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Neuroendocrine carcinoma

MedGen UID:
104919
Concept ID:
C0206695
Neoplastic Process
Synonyms: Carcinoma, Neuroendocrine; Carcinomas, Neuroendocrine; Neuroendocrine Carcinoma; Neuroendocrine Carcinomas
SNOMED CT: Neuroendocrine carcinoma (253000007); Neuroendocrine carcinoma (55937004)
 
Monarch Initiative: MONDO:0002120

Definition

A usually aggressive carcinoma composed of malignant cells exhibiting neuroendocrine differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine carcinoma

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Hernandez LE, Mohsin N, Yaghi M, Frech FS, Dreyfuss I, Nouri K
Dermatol Ther 2022 Mar;35(3):e15292. Epub 2022 Jan 5 doi: 10.1111/dth.15292. PMID: 34967084
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Lu J, Li Y, Wang J
Front Cell Infect Microbiol 2022;12:916506. Epub 2022 Jul 13 doi: 10.3389/fcimb.2022.916506. PMID: 35909972Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Oronsky B, Ma PC, Morgensztern D, Carter CA
Neoplasia 2017 Dec;19(12):991-1002. Epub 2017 Nov 5 doi: 10.1016/j.neo.2017.09.002. PMID: 29091800Free PMC Article

Diagnosis

Clement D, Brown S, Leerdam MV, Tesselaar M, Ramage J, Srirajaskanthan R
Curr Oncol Rep 2024 Feb;26(2):121-128. Epub 2024 Jan 25 doi: 10.1007/s11912-024-01494-w. PMID: 38270848
Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Li M, Yang L, Lu H
Pathol Oncol Res 2022;28:1610747. Epub 2022 Nov 23 doi: 10.3389/pore.2022.1610747. PMID: 36507119Free PMC Article
Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Borczuk AC
Surg Pathol Clin 2020 Mar;13(1):35-55. Epub 2019 Nov 29 doi: 10.1016/j.path.2019.10.002. PMID: 32005434

Therapy

Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Morizane C, Machida N, Honma Y, Okusaka T, Boku N, Kato K, Nomura S, Hiraoka N, Sekine S, Taniguchi H, Okano N, Yamaguchi K, Sato T, Ikeda M, Mizuno N, Ozaka M, Kataoka T, Ueno M, Kitagawa Y, Terashima M, Furuse J; Japan Clinical Oncology Group (JCOG)
JAMA Oncol 2022 Oct 1;8(10):1447-1455. doi: 10.1001/jamaoncol.2022.3395. PMID: 35980649Free PMC Article
Wermke M, Felip E, Gambardella V, Kuboki Y, Morgensztern D, Hamed ZO, Liu M, Studeny M, Owonikoko TK
Future Oncol 2022 Aug;18(24):2639-2649. Epub 2022 Jul 11 doi: 10.2217/fon-2022-0196. PMID: 35815644
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article

Prognosis

Fang JM, Li J, Shi J
World J Gastroenterol 2022 Mar 14;28(10):1009-1023. doi: 10.3748/wjg.v28.i10.1009. PMID: 35431496Free PMC Article
Das S, Dasari A
Curr Oncol Rep 2021 Mar 14;23(4):43. doi: 10.1007/s11912-021-01029-7. PMID: 33719003Free PMC Article
Walsh NM, Cerroni L
J Cutan Pathol 2021 Mar;48(3):411-421. Epub 2020 Dec 3 doi: 10.1111/cup.13910. PMID: 33128463
Abdelmeguid AS, Bell D, Hanna EY
Curr Oncol Rep 2019 Feb 26;21(3):26. doi: 10.1007/s11912-019-0776-4. PMID: 30806835
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article

Clinical prediction guides

Sorbye H, Grande E, Pavel M, Tesselaar M, Fazio N, Reed NS, Knigge U, Christ E, Ambrosini V, Couvelard A, Tiensuu Janson E
J Neuroendocrinol 2023 Mar;35(3):e13249. Epub 2023 Mar 16 doi: 10.1111/jne.13249. PMID: 36924180
Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Xu B, Fuchs TL, Ahmadi S, Alghamdi M, Alzumaili B, Bani MA, Baudin E, Chou A, De Leo A, Fagin JA, Ganly I, Glover A, Hartl D, Kanaan C, Khneisser P, Najdawi F, Nigam A, Papachristos A, Repaci A, Spanheimer PM, Solaroli E, Untch BR, Barletta JA, Tallini G, Al Ghuzlan A, Gill AJ, Ghossein RA
J Clin Oncol 2022 Jan 1;40(1):96-104. Epub 2021 Nov 3 doi: 10.1200/JCO.21.01329. PMID: 34731032Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Sorbye H, Welin S, Langer SW, Vestermark LW, Holt N, Osterlund P, Dueland S, Hofsli E, Guren MG, Ohrling K, Birkemeyer E, Thiis-Evensen E, Biagini M, Gronbaek H, Soveri LM, Olsen IH, Federspiel B, Assmus J, Janson ET, Knigge U
Ann Oncol 2013 Jan;24(1):152-60. Epub 2012 Sep 11 doi: 10.1093/annonc/mds276. PMID: 22967994

Recent systematic reviews

Froehlich MH, Shih MC, Shehee L, Kompelli AR, Aylward A, Nguyen SA, Kaczmar JM, Nathan CA, Day T, Neskey DM
Head Neck 2022 Jul;44(7):1725-1736. Epub 2022 Apr 18 doi: 10.1002/hed.27055. PMID: 35437851
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Singh S, Bergsland EK, Card CM, Hope TA, Kunz PL, Laidley DT, Lawrence B, Leyden S, Metz DC, Michael M, Modahl LE, Myrehaug S, Padda SK, Pommier RF, Ramirez RA, Soulen M, Strosberg J, Sung A, Thawer A, Wei B, Xu B, Segelov E
J Thorac Oncol 2020 Oct;15(10):1577-1598. Epub 2020 Jul 11 doi: 10.1016/j.jtho.2020.06.021. PMID: 32663527
Tempfer CB, Tischoff I, Dogan A, Hilal Z, Schultheis B, Kern P, Rezniczek GA
BMC Cancer 2018 May 4;18(1):530. doi: 10.1186/s12885-018-4447-x. PMID: 29728073Free PMC Article
Rivero A, Liang J
Int Forum Allergy Rhinol 2016 Jul;6(7):744-51. Epub 2016 Feb 16 doi: 10.1002/alr.21734. PMID: 26880574

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    Clinical resources

    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

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