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Nevi and Melanomas

MedGen UID:
61679
•Concept ID:
C0206769
•
Neoplastic Process
Synonym: Melanomas and Nevi

Definition

A collective term for the various types of nevi and melanomas. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNevi and Melanomas

Professional guidelines

PubMed

Use of artificial intelligence in skin cancer diagnosis and management.
Wada M, Ge Z, Gilmore SJ, Mar VJ
Med J Aust 2020 Sep;213(6):256-259.e1. Epub 2020 Sep 6 doi: 10.5694/mja2.50759. PMID: 32892366
ALDH1A3 is epigenetically regulated during melanocyte transformation and is a target for melanoma treatment.
Pérez-Alea M, McGrail K, Sánchez-Redondo S, Ferrer B, Fournet G, Cortés J, Muñoz E, Hernandez-Losa J, Tenbaum S, Martin G, Costello R, Ceylan I, Garcia-Patos V, Recio JA
Oncogene 2017 Oct 12;36(41):5695-5708. Epub 2017 Jun 5 doi: 10.1038/onc.2017.160. PMID: 28581514

Recent clinical studies

Etiology

Left-sided excess in the laterality of cutaneous melanocytic nevi and melanomas.
Bauer-Büntzel C, Kück F, Kretschmer L
J Dtsch Dermatol Ges 2022 Oct;20(10):1315-1323. Epub 2022 Oct 9 doi: 10.1111/ddg.14864. PMID: 36210057
Differentiation of combined nevi and melanomas: Case-control study with comparative analysis of dermoscopic features.
Schweizer A, Fink C, Bertlich I, Toberer F, Mitteldorf C, Stolz W, Enk A, Kilian S, Haenssle HA
J Dtsch Dermatol Ges 2020 Feb;18(2):111-118. Epub 2020 Jan 17 doi: 10.1111/ddg.14019. PMID: 31951105
Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?
Urso C
Am J Dermatopathol 2019 Sep;41(9):623-629. doi: 10.1097/DAD.0000000000001341. PMID: 31433323
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Dysplastic nevi.
Farber MJ, Heilman ER, Friedman RJ
Dermatol Clin 2012 Jul;30(3):389-404. Epub 2012 Jun 8 doi: 10.1016/j.det.2012.04.004. PMID: 22800547

Diagnosis

Melanocytic Skin Neoplasms: What Lesson From Genomic Aberrations?
Urso C
Am J Dermatopathol 2019 Sep;41(9):623-629. doi: 10.1097/DAD.0000000000001341. PMID: 31433323
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Nuclear and cytoplasmic features in the diagnosis of Clark's nevi.
Valdebran M, Bandino J, Elbendary A, Gad A, Arudra KC, de Feraudy S, Elston DM
J Cutan Pathol 2018 Mar;45(3):204-207. Epub 2017 Dec 28 doi: 10.1111/cup.13085. PMID: 29193203Free PMC Article
Melanocytic nevi and non-neoplastic hyperpigmentations.
Clemente C
Pathologica 2017 Jun;109(2):67-96. PMID: 28748967
Dysplastic nevi.
Farber MJ, Heilman ER, Friedman RJ
Dermatol Clin 2012 Jul;30(3):389-404. Epub 2012 Jun 8 doi: 10.1016/j.det.2012.04.004. PMID: 22800547

Therapy

Analyzing the Spatial Randomness in the Distribution of Acquired Melanocytic Neoplasms.
Chousakos E, Kose K, Kurtansky NR, Dusza SW, Halpern AC, Marghoob AA
J Invest Dermatol 2022 Dec;142(12):3274-3281. Epub 2022 Jul 14 doi: 10.1016/j.jid.2022.06.011. PMID: 35841946Free PMC Article
Regulatory T Cells Play an Important Role in the Prevention of Murine Melanocytic Nevi and Melanomas.
Nasti TH, Yusuf N, Sherwani MA, Athar M, Timares L, Elmets CA
Cancer Prev Res (Phila) 2021 Feb;14(2):165-174. Epub 2020 Nov 4 doi: 10.1158/1940-6207.CAPR-20-0360. PMID: 33148679Free PMC Article
Nuclear and cytoplasmic features in the diagnosis of Clark's nevi.
Valdebran M, Bandino J, Elbendary A, Gad A, Arudra KC, de Feraudy S, Elston DM
J Cutan Pathol 2018 Mar;45(3):204-207. Epub 2017 Dec 28 doi: 10.1111/cup.13085. PMID: 29193203Free PMC Article
Ultraviolet radiation and the skin: Photobiology and sunscreen photoprotection.
Young AR, Claveau J, Rossi AB
J Am Acad Dermatol 2017 Mar;76(3S1):S100-S109. Epub 2016 Dec 27 doi: 10.1016/j.jaad.2016.09.038. PMID: 28038885
Dermoscopy in the era of dermato-oncology: from bed to bench side and retour.
Woltsche N, Schwab C, Deinlein T, Hofmann-Wellenhof R, Zalaudek I
Expert Rev Anticancer Ther 2016 May;16(5):531-41. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168700. PMID: 26999650

Prognosis

Comprehensive Gene Expression Analysis to Identify Differences and Similarities between Sex- and Stage-Stratified Melanoma Samples.
Chrysanthou E, Sehovic E, Ostano P, Chiorino G
Cells 2022 Mar 24;11(7) doi: 10.3390/cells11071099. PMID: 35406661Free PMC Article
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Melanocytic nevi and non-neoplastic hyperpigmentations.
Clemente C
Pathologica 2017 Jun;109(2):67-96. PMID: 28748967
Progesterone and estrogen receptors in conjunctival melanoma and nevi.
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw-Haedrich C
Graefes Arch Clin Exp Ophthalmol 2014 Feb;252(2):359-65. Epub 2013 Nov 26 doi: 10.1007/s00417-013-2523-0. PMID: 24276560
Size overlap between benign melanocytic choroidal nevi and choroidal malignant melanomas.
Augsburger JJ, Corrêa ZM, Trichopoulos N, Shaikh A
Invest Ophthalmol Vis Sci 2008 Jul;49(7):2823-8. Epub 2008 Apr 11 doi: 10.1167/iovs.07-1603. PMID: 18408179

Clinical prediction guides

Analyzing the Spatial Randomness in the Distribution of Acquired Melanocytic Neoplasms.
Chousakos E, Kose K, Kurtansky NR, Dusza SW, Halpern AC, Marghoob AA
J Invest Dermatol 2022 Dec;142(12):3274-3281. Epub 2022 Jul 14 doi: 10.1016/j.jid.2022.06.011. PMID: 35841946Free PMC Article
Differentiation of combined nevi and melanomas: Case-control study with comparative analysis of dermoscopic features.
Schweizer A, Fink C, Bertlich I, Toberer F, Mitteldorf C, Stolz W, Enk A, Kilian S, Haenssle HA
J Dtsch Dermatol Ges 2020 Feb;18(2):111-118. Epub 2020 Jan 17 doi: 10.1111/ddg.14019. PMID: 31951105
Nuclear and cytoplasmic features in the diagnosis of Clark's nevi.
Valdebran M, Bandino J, Elbendary A, Gad A, Arudra KC, de Feraudy S, Elston DM
J Cutan Pathol 2018 Mar;45(3):204-207. Epub 2017 Dec 28 doi: 10.1111/cup.13085. PMID: 29193203Free PMC Article
Progesterone and estrogen receptors in conjunctival melanoma and nevi.
Bredow L, Stützel L, Böhringer D, Gundlach E, Reinhard T, Auw-Haedrich C
Graefes Arch Clin Exp Ophthalmol 2014 Feb;252(2):359-65. Epub 2013 Nov 26 doi: 10.1007/s00417-013-2523-0. PMID: 24276560
"White" network in Spitz nevi and early melanomas lacking significant pigmentation.
Zalaudek I, Kittler H, Hofmann-Wellenhof R, Kreusch J, Longo C, Malvehy J, Puig S, Moscarella E, Piana S, Massone C, Cota C, Ferrara G, Fleischer M, Argenziano G
J Am Acad Dermatol 2013 Jul;69(1):56-60. Epub 2013 Feb 12 doi: 10.1016/j.jaad.2012.12.974. PMID: 23415462

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