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Nevi and Melanomas

MedGen UID:
61679
•Concept ID:
C0206769
•
Neoplastic Process
Synonym: Melanomas and Nevi

Definition

A collective term for the various types of nevi and melanomas. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNevi and Melanomas

Professional guidelines

PubMed

Use of artificial intelligence in skin cancer diagnosis and management.
Wada M, Ge Z, Gilmore SJ, Mar VJ
Med J Aust 2020 Sep;213(6):256-259.e1. Epub 2020 Sep 6 doi: 10.5694/mja2.50759. PMID: 32892366
ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.
Pérez-Alea M, McGrail K, Sánchez-Redondo S, Ferrer B, Fournet G, Cortés J, Muñoz E, Hernandez-Losa J, Tenbaum S, Martin G, Costello R, Ceylan I, Garcia-Patos V, Recio JA
Oncogene 2017 Oct 12;36(41):5695-5708. Epub 2017 Jun 5 doi: 10.1038/onc.2017.160. PMID: 28581514

Recent clinical studies

Etiology

Risk factors for the development of Spitz neoplasms.
Benton S, Roth A, Khan AU, Zhao J, Kim D, Compres EV, Wagner AM, Kruse LL, Zhang B, Gerami P
Pediatr Dermatol 2022 Mar;39(2):220-225. Epub 2022 Feb 21 doi: 10.1111/pde.14957. PMID: 35187702Free PMC Article
Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?
Urso C
Am J Dermatopathol 2019 Sep;41(9):623-629. doi: 10.1097/DAD.0000000000001341. PMID: 31433323
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Dysplastic nevi.
Farber MJ, Heilman ER, Friedman RJ
Dermatol Clin 2012 Jul;30(3):389-404. Epub 2012 Jun 8 doi: 10.1016/j.det.2012.04.004. PMID: 22800547
Growth factor and cytogenetic abnormalities in cultured nevi and malignant melanomas.
Richmond A, Fine R, Murray D, Lawson DH, Priest JH
J Invest Dermatol 1986 Mar;86(3):295-302. doi: 10.1111/1523-1747.ep12285452. PMID: 3745955

Diagnosis

Risk factors for the development of Spitz neoplasms.
Benton S, Roth A, Khan AU, Zhao J, Kim D, Compres EV, Wagner AM, Kruse LL, Zhang B, Gerami P
Pediatr Dermatol 2022 Mar;39(2):220-225. Epub 2022 Feb 21 doi: 10.1111/pde.14957. PMID: 35187702Free PMC Article
Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?
Urso C
Am J Dermatopathol 2019 Sep;41(9):623-629. doi: 10.1097/DAD.0000000000001341. PMID: 31433323
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Melanocytic nevi and non-neoplastic hyperpigmentations.
Clemente C
Pathologica 2017 Jun;109(2):67-96. PMID: 28748967
Dysplastic nevi.
Farber MJ, Heilman ER, Friedman RJ
Dermatol Clin 2012 Jul;30(3):389-404. Epub 2012 Jun 8 doi: 10.1016/j.det.2012.04.004. PMID: 22800547

Therapy

Analyzing the Spatial Randomness in the Distribution of Acquired Melanocytic Neoplasms.
Chousakos E, Kose K, Kurtansky NR, Dusza SW, Halpern AC, Marghoob AA
J Invest Dermatol 2022 Dec;142(12):3274-3281. Epub 2022 Jul 14 doi: 10.1016/j.jid.2022.06.011. PMID: 35841946Free PMC Article
Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection.
Young AR, Claveau J, Rossi AB
J Am Acad Dermatol 2017 Mar;76(3S1):S100-S109. Epub 2016 Dec 27 doi: 10.1016/j.jaad.2016.09.038. PMID: 28038885
p15 Expression Differentiates Nevus from Melanoma.
Taylor LA, O'Day C, Dentchev T, Hood K, Chu EY, Ridky TW, Seykora JT
Am J Pathol 2016 Dec;186(12):3094-3099. Epub 2016 Nov 14 doi: 10.1016/j.ajpath.2016.08.009. PMID: 27855847Free PMC Article
Dermoscopy in the era of dermato-oncology: from bed to bench side and retour.
Woltsche N, Schwab C, Deinlein T, Hofmann-Wellenhof R, Zalaudek I
Expert Rev Anticancer Ther 2016 May;16(5):531-41. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168700. PMID: 26999650
High frequency of PTEN mutations in nevi and melanomas from xeroderma pigmentosum patients.
Masaki T, Wang Y, DiGiovanna JJ, Khan SG, Raffeld M, Beltaifa S, Hornyak TJ, Darling TN, Lee CC, Kraemer KH
Pigment Cell Melanoma Res 2014 May;27(3):454-64. Epub 2014 Feb 21 doi: 10.1111/pcmr.12226. PMID: 24483290Free PMC Article

Prognosis

Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples.
Chrysanthou E, Sehovic E, Ostano P, Chiorino G
Cells 2022 Mar 24;11(7) doi: 10.3390/cells11071099. PMID: 35406661Free PMC Article
Distinct MAPK and PI3K pathway mutations in different melanoma types in Taiwanese individuals.
Gao HW, Tsai WC, Perng CL, Wang WM, Chiang CP
Eur J Dermatol 2018 Aug 1;28(4):509-518. doi: 10.1684/ejd.2018.3359. PMID: 30325319
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Melanocytic nevi and non-neoplastic hyperpigmentations.
Clemente C
Pathologica 2017 Jun;109(2):67-96. PMID: 28748967
Progesterone and estrogen receptors in conjunctival melanoma and nevi.
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw-Haedrich C
Graefes Arch Clin Exp Ophthalmol 2014 Feb;252(2):359-65. Epub 2013 Nov 26 doi: 10.1007/s00417-013-2523-0. PMID: 24276560

Clinical prediction guides

Analyzing the Spatial Randomness in the Distribution of Acquired Melanocytic Neoplasms.
Chousakos E, Kose K, Kurtansky NR, Dusza SW, Halpern AC, Marghoob AA
J Invest Dermatol 2022 Dec;142(12):3274-3281. Epub 2022 Jul 14 doi: 10.1016/j.jid.2022.06.011. PMID: 35841946Free PMC Article
BRAF(V600E) induces reversible mitotic arrest in human melanocytes via microrna-mediated suppression of AURKB.
McNeal AS, Belote RL, Zeng H, Urquijo M, Barker K, Torres R, Curtin M, Shain AH, Andtbacka RH, Holmen S, Lum DH, McCalmont TH, VanBrocklin MW, Grossman D, Wei ML, Lang UE, Judson-Torres RL
Elife 2021 Nov 23;10 doi: 10.7554/eLife.70385. PMID: 34812139Free PMC Article
Differentiation of combined nevi and melanomas: Case-control study with comparative analysis of dermoscopic features.
Schweizer A, Fink C, Bertlich I, Toberer F, Mitteldorf C, Stolz W, Enk A, Kilian S, Haenssle HA
J Dtsch Dermatol Ges 2020 Feb;18(2):111-118. Epub 2020 Jan 17 doi: 10.1111/ddg.14019. PMID: 31951105
Quantification of microRNA-21 and microRNA-125b in melanoma tissue.
Wandler A, Riber-Hansen R, Hager H, Hamilton-Dutoit SJ, Schmidt H, Nielsen BS, Stougaard M, Steiniche T
Melanoma Res 2017 Oct;27(5):417-428. doi: 10.1097/CMR.0000000000000374. PMID: 28614272
Progesterone and estrogen receptors in conjunctival melanoma and nevi.
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw-Haedrich C
Graefes Arch Clin Exp Ophthalmol 2014 Feb;252(2):359-65. Epub 2013 Nov 26 doi: 10.1007/s00417-013-2523-0. PMID: 24276560

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