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Epithelial skin neoplasm

MedGen UID:
91063
•Concept ID:
C0345976
•
Neoplastic Process
Synonyms: Epithelial neoplasm of skin; Epithelial Skin Neoplasm; epithelial skin neoplasm; Epithelial Skin Tumor; epithelial skin tumor; epithelial skin tumour; Skin Epithelium Neoplasm; skin epithelium neoplasm; Skin Epithelium Tumor; skin epithelium tumor; skin epithelium tumour; Tumor of surface epithelium; zone of skin epithelial neoplasm
SNOMED CT: Epithelial neoplasm of skin (254649008); Tumor of surface epithelium (254649008)
 
Monarch Initiative: MONDO:0021634

Definition

A benign, premalignant, or malignant neoplasm that arises from epithelial cells and involves the skin. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpithelial skin neoplasm

Professional guidelines

PubMed

Combinatorial Treatment with PARP and MAPK Inhibitors Overcomes Phenotype Switch-Driven Drug Resistance in Advanced Melanoma.
Ferretti LP, Böhi F, Leslie Pedrioli DM, Cheng PF, Ferrari E, Baumgaertner P, Alvarado-Diaz A, Sella F, Cereghetti A, Turko P, Wright RH, De Bock K, Speiser DE, Ferrari R, Levesque MP, Hottiger MO
Cancer Res 2023 Dec 1;83(23):3974-3988. doi: 10.1158/0008-5472.CAN-23-0485. PMID: 37729428
Current Diagnosis and Treatment Options for Cutaneous Adnexal Neoplasms with Follicular Differentiation.
Płachta I, Kleibert M, Czarnecka AM, Spałek M, Szumera-Ciećkiewicz A, Rutkowski P
Int J Mol Sci 2021 Apr 30;22(9) doi: 10.3390/ijms22094759. PMID: 33946233Free PMC Article
Clinical and biological determinants of melanoma progression: Should all be considered for clinical management?
Rowe CJ, Khosrotehrani K
Australas J Dermatol 2016 Aug;57(3):175-81. Epub 2015 May 25 doi: 10.1111/ajd.12348. PMID: 26010424

Recent clinical studies

Etiology

Advances in cutaneous squamous cell carcinoma.
Winge MCG, Kellman LN, Guo K, Tang JY, Swetter SM, Aasi SZ, Sarin KY, Chang ALS, Khavari PA
Nat Rev Cancer 2023 Jul;23(7):430-449. Epub 2023 Jun 7 doi: 10.1038/s41568-023-00583-5. PMID: 37286893
Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention.
Chang MS, Azin M, Demehri S
Annu Rev Pathol 2022 Jan 24;17:101-119. doi: 10.1146/annurev-pathol-042320-120056. PMID: 35073167
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
The low-risk papillomaviruses.
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Cubilla AL, Humphrey PA, Reuter VE, Ulbright TM
Eur Urol 2016 Jul;70(1):93-105. Epub 2016 Feb 28 doi: 10.1016/j.eururo.2016.02.029. PMID: 26935559

Diagnosis

The many faces of Atypical fibroxanthoma.
Agaimy A
Semin Diagn Pathol 2023 Jul;40(4):306-312. Epub 2023 Jun 23 doi: 10.1053/j.semdp.2023.06.001. PMID: 37438163
PRAME Expression in Cancer. A Systematic Immunohistochemical Study of >5800 Epithelial and Nonepithelial Tumors.
Kaczorowski M, Chłopek M, Kruczak A, Ryś J, Lasota J, Miettinen M
Am J Surg Pathol 2022 Nov 1;46(11):1467-1476. Epub 2022 Aug 16 doi: 10.1097/PAS.0000000000001944. PMID: 35973038Free PMC Article
NCCN Guidelines® Insights: Squamous Cell Skin Cancer, Version 1.2022.
Schmults CD, Blitzblau R, Aasi SZ, Alam M, Andersen JS, Baumann BC, Bordeaux J, Chen PL, Chin R, Contreras CM, DiMaio D, Donigan JM, Farma JM, Ghosh K, Grekin RC, Harms K, Ho AL, Holder A, Lukens JN, Medina T, Nehal KS, Nghiem P, Park S, Patel T, Puzanov I, Scott J, Sekulic A, Shaha AR, Srivastava D, Stebbins W, Thomas V, Xu YG, McCullough B, Dwyer MA, Nguyen MQ
J Natl Compr Canc Netw 2021 Dec;19(12):1382-1394. doi: 10.6004/jnccn.2021.0059. PMID: 34902824
Merkel cell carcinoma.
Wong HH, Wang J
Arch Pathol Lab Med 2010 Nov;134(11):1711-6. doi: 10.5858/2009-0165-RSR2.1. PMID: 21043828
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Therapy

Pharmacological targeting of netrin-1 inhibits EMT in cancer.
Lengrand J, Pastushenko I, Vanuytven S, Song Y, Venet D, Sarate RM, Bellina M, Moers V, Boinet A, Sifrim A, Rama N, Ducarouge B, Van Herck J, Dubois C, Scozzaro S, Lemaire S, Gieskes S, Bonni S, Collin A, Braissand N, Allard J, Zindy E, Decaestecker C, Sotiriou C, Salmon I, Mehlen P, Voet T, Bernet A, Blanpain C
Nature 2023 Aug;620(7973):402-408. Epub 2023 Aug 2 doi: 10.1038/s41586-023-06372-2. PMID: 37532929Free PMC Article
Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.
Gershenson DM, Miller A, Brady WE, Paul J, Carty K, Rodgers W, Millan D, Coleman RL, Moore KN, Banerjee S, Connolly K, Secord AA, O'Malley DM, Dorigo O, Gaillard S, Gabra H, Slomovitz B, Hanjani P, Farley J, Churchman M, Ewing A, Hollis RL, Herrington CS, Huang HQ, Wenzel L, Gourley C
Lancet 2022 Feb 5;399(10324):541-553. doi: 10.1016/S0140-6736(21)02175-9. PMID: 35123694Free PMC Article
Cutaneous Squamous Cell Carcinoma: The Frontier of Cancer Immunoprevention.
Chang MS, Azin M, Demehri S
Annu Rev Pathol 2022 Jan 24;17:101-119. doi: 10.1146/annurev-pathol-042320-120056. PMID: 35073167
Epithelial-to-mesenchymal-like transition events in melanoma.
Pedri D, Karras P, Landeloos E, Marine JC, Rambow F
FEBS J 2022 Mar;289(5):1352-1368. Epub 2021 May 30 doi: 10.1111/febs.16021. PMID: 33999497
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665

Prognosis

Advances in cutaneous squamous cell carcinoma.
Winge MCG, Kellman LN, Guo K, Tang JY, Swetter SM, Aasi SZ, Sarin KY, Chang ALS, Khavari PA
Nat Rev Cancer 2023 Jul;23(7):430-449. Epub 2023 Jun 7 doi: 10.1038/s41568-023-00583-5. PMID: 37286893
The integration of single-cell sequencing, TCGA, and GEO data analysis revealed that PRRT3-AS1 is a biomarker and therapeutic target of SKCM.
Zhang W, Xie X, Huang Z, Zhong X, Liu Y, Cheong KL, Zhou J, Tang S
Front Immunol 2022;13:919145. Epub 2022 Sep 23 doi: 10.3389/fimmu.2022.919145. PMID: 36211371Free PMC Article
Epithelial-to-mesenchymal-like transition events in melanoma.
Pedri D, Karras P, Landeloos E, Marine JC, Rambow F
FEBS J 2022 Mar;289(5):1352-1368. Epub 2021 May 30 doi: 10.1111/febs.16021. PMID: 33999497
Field cancerization: Definition, epidemiology, risk factors, and outcomes.
Willenbrink TJ, Ruiz ES, Cornejo CM, Schmults CD, Arron ST, Jambusaria-Pahlajani A
J Am Acad Dermatol 2020 Sep;83(3):709-717. Epub 2020 May 7 doi: 10.1016/j.jaad.2020.03.126. PMID: 32387665
Immunohistochemical characteristics of melanoma.
Ohsie SJ, Sarantopoulos GP, Cochran AJ, Binder SW
J Cutan Pathol 2008 May;35(5):433-44. doi: 10.1111/j.1600-0560.2007.00891.x. PMID: 18399807

Clinical prediction guides

The Preventive Value of Sun Protection.
Rönsch H, Bauer A
Curr Probl Dermatol 2021;55:316-328. Epub 2021 Oct 25 doi: 10.1159/000517641. PMID: 34698024
Noninvasive diagnosis in dermatology.
Welzel J, Schuh S
J Dtsch Dermatol Ges 2017 Oct;15(10):999-1016. doi: 10.1111/ddg.13347. PMID: 28976087
Syringometaplasia: variants and underlying mechanisms.
Abbas O, Bhawan J
Int J Dermatol 2016 Feb;55(2):142-8. Epub 2015 Oct 13 doi: 10.1111/ijd.13040. PMID: 26460811
Pleomorphic dermal neoplasms: a review.
Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694
Galectin-3 and the skin.
Larsen L, Chen HY, Saegusa J, Liu FT
J Dermatol Sci 2011 Nov;64(2):85-91. Epub 2011 Aug 11 doi: 10.1016/j.jdermsci.2011.07.008. PMID: 21889881Free PMC Article

Recent systematic reviews

Clinicopathological Analysis of Actinic Cheilitis: A Systematic Review with Meta-analyses.
Carneiro MC, Quenta-Huayhua MG, Peralta-Mamani M, Honório HM, Santos PSDS, Rubira-Bullen IRF, Rubira CMF
Head Neck Pathol 2023 Sep;17(3):708-721. Epub 2023 Mar 9 doi: 10.1007/s12105-023-01543-z. PMID: 36892803Free PMC Article
Basal cell carcinosarcoma: a systematic review and reappraisal of its challenges and the role of Mohs surgery.
Born LJ, Khachemoune A
Arch Dermatol Res 2023 Oct;315(8):2195-2205. Epub 2023 Feb 15 doi: 10.1007/s00403-023-02551-3. PMID: 36790451
Immunohistochemical Characteristics of Atypical Fibroxanthoma and Pleomorphic Dermal Sarcoma: A Systematic Review and Meta-Analysis.
Ørholt M, Abebe K, Aaberg F, Rasmussen LE, Daugaard S, Loya AC, Herly M, Vester-Glowinski PV
Am J Dermatopathol 2022 Dec 1;44(12):913-920. doi: 10.1097/DAD.0000000000002305. PMID: 36395448
A review of CD30 expression in cutaneous neoplasms.
Kampa F, Mitteldorf C
J Cutan Pathol 2021 Apr;48(4):495-510. Epub 2020 Nov 6 doi: 10.1111/cup.13894. PMID: 33047376
Novel approaches for managing aged skin and nonmelanoma skin cancer.
Todorova K, Mandinova A
Adv Drug Deliv Rev 2020 Jan 1;153:18-27. Epub 2020 Jun 8 doi: 10.1016/j.addr.2020.06.004. PMID: 32526451

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