U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Non-Neoplastic Eye Disorder

MedGen UID:
235381
•Concept ID:
C1335009
•
Disease or Syndrome
Synonym: Non-Neoplastic Eye Disease

Definition

A non-neoplastic disorder that affects the eye. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Neoplastic Eye Disorder

Professional guidelines

PubMed

Recommendations statement on the immunosuppressive treatment of non-infectious, non-neoplastic, non-anterior uveitis.
Callejas Rubio JL, García Serrano JL, Ortego Centeno N
Med Clin (Barc) 2021 Nov 12;157(9):e316. Epub 2020 Dec 3 doi: 10.1016/j.medcli.2020.10.009. PMID: 33280835
Recommendations statement on the immunosuppressive treatment of non-infectious, non-neoplastic, non-anterior uveitis.
Espinosa G, Herreras JM, Muñoz-Fernández S, García Ruiz de Morales JM, Cordero-Coma M
Med Clin (Barc) 2020 Sep 11;155(5):220.e1-220.e12. Epub 2020 Mar 19 doi: 10.1016/j.medcli.2019.10.023. PMID: 32199631
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893

Recent clinical studies

Etiology

Clinicopathological analysis of eyelid lesions in Sri Lanka.
Nanayakkara DPS, Dissanayake MM, Gunaratne MP, Soysa VK, Mathangasinghe Y
Int Ophthalmol 2023 Jul;43(7):2513-2519. Epub 2023 Mar 7 doi: 10.1007/s10792-023-02651-z. PMID: 36881193
Single-cell analysis reveals new evolutionary complexity in uveal melanoma.
Durante MA, Rodriguez DA, Kurtenbach S, Kuznetsov JN, Sanchez MI, Decatur CL, Snyder H, Feun LG, Livingstone AS, Harbour JW
Nat Commun 2020 Jan 24;11(1):496. doi: 10.1038/s41467-019-14256-1. PMID: 31980621Free PMC Article
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Tumor suppressor genes in ophthalmology.
Harbour JW
Surv Ophthalmol 1999 Nov-Dec;44(3):235-46. doi: 10.1016/s0039-6257(99)00102-2. PMID: 10588442

Diagnosis

Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893
Clinical significance of routine lacrimal sac biopsy during dacryocystorhinostomy: A comprehensive review of literature.
Koturović Z, Knežević M, Rašić DM
Bosn J Basic Med Sci 2017 Feb 21;17(1):1-8. doi: 10.17305/bjbms.2016.1424. PMID: 27754826Free PMC Article
Parotid space: anatomic imaging.
Kanekar SG, Mannion K, Zacharia T, Showalter M
Otolaryngol Clin North Am 2012 Dec;45(6):1253-72. doi: 10.1016/j.otc.2012.08.011. PMID: 23153748
Tumors and pseudotumors of the optic disc.
Shields JA
Acta Ophthalmol Scand 2000 Apr;78(2):156-63. doi: 10.1034/j.1600-0420.2000.078002156.x. PMID: 10794248
Tumor suppressor genes in ophthalmology.
Harbour JW
Surv Ophthalmol 1999 Nov-Dec;44(3):235-46. doi: 10.1016/s0039-6257(99)00102-2. PMID: 10588442

Therapy

Recommendations statement on the immunosuppressive treatment of non-infectious, non-neoplastic, non-anterior uveitis.
Espinosa G, Herreras JM, Muñoz-Fernández S, García Ruiz de Morales JM, Cordero-Coma M
Med Clin (Barc) 2020 Sep 11;155(5):220.e1-220.e12. Epub 2020 Mar 19 doi: 10.1016/j.medcli.2019.10.023. PMID: 32199631
Properties of FDA-approved small molecule protein kinase inhibitors: A 2020 update.
Roskoski R Jr
Pharmacol Res 2020 Feb;152:104609. Epub 2019 Dec 17 doi: 10.1016/j.phrs.2019.104609. PMID: 31862477
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893
Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
Radiation therapy: posterior segment complications.
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:114-23. Epub 2013 Aug 26 doi: 10.1159/000351088. PMID: 23989132

Prognosis

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma.
Zhang J, Ren X, Wang B, Cao J, Tian L, Liu M
Head Face Med 2018 Sep 27;14(1):20. doi: 10.1186/s13005-018-0177-1. PMID: 30261897Free PMC Article
Tumours of the lacrimal gland. Epidemiological, clinical and genetic characteristics.
von Holstein SL
Acta Ophthalmol 2013 Nov;91 Thesis 6:1-28. doi: 10.1111/aos.12271. PMID: 24893972
Pathological features of diseases associated with human T-cell leukemia virus type I.
Ohshima K
Cancer Sci 2007 Jun;98(6):772-8. Epub 2007 Mar 27 doi: 10.1111/j.1349-7006.2007.00456.x. PMID: 17388788
Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features.
Coupland SE, Heimann H, Bechrakis NE
Graefes Arch Clin Exp Ophthalmol 2004 Nov;242(11):901-13. Epub 2004 Oct 29 doi: 10.1007/s00417-004-0973-0. PMID: 15565454
Pathophysiological implications of stroma pattern formation in uveal melanoma.
Clarijs R, Ruiter DJ, De Waal RM
J Cell Physiol 2003 Mar;194(3):267-71. doi: 10.1002/jcp.10214. PMID: 12548547

Clinical prediction guides

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.
Telomeres Mendelian Randomization Collaboration, Haycock PC, Burgess S, Nounu A, Zheng J, Okoli GN, Bowden J, Wade KH, Timpson NJ, Evans DM, Willeit P, Aviv A, Gaunt TR, Hemani G, Mangino M, Ellis HP, Kurian KM, Pooley KA, Eeles RA, Lee JE, Fang S, Chen WV, Law MH, Bowdler LM, Iles MM, Yang Q, Worrall BB, Markus HS, Hung RJ, Amos CI, Spurdle AB, Thompson DJ, O'Mara TA, Wolpin B, Amundadottir L, Stolzenberg-Solomon R, Trichopoulou A, Onland-Moret NC, Lund E, Duell EJ, Canzian F, Severi G, Overvad K, Gunter MJ, Tumino R, Svenson U, van Rij A, Baas AF, Bown MJ, Samani NJ, van t'Hof FNG, Tromp G, Jones GT, Kuivaniemi H, Elmore JR, Johansson M, Mckay J, Scelo G, Carreras-Torres R, Gaborieau V, Brennan P, Bracci PM, Neale RE, Olson SH, Gallinger S, Li D, Petersen GM, Risch HA, Klein AP, Han J, Abnet CC, Freedman ND, Taylor PR, Maris JM, Aben KK, Kiemeney LA, Vermeulen SH, Wiencke JK, Walsh KM, Wrensch M, Rice T, Turnbull C, Litchfield K, Paternoster L, Standl M, Abecasis GR, SanGiovanni JP, Li Y, Mijatovic V, Sapkota Y, Low SK, Zondervan KT, Montgomery GW, Nyholt DR, van Heel DA, Hunt K, Arking DE, Ashar FN, Sotoodehnia N, Woo D, Rosand J, Comeau ME, Brown WM, Silverman EK, Hokanson JE, Cho MH, Hui J, Ferreira MA, Thompson PJ, Morrison AC, Felix JF, Smith NL, Christiano AM, Petukhova L, Betz RC, Fan X, Zhang X, Zhu C, Langefeld CD, Thompson SD, Wang F, Lin X, Schwartz DA, Fingerlin T, Rotter JI, Cotch MF, Jensen RA, Munz M, Dommisch H, Schaefer AS, Han F, Ollila HM, Hillary RP, Albagha O, Ralston SH, Zeng C, Zheng W, Shu XO, Reis A, Uebe S, Hüffmeier U, Kawamura Y, Otowa T, Sasaki T, Hibberd ML, Davila S, Xie G, Siminovitch K, Bei JX, Zeng YX, Försti A, Chen B, Landi S, Franke A, Fischer A, Ellinghaus D, Flores C, Noth I, Ma SF, Foo JN, Liu J, Kim JW, Cox DG, Delattre O, Mirabeau O, Skibola CF, Tang CS, Garcia-Barcelo M, Chang KP, Su WH, Chang YS, Martin NG, Gordon S, Wade TD, Lee C, Kubo M, Cha PC, Nakamura Y, Levy D, Kimura M, Hwang SJ, Hunt S, Spector T, Soranzo N, Manichaikul AW, Barr RG, Kahali B, Speliotes E, Yerges-Armstrong LM, Cheng CY, Jonas JB, Wong TY, Fogh I, Lin K, Powell JF, Rice K, Relton CL, Martin RM, Davey Smith G
JAMA Oncol 2017 May 1;3(5):636-651. doi: 10.1001/jamaoncol.2016.5945. PMID: 28241208Free PMC Article
The role of intrinsic epithelial activation in the pathogenesis of Sjögren's syndrome.
Manoussakis MN, Kapsogeorgou EK
J Autoimmun 2010 Nov;35(3):219-24. Epub 2010 Aug 4 doi: 10.1016/j.jaut.2010.06.011. PMID: 20685080
Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5.
Xu XL, Lee TC, Offor N, Cheng C, Liu A, Fang Y, Jhanwar SC, Abramson DH, Cobrinik D
Am J Pathol 2010 Jul;177(1):424-35. Epub 2010 May 27 doi: 10.2353/ajpath.2010.090512. PMID: 20508032Free PMC Article
Telomerase activity and telomere length in thyroid neoplasia: biological and clinical implications.
Matthews P, Jones CJ, Skinner J, Haughton M, de Micco C, Wynford-Thomas D
J Pathol 2001 Jun;194(2):183-93. doi: 10.1002/path.848. PMID: 11400147
Immunoreactivity of neoplastic and non-neoplastic monocytoid B lymphocytes for DBA.44 and other antibodies.
Ohsawa M, Kanno H, Machii T, Aozasa K
J Clin Pathol 1994 Oct;47(10):928-32. doi: 10.1136/jcp.47.10.928. PMID: 7962607Free PMC Article

Recent systematic reviews

Diagnostic Utility of Diffusion-Weighted Imaging and Apparent Diffusion Coefficient for Common Orbital Lesions: A Review.
Cameron CA, Tong JY, Juniat V, Patel S, Selva D
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):515-521. doi: 10.1097/IOP.0000000000002092. PMID: 34798654
Recommendations statement on the immunosuppressive treatment of non-infectious, non-neoplastic, non-anterior uveitis.
Espinosa G, Herreras JM, Muñoz-Fernández S, García Ruiz de Morales JM, Cordero-Coma M
Med Clin (Barc) 2020 Sep 11;155(5):220.e1-220.e12. Epub 2020 Mar 19 doi: 10.1016/j.medcli.2019.10.023. PMID: 32199631
Treatment recommendations for non-infectious anterior uveitis.
Espinosa G, Muñoz-Fernández S, García Ruiz de Morales JM, Herreras JM, Cordero-Coma M
Med Clin (Barc) 2017 Dec 20;149(12):552.e1-552.e12. Epub 2017 Sep 11 doi: 10.1016/j.medcli.2017.06.059. PMID: 28911893

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...