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Reproductive system cancer

MedGen UID:
233668
•Concept ID:
C1334618
•
Neoplastic Process
Synonyms: cancer of reproductive organ; cancer of reproductive system; malignant neoplasm of reproductive organ; malignant neoplasm of reproductive system; malignant reproductive organ neoplasm; Malignant Reproductive System Neoplasm; malignant reproductive system neoplasm; reproductive organ cancer; reproductive system cancer
 
Monarch Initiative: MONDO:0002149

Definition

A primary or metastatic malignant neoplasm that affects the male or female reproductive system. Representative examples include prostate carcinoma, penile carcinoma, testicular seminoma, testicular embryonal carcinoma, endometrial carcinoma, cervical carcinoma, ovarian carcinoma, and uterine corpus leiomyosarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReproductive system cancer

Professional guidelines

PubMed

Recommendations from the 2023 international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE; International PCOS Network
Eur J Endocrinol 2023 Aug 2;189(2):G43-G64. doi: 10.1093/ejendo/lvad096. PMID: 37580861
Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome.
Teede HJ, Tay CT, Laven JJE, Dokras A, Moran LJ, Piltonen TT, Costello MF, Boivin J, Redman LM, Boyle JA, Norman RJ, Mousa A, Joham AE
J Clin Endocrinol Metab 2023 Sep 18;108(10):2447-2469. doi: 10.1210/clinem/dgad463. PMID: 37580314Free PMC Article
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.
Brioude F, Kalish JM, Mussa A, Foster AC, Bliek J, Ferrero GB, Boonen SE, Cole T, Baker R, Bertoletti M, Cocchi G, Coze C, De Pellegrin M, Hussain K, Ibrahim A, Kilby MD, Krajewska-Walasek M, Kratz CP, Ladusans EJ, Lapunzina P, Le Bouc Y, Maas SM, Macdonald F, Õunap K, Peruzzi L, Rossignol S, Russo S, Shipster C, Skórka A, Tatton-Brown K, Tenorio J, Tortora C, Grønskov K, Netchine I, Hennekam RC, Prawitt D, Tümer Z, Eggermann T, Mackay DJG, Riccio A, Maher ER
Nat Rev Endocrinol 2018 Apr;14(4):229-249. Epub 2018 Jan 29 doi: 10.1038/nrendo.2017.166. PMID: 29377879Free PMC Article

Recent clinical studies

Etiology

Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer Med 2023 Aug;12(15):16337-16358. Epub 2023 Jun 30 doi: 10.1002/cam4.6256. PMID: 37387559Free PMC Article
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta-Analyses.
Meng R, Chen LR, Zhang ML, Cai WK, Yin SJ, Fan YX, Zhou T, Huang YH, He GH
J Clin Pharmacol 2023 Jan;63(1):7-20. Epub 2022 Sep 22 doi: 10.1002/jcph.2147. PMID: 36039014
Regulation of the aryl hydrocarbon receptor in cancer and cancer stem cells of gynecological malignancies: An update on signaling pathways.
Therachiyil L, Hussein OJ, Uddin S, Korashy HM
Semin Cancer Biol 2022 Nov;86(Pt 3):1186-1202. Epub 2022 Oct 15 doi: 10.1016/j.semcancer.2022.10.003. PMID: 36252938
Meta-analysis of XRCC1 polymorphism and risk of female reproductive system cancer.
Yang NN, Huang YF, Sun J, Chen Y, Tang ZM, Jiang JF
Oncotarget 2017 Apr 25;8(17):28455-28462. doi: 10.18632/oncotarget.16090. PMID: 28415705Free PMC Article
Oral contraceptives and reproductive system cancer.
Deligeoroglou E, Michailidis E, Creatsas G
Ann N Y Acad Sci 2003 Nov;997:199-208. doi: 10.1196/annals.1290.023. PMID: 14644827

Diagnosis

Prognostic value of insulin resistance in patients with female reproductive system malignancies: A multicenter cohort study.
Liu XY, Zhang Q, Zhang X, Ge YZ, Ruan GT, Xie HL, Liu T, Song MM, Deng L, Shi HP
Immun Inflamm Dis 2023 Dec;11(12):e1107. doi: 10.1002/iid3.1107. PMID: 38156375Free PMC Article
Potential serum metabolites and long-chain noncoding RNA biomarkers for endometrial cancer tissue.
Hao C, Lin S, Liu P, Liang W, Li Z, Li Y
J Obstet Gynaecol Res 2023 Feb;49(2):725-743. Epub 2022 Dec 12 doi: 10.1111/jog.15494. PMID: 36510632
CA125 as a predictor of endometrial cancer lymphovascular space invasion and lymph node metastasis for risk stratification in the preoperative setting.
Shawn LyBarger K, Miller HA, Frieboes HB
Sci Rep 2022 Nov 17;12(1):19783. doi: 10.1038/s41598-022-22026-1. PMID: 36396713Free PMC Article
Work with cancer or stop working after diagnosis? Variables affecting the decision.
Gragnano A, Miglioretti M, Magon G, Pravettoni G
Work 2021;70(1):177-185. doi: 10.3233/WOR-213563. PMID: 34511522
Oral contraceptives and reproductive system cancer.
Deligeoroglou E, Michailidis E, Creatsas G
Ann N Y Acad Sci 2003 Nov;997:199-208. doi: 10.1196/annals.1290.023. PMID: 14644827

Therapy

Exposure to di-2-ethylhexyl phthalate (DEHP) increases the risk of cancer.
Yang L, Liu X, Peng Z, Liu Z, Song P, Zhou J, Ma K, Yu Y, Dong Q
BMC Public Health 2024 Feb 10;24(1):430. doi: 10.1186/s12889-024-17801-w. PMID: 38341560Free PMC Article
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer Med 2023 Aug;12(15):16337-16358. Epub 2023 Jun 30 doi: 10.1002/cam4.6256. PMID: 37387559Free PMC Article
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta-Analyses.
Meng R, Chen LR, Zhang ML, Cai WK, Yin SJ, Fan YX, Zhou T, Huang YH, He GH
J Clin Pharmacol 2023 Jan;63(1):7-20. Epub 2022 Sep 22 doi: 10.1002/jcph.2147. PMID: 36039014
Oral contraceptives and reproductive system cancer.
Deligeoroglou E, Michailidis E, Creatsas G
Ann N Y Acad Sci 2003 Nov;997:199-208. doi: 10.1196/annals.1290.023. PMID: 14644827
Oral contraceptives and reproductive system cancer. Benefits and risks.
Williams JK
J Reprod Med 1991 Mar;36(3 Suppl):247-52. PMID: 2046078

Prognosis

Prognostic value of insulin resistance in patients with female reproductive system malignancies: A multicenter cohort study.
Liu XY, Zhang Q, Zhang X, Ge YZ, Ruan GT, Xie HL, Liu T, Song MM, Deng L, Shi HP
Immun Inflamm Dis 2023 Dec;11(12):e1107. doi: 10.1002/iid3.1107. PMID: 38156375Free PMC Article
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer Med 2023 Aug;12(15):16337-16358. Epub 2023 Jun 30 doi: 10.1002/cam4.6256. PMID: 37387559Free PMC Article
Molecular Regulation of Androgen Receptors in Major Female Reproductive System Cancers.
Wu S, Yu K, Lian Z, Deng S
Int J Mol Sci 2022 Jul 8;23(14) doi: 10.3390/ijms23147556. PMID: 35886904Free PMC Article
Work with cancer or stop working after diagnosis? Variables affecting the decision.
Gragnano A, Miglioretti M, Magon G, Pravettoni G
Work 2021;70(1):177-185. doi: 10.3233/WOR-213563. PMID: 34511522
Oral contraceptives and reproductive system cancer.
Deligeoroglou E, Michailidis E, Creatsas G
Ann N Y Acad Sci 2003 Nov;997:199-208. doi: 10.1196/annals.1290.023. PMID: 14644827

Clinical prediction guides

Prognostic value of insulin resistance in patients with female reproductive system malignancies: A multicenter cohort study.
Liu XY, Zhang Q, Zhang X, Ge YZ, Ruan GT, Xie HL, Liu T, Song MM, Deng L, Shi HP
Immun Inflamm Dis 2023 Dec;11(12):e1107. doi: 10.1002/iid3.1107. PMID: 38156375Free PMC Article
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer Med 2023 Aug;12(15):16337-16358. Epub 2023 Jun 30 doi: 10.1002/cam4.6256. PMID: 37387559Free PMC Article
Effectiveness and Safety of Histamine H2 Receptor Antagonists: An Umbrella Review of Meta-Analyses.
Meng R, Chen LR, Zhang ML, Cai WK, Yin SJ, Fan YX, Zhou T, Huang YH, He GH
J Clin Pharmacol 2023 Jan;63(1):7-20. Epub 2022 Sep 22 doi: 10.1002/jcph.2147. PMID: 36039014
Work with cancer or stop working after diagnosis? Variables affecting the decision.
Gragnano A, Miglioretti M, Magon G, Pravettoni G
Work 2021;70(1):177-185. doi: 10.3233/WOR-213563. PMID: 34511522
Temporal Trends of Common Female Malignances on Breast, Cervical, and Ovarian Cancer Mortality in Japan, Republic of Korea, and Singapore: Application of the Age-Period-Cohort Model.
Wang J, Lv H, Xue Z, Wang L, Bai Z
Biomed Res Int 2018;2018:5307459. Epub 2018 Mar 21 doi: 10.1155/2018/5307459. PMID: 29750160Free PMC Article

Recent systematic reviews

The prognostic and clinicopathological significance of desmoglein 2 in human cancers: a systematic review and meta-analysis.
Wang J, Hao S, Gu J, Rudd SG, Wang Y
PeerJ 2022;10:e13141. Epub 2022 Mar 22 doi: 10.7717/peerj.13141. PMID: 35345582Free PMC Article

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