H
Cancer Cell 2024 Jun 10;42(6):1067-1085.e11. Epub 2024 May 16 doi: 10.1016/j.ccell.2024.04.012. PMID: 38759655
Winge MCG, Kellman LN, Guo K, Tang JY, Swetter SM, Aasi SZ, Sarin KY, Chang ALS, Khavari PA
Nat Rev Cancer 2023 Jul;23(7):430-449. Epub 2023 Jun 7 doi: 10.1038/s41568-023-00583-5. PMID: 37286893
Zhang W, Xie X, Huang Z, Zhong X, Liu Y, Cheong KL, Zhou J, Tang S
Front Immunol 2022;13:919145. Epub 2022 Sep 23 doi: 10.3389/fimmu.2022.919145. PMID: 36211371Free PMC Article
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Clinical prediction guides

Liu H, Gao J, Feng M, Cheng J, Tang Y, Cao Q, Zhao Z, Meng Z, Zhang J, Zhang G, Zhang C, Zhao M, Yan Y, Wang Y, Xue R, Zhang N, Li H
Cancer Cell 2024 Jun 10;42(6):1067-1085.e11. Epub 2024 May 16 doi: 10.1016/j.ccell.2024.04.012. PMID: 38759655
Kandolf L, Peris K, Malvehy J, Mosterd K, Heppt MV, Fargnoli MC, Berking C, Arenberger P, Bylaite-Bučinskiene M, Del Marmol V, Dirschka T, Dreno B, Forsea AM, Harwood CA, Hauschild A, Heerfordt IM, Kauffman R, Kelleners-Smeets N, Lallas A, Lebbe C, Leiter U, Longo C, Mijušković Ž, Pellacani G, Puig S, Saiag P, Šitum M, Stockfleth E, Salavastru C, Stratigos A, Zalaudek I, Garbe C; European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes)
J Eur Acad Dermatol Venereol 2024 Jun;38(6):1024-1047. Epub 2024 Mar 7 doi: 10.1111/jdv.19897. PMID: 38451047
Rönsch H, Bauer A
Curr Probl Dermatol 2021;55:316-328. Epub 2021 Oct 25 doi: 10.1159/000517641. PMID: 34698024
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Larsen L, Chen HY, Saegusa J, Liu FT
J Dermatol Sci 2011 Nov;64(2):85-91. Epub 2011 Aug 11 doi: 10.1016/j.jdermsci.2011.07.008. PMID: 21889881Free PMC Article

Recent systematic reviews

Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Kampa F, Mitteldorf C
J Cutan Pathol 2021 Apr;48(4):495-510. Epub 2020 Nov 6 doi: 10.1111/cup.13894. PMID: 33047376
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451
López-Janeiro Á, Padilla-Ansala C, de Andrea CE, Hardisson D, Melero I
Mod Pathol 2020 Aug;33(8):1458-1465. Epub 2020 Apr 14 doi: 10.1038/s41379-020-0534-z. PMID: 32291396

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